Purine and Pyrimidine Metabolism Flashcards
1
Q
Lesch-Nyhan Syndrome
A
Deficiency in HGPRT
2
Q
Gout
A
Build of of uric acid crystals in joints
3
Q
Amino acids needed for de novo pyridine synthesis
A
Aspartate and glutamine
4
Q
Primary end product of pyrimidine synthesis
A
UMP
5
Q
Inhibitors if ribonucleotide reductase
A
dADP and dATP
6
Q
Rate limiting enzyme of purine synthesis
A
PRPP amidotransferase
7
Q
Inhibitors of PRPP amidotransferase
A
AMP, GMP, IMP
8
Q
Amino acids needed for purine synthesis
A
Aspartate, Glutamine and Glycine
9
Q
Cause of SCID
A
Adenosine Deaminase Deficiency
