exam 3 review Qs Flashcards
The major transporter of drugs
Albumin
The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system
First Pass Effect
The study of the biochemical and physiological effects of drugs and their mechanisms of actions:
Pharmacodynamics
This tumor marker often is measured in both the total and free form
PSA
The concentration range of a drug within which the drug produces the desired effect
Therapeutic Range
This tumor marker is primarily used as a marker for ovarian cancer:
CA-125
This is found as a contaminant of homemade liquors and can cause optic neuropathy:
Methanol
This is a significant environmental pollutant and is easily taken up by crops – especially tobacco:
Cadmium
This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test:
Digoxin
The most direct and effective route of administration of a drug:
IV
This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine:
Neuroblastoma
This test is used along with hCG to classify nonseminomatous tumor
AFP
This is a kind of testing method that can be performed on solid tissue tumor markers:
Immunohistochemistry
The predicted dose that would produce a toxic response in 50% of the population:
TD50
This may occur when analyte concentrations exceed the analytical range excessively
Hook Effect
This drug is the hepatic metabolite of procainamide
NAPA
The study of the movement of drugs in the body:
Pharmacokinetics
This drug commonly is tested for both the total and free forms:
Phenytoin (Dilantin)
Endogenous substances biologically synthesized either in living cells or in microorganisms:
Toxins
This method of analysis of toxic agent has good sensitivity but lacks specificity:
Screening
These types of tumor markers are valuable in diagnosing neuroblastomas, pituitary and adrenal adenomas:
Endocrine Tumor Markers
This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer:
CEA
Uses the results from animal experiments to predict what level of exposure will cause harm to humans:
Descriptive Toxicology
This is a metal with 3 forms, one of which is liquid at room temp:
Mercury
This is a useful system to compare relative toxicities of substances as the predicted endpoint is death:
Dose-Response Relationship
B-macroglobulin and immunoglobulins are part of this group of tumor markers
Serum Protein Tumor Markers
Chemicals and drugs that are not normally found in or produced by the body:
Xenobiotics
“Trace Element Free”
Royal Blue Top Tube
This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody:
HAMAs
This drug is ototoxic enough that it is recommended that baseline audiology testing is performed:
Tobramycin
This type of tumor marker can help to choose between endocrine and cytotoxic therapies:
Receptor Tumor Marker
