HORMONAL CYTOLOGY Flashcards

Hormonal cytology

1
Q

what is hormonal cytology

A

Is the study of cells that will give us the hormonal status of female

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2
Q

what are the 2 hormones common in a female

A
  1. progestrone
  2. Eostrogen
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3
Q

in a young female when is progestrone high

A

through out the pregnancy

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4
Q

what is the relationship between pregestrone and eostrogen

A

when progestron is high eostrogen is low and vice versa

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5
Q

how is cytology used to determine which hormone is high

A

by looking at the parten of squamous cells, the appearance of squamous cells tells us which homorne is high

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6
Q

why are the levels of homornes determined by the appearance of squamous cells

A

because the homornes regulate the maturity of squamous statified cells

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7
Q

which layers of squamous cells are much used in homornal cytology

A

parabasal, intermediate and superficial

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8
Q

which cells are not supposed to be seen in pap smear and their clinical significance if present

A

basal cells
when found it shows there is an errosion (something is wrong)

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9
Q

what does A:B:C mean in hormonal cytology/maturation index

A

A: represents parabasal cells
B: represents intermediate cells
C: represents superficial cells

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10
Q

How do we asses maturation index

A

By counting the whole numbers of total cells, then the numbers are alligned against the fomart A:B:C but in total should be 100

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11
Q

explain a shift to right

A

it means the cell dominating are superficial cells, which means eostrogen is high. superficial is increased more than the other cells

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12
Q

explain shift to the middle

A

it means the cells dominating is intermidiate, it signifies progestrone is high

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13
Q

explain a shift to the left

A

it signifies that parabasal cells are high. eostrogen and progestrone are high

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14
Q

when does shift to the left occur

A

during baby delivery the progestrone drops to match with eostrogen as a result there is a shift to the left

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15
Q

normal occurence of shift to the left

A

during childhood and postmenstrual menopause there will be a shift to the left

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16
Q

what are the pitfalls/problems of maturation index

A
  1. Cytolysis :When 50% or more cells are degenerated with stripped nuclei, no evaluation should be done
  2. Lack of information
  3. Inflammation
    Produces hypermaturation,masks squamous cells
  4. Eroded vaginal mucosa will falsely increase the number of basal cells
  5. Faulty fixation and staining defects
17
Q

Normal cytohormonal average in new borns

A

0-90-10 +/-10

18
Q

Normal cytohormonal average in menstral age

A

0-60-40 +/-20

19
Q

Normal cytohormonal average in pre-ovulation

A

0-40-60

20
Q

Normal cytohormonal average in ovulation and post ovulation

A

0-70-30 +/-15

21
Q

Normal cytohormonal average in menstral flow

A

0-60-40 +/-20

22
Q

Normal cytohormonal average in menopause

A

0-70-30 +/-20

23
Q

Normal cytohormonal average in late menopause

A

parabasal cells tend to increase due to decreased eostrogen levels