q&a smooth muscles Flashcards

1
Q

The action potential of skeletal muscle

A

spreads inward to all parts of the muscle via the T tubules.

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2
Q

The functions of tropomyosin in skeletal muscle include

A

acting as a “relaxing protein” at rest by covering up the sites where myosin
binds to actin.

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3
Q

The cross-bridges of the sarcomere in skeletal muscle are made up of

A

myosin

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4
Q

The contractile response in skeletal muscle

A

produces more tension when the muscle contracts isometrically than when
the muscle contracts isotonically

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5
Q

Gap junctions

A

are present and provide the pathway for rapid spread of excitation from one cardiac muscle fiber to another

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6
Q

Which of the following characteristics is
shared by simple and facilitated diffusion of
glucose?

A

Occurs down an electrochemical gradient

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7
Q

During the upstroke of the nerve action
potential

A

there is net inward current and the cell
interior becomes less negative

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8
Q

Solutions A and B are separated by a
semipermeable membrane that is perme
able to K+, but not to Cl–. Solution A is
100 mM KCl, and solution B is 1 mM KCl.
Which of the following statements about
solution A and solution B is true?

A

K+ will diffuse from solution A to solu
tion B until a membrane potential
develops with solution A negative with
respect to solution B

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9
Q

The correct temporal sequence for events
at the neuromuscular junction is

A

uptake of Ca2+ into the presynaptic terminal; release of acetylcholine (ACh);
depolarization of the muscle end plate

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10
Q

Which characteristic or component is
shared by skeletal muscle and smooth muscle?

A

Elevation of intracellular [Ca2+] for
excitation–contraction coupling

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11
Q

Repeated stimulation of a skeletal muscle
fiber causes a sustained contraction (tetanus).
Accumulation of which solute in intracellular
fluid is responsible for the tetanus?

A

Ca2+

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12
Q

Solutions A and B are separated by a mem
brane that is permeable to Ca2+ and imper
meable to Cl–. Solution A contains 10 mM
CaCl2, and solution B contains 1 mM CaCl2.
Assuming that 2.3 RT/F = 60 mV, Ca2+ will be
at electrochemical equilibrium when

A

solution A is –30 mV

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13
Q

A 42-year-old man with myasthenia gravis
notes increased muscle strength when he is
treated with an acetylcholinesterase (AChE)
inhibitor. The basis for his improvement is
increased

A

levels of ACh at the muscle end plates

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14
Q

In a hospital error, a 60-year-old woman
is infused with large volumes of a solution
that causes lysis of her red blood cells
(RBCs). The solution was most likely

A

300 mM urea

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15
Q

During a nerve action potential, a stimulus is delivered as indicated by the arrow
shown in the following figure. In response
to the stimulus, a second action potential

A

will not occur

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16
Q

Solutions A and B are separated by a
membrane that is permeable to urea.
Solution A is 10 mM urea, and solution B is
5mM urea. If the concentration of urea in
solution A is doubled, the flux of urea across
the membrane will

A

triple

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17
Q

A muscle cell has an intracellular [Na+] of
14 mM and an extracellular [Na+ ] of 140 mM.
Assuming that 2.3 RT/F = 60 mV, what would
the membrane potential be if the muscle cell
membrane were permeable only to Na+?

A

+60 mV

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18
Q

At which labeled point on the action
potential is the K+ closest to electrochemical
equilibrium?

A

5

19
Q

What process is responsible for the
change in membrane potential that occurs
between point 1 and point 3?

A

Movement of Na+ into the cell

20
Q

What process is responsible for the
change in membrane potential that occurs
between point 3 and point 4?

A

Movement of K+ out of the cell

21
Q

The velocity of conduction of action
potentials along a nerve will be increased by

A

myelinating the nerve

22
Q

Solutions A and B are separated by a semi
permeable membrane. Solution A contains
1mMsucrose and 1 mM urea. Solution B con
tains 1 mM sucrose. The reflection coefficient
for sucrose is one and the reflection coefficient
for urea is zero. Which of the following statements about these solutions is correct?

A

Solution A is hyperosmotic with
respect to solution B, and the solutions
are isotonic

23
Q

Transport of D- and L-glucose proceeds at
the same rate down an electrochemical gradient by which of the following processes?

A

Simple diffusion

24
Q

Which of the following will double
the permeability of a solute in a lipid bilayer?

A

Doubling the oil/water partition coefficient of the solute

25
Q

A newly developed local anesthetic
blocks Na+ channels in nerves. Which of the
following effects on the action potential
would it be expected to produce?

A

Decrease the rate of rise of the upstroke
of the action potential

26
Q

At the muscle end plate, acetylcholine
(ACh) causes the opening of

A

Na+ and K+ channels and depolarization
to a value halfway between the Na+ and
K+ equilibrium potentials

27
Q

An inhibitory postsynaptic potential

A

hyperpolarizes the postsynaptic membrane by opening Ca2+ channels

28
Q

Which of the following would occur as a
result of the inhibition of Na+,K+-ATPase?

A

Increased intracellular K+ concentration

29
Q

Which of the following temporal
sequences is correct for excitation
contraction coupling in skeletal muscle?

A

Action potential in the muscle mem
brane; depolarization of the T tubules;
release of Ca2+ from the sarcoplasmic
reticulum (SR)

30
Q

Which of the following transport process
es is involved if transport of glucose from the
intestinal lumen into a small intestinal cell is
inhibited by abolishing the usual Na+ gradient
across the cell membrane?

A

Cotransport

31
Q

In skeletal muscle, which of the following
events occurs before depolarization of the
T tubules in the mechanism of excitation
contraction coupling?

A

Depolarization of the sarcolemmal
membrane

32
Q

Which of the following is an inhibitory
neurotransmitter in the central nervous system (CNS)?

A

γ-Aminobutyric acid (GABA)

33
Q

Adenosine triphosphate (ATP) is used indirectly for which of the following processes?

A

Absorption of glucose by intestinal
epithelial cells

34
Q

Which of the following causes rigor in
skeletal muscle?

A

An increase in adenosine triphosphate
(ATP) level

35
Q

Degeneration of dopaminergic neurons
has been implicated in

A

Parkinson’s disease

36
Q

Assuming complete dissociation of all
solutes, which of the following solutions
would be hyperosmotic to 1 mM NaCl?

A

1 mM CaCl2

37
Q

A new drug is developed that blocks the
transporter for H+ secretion in gastric parie
tal cells. Which of the following transport
processes is being inhibited?

A

Primary active transport

38
Q

A 56-year-old woman with severe mus
cle weakness is hospitalized. The only
abnormality in her laboratory values is an
elevated serum K+ concentration. The elevated serum K+ causes muscle weakness
because

A

Na+ channels are closed by depolarization

39
Q

Which of the following hormones causes
contraction of vascular smooth muscle?

A

Antidiuretic hormone (ADH)

40
Q

Which of the following hormones causes
constriction of vascular smooth muscle
through an inositol 1,4,5-triphosphate (IP3)
second messenger system?

A

Antidiuretic hormone (ADH)

41
Q

Which of the following substances
acts on its target cells via an inositol 1,4,5
triphosphate (IP3)–Ca2+ mechanism?

A

Oxytocin acting on myoepithelial cells
of the breast

42
Q

A key difference in the mechanism of
excitation–contraction coupling between
the muscle of the pharynx and the muscle of
the wall of the small intestine is that

A

Ca2+ binds to troponin C in the pharynx,
but not in the small intestine, to initiate
contraction

43
Q

norepinephrine inhibits contraction of smooth muscle in the __________

A

intestine

44
Q

norepinephrine stimulates contraction of smooth muscle in ___________

A

blood vessels