Pyruvate Dehydrogenase Flashcards
1
Q
What does TCA cycle do?
A
Converts two-carbon acetyl-CoA into C02 , final stage in the oxidation of metabolic fuels, and consists of eight reactions in a cyclic manner
2
Q
The first step of Pyruvate Dehydrogenase is the ____
A
Decarboxylation of Pyruvate, via Hydroxyethyl-TPP intermediate
3
Q
In step 2, the ____ group is transferred from ___ to ___ forming a ____
A
Hydroxyethyl, E1-TPP, E2-Lipoamide, thioster
4
Q
In step 3, the ____ group is transferred to ____
A
Acetyl, Coenzyme A
5
Q
In step 4, _____ is oxidized by the _____ , regenerating the ______ and reducing the _____
A
Dihydrolipoamide, E3 Cystine, E2 co-factor, E3 disulfide
6
Q
In step 5, the _____ is ___
A
E3 enzyme, regenerated
7
Q
The TCA cycle occurs in ____
A
The mitochondria
