exam 3 wk Qs

Question 1

Which of the following statements is not true concerning testing for drugs of abuse?

A two-tired testing approach includes screening and confirmatory testing
Confirmatory testing must use methods with high specificity and low sensitivity
Screening tests detect classes of drugs
GC-MS is the reference method used for confirmation

Answer 1

Confirmatory testing must use methods with high specificity and low sensitivity

Question 2

Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.

True
False

Answer 2

True

Question 3

Which of the following is not true concerning analysis of toxic agents?

Screening tests have good specificity but lack sensitivity
Confirmatory tests report the concentration of the analyte
Screening tests are a rapid test intended to detect the presence of a substance
The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS_

Answer 3

Screening tests have good specificity but lack sensitivity

Question 4

Toxic levels of acetaminophen are associated with

Ototoxicity
Nephrotoxicity
Hepatotoxicity
Neurotoxicity

Answer 4

Hepatotoxicity

Question 5

Pharmacokinetics and drug concentration are influenced by which of the following factors?

Absorption, distribution, excretion, metabolism
Absorption, bioavailability, excretion, metabolism
Biotransformation, distribution, excretion, metabolism
Adaption, distribution, excretion, metabolism

Answer 5

Absorption, distribution, excretion, metabolism

Question 6

A drug’s most direct and effective method of delivery to its site of action is:

Oral administration
Intramuscular injection
Intravenous administration
Aerosol ingestion

Answer 6

Intravenous administration

Question 7

A blood draw to determine a peak level of a drug should be drawn:

One hour after an orally administered dose
Immediately after drug administration
90 minutes after an orally administered dose
Immediately before drug administration

Answer 7

One hour after an orally administered dose

Question 8

Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.

True
False

Answer 8

True

Question 9

Tumor marker methodology include all of the following except:

Immunoassays
Gas chromatography
Immunohistochemistry
Enzyme analysis

Answer 9

Gas chromatography

Question 10

Which of the following tumor markers is classified as an oncofetal antigen?

Carcinoembryonic antigen (CEA)
CA 19-9
BRCA-1
hCG

Answer 10

Carcinoembryonic antigen (CEA)

Question 11

Which tumor marker is associated with neuroblastoma?

CA-15-3
Carcinoembryonic antigen (CEA)
CA 125
Homovanillic acid (HVA)

Answer 11

Homovanillic acid (HVA)

Question 12

Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results

True
False

Answer 12

False