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Bio58 Final > Questions 1 thru 6 p2 > Flashcards

Questions 1 thru 6 p2 Flashcards

1
Q

What disease state does hyperlipidemia cause?

A

CAD - Coronary Artery Disease (atherosclerosis)

leading to stroke and myocardial infarction

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2
Q

What is another name for hyperlipidemia?

A

High Cholesterol (high fat in blood)

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3
Q

What are lipoproteins?

A

Proteins with some fat that circulate in blood to transport fats, hormones and other substances

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4
Q

Where are lipoproteins synthesized?

A
  1. Intestinal Mucosa

2. Liver

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5
Q

Name the Lipoproteins

A
  1. Chylomicron “the biggest”
  2. HDL - High Density Lipoprotein
  3. IDL - Intermediate Density Lipoprotein
  4. LDL - Low Density Lipoprotein
  5. VLDL - Very Low Density Lipoprotein
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6
Q

List lipoproteins from High to Low for TG levles

A
  1. Chylomicron
  2. VLDL
  3. LDL
  4. HDL
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7
Q

List lipoproteins from High to Low for Protein levels

A
  1. HDL
  2. LDL
  3. VLDL
  4. Chylomicron
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8
Q

List lipoproteins from High to Low for Cholesterol levels

A
  1. LDL
  2. HDL
  3. VLDL
  4. Chylomicron
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9
Q

Name 4 cholesterol lowering drugs

A
  1. Gemfibrozil
  2. Niacin
  3. Cholestryamine
  4. Statin Drugs
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10
Q

What is the MOA of Gemfibrozil?

A
  1. inhibits synthesis of VLDL

2. increase activity of lipoprotein lipase activity

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11
Q

What is lipoprotein lipase?

A

An enzyme that INHIBITS synthesis of cholesterol in liver

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12
Q

What is the MOA of the drug Niacin?

A

NOT a drug - Vitamin B3

  1. inhibits lipolysis in adipose tissue
  2. decreases synthesis of TG - needed for synthesis of VLDL
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13
Q

What’s notable about Niacin and what can you do about it?

A

Can cause flushing and itching

take ASA to reduce inflammation

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14
Q

What is another name for Cholestryamine?

A

Bile Sequestrants

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15
Q

What is the MOA of Cholestryamine/bile sequestrants?

A

DECREASE LDL by:

  1. decreasing bile acid (drug = resin that attaches to (-) bile acids and excretes them in feces
  2. liver then converts cholesterol to bile acid
  3. which depletes cholesterol store in liver
  4. so liver takes LDL from blood to make more cholesterol for storage
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16
Q

What is another name for Statin Drugs?

A

HMG-CoA Reductase Inhibitors

17
Q

List as many statin drugs as we need to know.

A
  1. Simvastatin/Zocor
  2. Atorvastatin/Lipitor
  3. Lovastatin/Mevacor
  4. Rosuvastatin/Crestor
  5. Pravastatin/Pravachol
18
Q

What is the MOA of Statin or HMG-CoA Reductase Inhibitors?

A
  1. inhibit HMG-CoA Reductase in the liver which is necessary for buildilng LDL
19
Q

What is a dangerous SE of Statin drugs?

A

decrease in liver function

20
Q

What is the target when using cholesterol lowering drugs?

A

Reduce the amount of free lipoproteins in the blood to reduce the chance of atherosclerosis, hence stroke and heart attack

Bio58 Final (9 decks)

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