Q wk 3

Question 1

Pathological condition in which the proximal tubules in the kidneys do not reabsorb glucose, amino acids, uric acids, and bicarbonates resulting in their loss to the urine concentrate.

Lesch-Nyhan Syndrome
Gout
Congestive heart failure
Fanconi Syndrome

Answer 1

Fanconi Syndrome

Question 2

Given the following information, calculate the creatinine clearance:

Urine creatinine: 87 mg/dL

Plasma creatinine: 3.2 mg/dL

Urine volume for 24 hours: 810 mL

Patient BSA: 1.92

13.70
11.05
14.25
10.53

Answer 2

13.70

Question 3

Given the following results, determine if the patient is experiencing azotemia and what kind.

BUN: 56 mg/dL

Creatinine: 2.1 mg/dL

Normal kidney function
Pre-renal azotemia
Renal azotemia
Post-renal azotemia

Answer 3

Pre-renal azotemia

Question 4

Which of the following serves as the glomerular filtration rate for clinicians?

Urea
Creatinine
Uric acid
Ammonia

Answer 4

Creatinine

Question 5

What does an increase in serum enzyme levels indicate?

Decreased enzyme catabolism
Accelerated enzyme production
Tissue damage and necrosis
Increased glomerular filtration rate

Answer 5

Tissue damage and necrosis

Question 6

When measuring enzyme activity, if the instrument is operating at 5 C lower than the temperature prescribed for the method, how would the results be affected?

Lower than expected
Higher than expected
Varied, showing no pattern in results
all would be clinically abnormal

Answer 6

Lower than expected

Question 7

The following statement could be used to describe zero-order kinetics:

Substrate is present in excess, rate of reaction is constant with time and dependent only on the concentration of enzyme in the system.

True
False

Answer 7

True

Question 8

These type of inhibitors may allow substrate binding but will inhibit the formation of product.

Competitive inhibitors
Non-competitive inhibitors
Uncompetitive inhibitors
All inhibitors do this

Answer 8

Non-competitive inhibitors