Pulmonary pharmacology

Question 1

increasing cAMP levels leads to

Answer 1

smooth muscle relaxation and thus increase bronchodilation

Question 2

Beta1 leads to

Answer 2

increase in heart and contractility

Question 3

tachychardia that occurs with Beta receptors is due to

Answer 3

Beta-1 due to some of the drug swallowed and the blood is able to get into the blood stream

Question 4

the side effect of albuterol, the tremors are caused by

Answer 4

B2

Beta-2 leads to smooth muscle relaxation

Question 5

albuteral is a short/long- acting and quick/slow onset

Answer 5

short-acting and quick acting

Question 6

salmeterol is short/long acting

Answer 6

long acting

Question 7

black-block of long acting beta agonist

Answer 7

increased risk of severe asthma episodes

Question 8

corticosteroids are mainly __________ and they inhibit

Answer 8

anti-inflammatory and inhibit phospholipases

Question 9

where do leukotrienes tend to accumulate?

Answer 9

lungs

Question 10

Dexamethasone

Answer 10

glucocorticoid only

Question 11

inhaled corticosteroids for chronic use

Answer 11

ICS

Question 12

long acting inhaled such as fluticasone can have what type of side effect?

Answer 12

thrush

Question 13

acetylcholine binds to

Answer 13

muscarinic receptors

Question 14

muscarinic antagonist like atrovent leads to

Answer 14

reduced broncoconstriction by prevnting the rise in cAMP

Question 15

atrovent has rich/poor systemic absoption

Answer 15

poor absorption

Question 16

theophylline

Answer 16

while prevents both constriction and dilation it has a narrow therapeutic window and thus toxicity is likely

Question 17

mast cell stabilizers

Answer 17

prevent the release of histamine

Question 18

monoclonal antibodies are used against

Answer 18

allergic asthma

Question 19

what can happen at the injection sie for monoclonal ab.?

Answer 19

hypersensitivity rxn