quantitate study design - critial numbers 1 Flashcards

1
Q

what do descriptive statistics do

A

describe a sample

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2
Q

what do inferential statistics do

A

make inferences about our population

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3
Q

how can a sample be biased

A

when certain subgroups from the target population are over/under represented

it arises when imperfections in the research process cause our findings to deviate from the truth

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4
Q

what makes results generalisable

A

when the sample represents the population of interest

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5
Q

what does bias impact

A

the validity and reliability of study findings

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6
Q

what are the 5 types of bias

A

sampling bias
recall bias
information bias
the ‘hawthorne’ effect
attrition bias

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7
Q

define sampling bias

A

when the sample does not represent the population of interest

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8
Q

define recall bias

A

when there is inaccurate recall of past events/exposures/behaviours

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9
Q

define information bias

A

when there is incorrect measurement eg miscalibrated machine

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10
Q

define the ‘hawthorne’ effect

A

when participants change their behaviour when they know they are being observed

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11
Q

define attrition bias

A

when there is differential dropout from studies eg sicker participants drop out so our outcome is only measured on healthier participants

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12
Q

what are confounding variables

A

they obscure the real-life effect of exposure on an outcome

a confounder is related to both exposure and outcome

but is not on the causal pathway

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13
Q

what are the 2 types of study designs

A

experimental
observational

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14
Q

what is an experimental study design

A

when the researchers have intervened in some way

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15
Q

what is an observational study design

A

when the researchers have not intervened, and have merely observed

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16
Q

what are the 3 types of observational studies

A

retrospective - looking back into the past

cross-sectional - a single snapshot in time

prospective - following up over time

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17
Q

what are randomised controlled trials

A

when participants are randomly allocated to different interventions and follow up

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18
Q

what are 4 variations on the standard randomised controlled trial design

A

cluster randomised trials
crossover trials
multi arm and factorial trials
adaptive design trials

19
Q

what are cluster randomised trials

A

when participant sare randomised in grooups rather than indivusally

20
Q

what are crossover trials

A

when participants receive both interventions in a randomised order

21
Q

what are multi arm and factorial trials

A

when two or more interventions are evaluated in a single study

22
Q

what are adaptive design trials

A

when accruing information is used to inform planned design adaptations

23
Q

what are 4 variations on the standard randomised controlled trial design

A

cluster randomised trials
crossover trials
multi arm and factorial trials
adaptive design trials

24
Q

give 4 pros of randomised control trials

A
  • gold standard
  • reduces potential for confounding
  • reduces bias via control and blinding
  • can determine causal effects
25
Q

give 3 cons of randomised control trials

A
  • can be unfeasible or unethical
  • require expert management
  • expensive
26
Q

what are cohort studies

A

non randomised
observational
typically prospective

27
Q

give 3 pros of cohort studies

A
  • useful when random allocation not possible
  • can work for rare exposures - select participants on the basis of exposure
  • can examine multiple outcomes
28
Q

give 3 cons of cohort studies

A
  • may require long follow up
  • can be expensive
  • not ideal for rare outcomes
29
Q

what are case control studies

A

non randomised
observationall
retrospective

30
Q

give 3 pros of case control studies

A
  • faster because use past data so don’t need long follow up
  • useful for rare outcomes - select participants on the basis of outcome
  • cheaper
31
Q

give 3 cons of case control studies

A
  • more prone to bias or poor quality data
  • harder to show causal relationship
  • not ideal for rare exposures
32
Q

what are cross-sectional studies

A

non randomised
observational
single time point

33
Q

how do cross-sectional studies work

A

1 sample, 4 outcomes –>

unexposed, outcome
unexposed, no outcome
exposed, outcome,
exposed, no outcome

34
Q

give 3 pros of cross sectional studies

A
  • relatively quick
  • cheap
  • can assess multiple exposures/outcomes
35
Q

give 3 cons of cross sectional studies

A
  • susceptible to bias
  • cannot prove causality
  • not ideal for rare exposures/outcomes
36
Q

what are ecologolical studies

A

when the unit of observation is a group rather than an individual

37
Q

give 2 pros of ecological studies

A
  • large scale comparisons
  • can quantify geographical or temporal trends
38
Q

give 2 cons of ecological studies

A
  • ecological fallacy
  • cannot make inferences at the individual level
39
Q

what is the hierarchy of evidence from best to worst

A

1) systematic review/meta-analysis
2) randomised control trials
3) cohort studies
3) case control studies
4) cross sectional studies
5) case studies/ expert opinion/ anecdote

40
Q

how do cross-sectional studies work

A

1 sample
4 outcomes –>

41
Q

how do case control studies work

A

1 sample –> divides into cases and controls

cases –> exposure
controls –> exposure

42
Q

how do cohort studies work

A

1 sample –> divides into exposed and unexposed

exposed –> outcome
unexposed –> outcome

43
Q

how do randomised controlled trials work

A

1 sample –> divided into intervetion an comparator

intervention –> outcome
comparator –> outcome