exam 3 review Qs Flashcards

1
Q

The major transporter of drugs

A

Albumin

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2
Q

The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system

A

First Pass Effect

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3
Q

The study of the biochemical and physiological effects of drugs and their mechanisms of actions:

A

Pharmacodynamics

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4
Q

This tumor marker often is measured in both the total and free form

A

PSA

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5
Q

The concentration range of a drug within which the drug produces the desired effect

A

Therapeutic Range

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6
Q

This tumor marker is primarily used as a marker for ovarian cancer:

A

CA-125

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7
Q

This is found as a contaminant of homemade liquors and can cause optic neuropathy:

A

Methanol

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8
Q

This is a significant environmental pollutant and is easily taken up by crops – especially tobacco:

A

Cadmium

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9
Q

This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test:

A

Digoxin

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10
Q

The most direct and effective route of administration of a drug:

A

IV

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11
Q

This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine:

A

Neuroblastoma

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12
Q

This test is used along with hCG to classify nonseminomatous tumor

A

AFP

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13
Q

This is a kind of testing method that can be performed on solid tissue tumor markers:

A

Immunohistochemistry

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14
Q

The predicted dose that would produce a toxic response in 50% of the population:

A

TD50

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15
Q

This may occur when analyte concentrations exceed the analytical range excessively

A

Hook Effect

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16
Q

This drug is the hepatic metabolite of procainamide

A

NAPA

17
Q

The study of the movement of drugs in the body:

A

Pharmacokinetics

18
Q

This drug commonly is tested for both the total and free forms:

A

Phenytoin (Dilantin)

19
Q

Endogenous substances biologically synthesized either in living cells or in microorganisms:

A

Toxins

20
Q

This method of analysis of toxic agent has good sensitivity but lacks specificity:

A

Screening

21
Q

These types of tumor markers are valuable in diagnosing neuroblastomas, pituitary and adrenal adenomas:

A

Endocrine Tumor Markers

22
Q

This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer:

A

CEA

23
Q

Uses the results from animal experiments to predict what level of exposure will cause harm to humans:

A

Descriptive Toxicology

24
Q

This is a metal with 3 forms, one of which is liquid at room temp:

A

Mercury

25
Q

This is a useful system to compare relative toxicities of substances as the predicted endpoint is death:

A

Dose-Response Relationship

26
Q

B-macroglobulin and immunoglobulins are part of this group of tumor markers

A

Serum Protein Tumor Markers

27
Q

Chemicals and drugs that are not normally found in or produced by the body:

A

Xenobiotics

28
Q

“Trace Element Free”

A

Royal Blue Top Tube

29
Q

This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody:

A

HAMAs

30
Q

This drug is ototoxic enough that it is recommended that baseline audiology testing is performed:

A

Tobramycin

31
Q

This type of tumor marker can help to choose between endocrine and cytotoxic therapies:

A

Receptor Tumor Marker