exam 3 wk Qs Flashcards

1
Q

Which of the following statements is not true concerning testing for drugs of abuse?

A two-tired testing approach includes screening and confirmatory testing
Confirmatory testing must use methods with high specificity and low sensitivity
Screening tests detect classes of drugs
GC-MS is the reference method used for confirmation

A

Confirmatory testing must use methods with high specificity and low sensitivity

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2
Q

Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.

True
False

A

True

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3
Q

Which of the following is not true concerning analysis of toxic agents?

Screening tests have good specificity but lack sensitivity
Confirmatory tests report the concentration of the analyte
Screening tests are a rapid test intended to detect the presence of a substance
The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS_

A

Screening tests have good specificity but lack sensitivity

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4
Q

Toxic levels of acetaminophen are associated with

Ototoxicity
Nephrotoxicity
Hepatotoxicity
Neurotoxicity

A

Hepatotoxicity

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5
Q

Pharmacokinetics and drug concentration are influenced by which of the following factors?

Absorption, distribution, excretion, metabolism
Absorption, bioavailability, excretion, metabolism
Biotransformation, distribution, excretion, metabolism
Adaption, distribution, excretion, metabolism

A

Absorption, distribution, excretion, metabolism

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6
Q

A drug’s most direct and effective method of delivery to its site of action is:

Oral administration
Intramuscular injection
Intravenous administration
Aerosol ingestion

A

Intravenous administration

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7
Q

A blood draw to determine a peak level of a drug should be drawn:

One hour after an orally administered dose
Immediately after drug administration
90 minutes after an orally administered dose
Immediately before drug administration

A

One hour after an orally administered dose

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8
Q

Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.

True
False

A

True

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9
Q

Tumor marker methodology include all of the following except:

Immunoassays
Gas chromatography
Immunohistochemistry
Enzyme analysis

A

Gas chromatography

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10
Q

Which of the following tumor markers is classified as an oncofetal antigen?

Carcinoembryonic antigen (CEA)
CA 19-9
BRCA-1
hCG

A

Carcinoembryonic antigen (CEA)

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11
Q

Which tumor marker is associated with neuroblastoma?

CA-15-3
Carcinoembryonic antigen (CEA)
CA 125
Homovanillic acid (HVA)

A

Homovanillic acid (HVA)

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12
Q

Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results

True
False

A

False

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