QUALITY CONTROL IN HISTOLOGY LABOLATORY

Question 1

Why is quality control important in cytology labolatory

Answer 1

1. Avoiding false positive and false negative results.
2. Avoiding untimely results

Question 2

where does false negative pap interpretations result from

Answer 2

1. Sampling error
   2 Laboratory error

Question 3

Explain sampling error

Answer 3

The collection device may fail to sample lesional cells.
Lesional cells are the specific cells of interest for examination.
Even if lesional cells are collected, there might be inefficient transfer of these cells from the collection device to the glass slide.

Question 4

explain laboratory error

Answer 4

1. screening (i.e., abnormal cells are missed)
2. interpretation (i.e., abnormal cells are misinterpreted as benign)

Question 5

how is quality check achieved

Answer 5

1. By performing a prospective 10% rescreen of negative Paps
2. . By performing retrospective rescreen (5-year look back)
3. Cytologic-Histologic correlation

Question 6

what is the purpose of doing aprospective 10% rescreen of negative Paps

Answer 6

Aims at identifying unreliable cytotechnologist

Question 7

relavance of performing retrospective rescreen (5-year look back) in cytology QA

Answer 7

Targets archived negative Paps from women with a new Pap interpretation of HSIL or cancer