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PAS 531 > Pulmonary pharm > Flashcards

Pulmonary pharm Flashcards

1
Q

Inhaled NO

A

Vasodilator for pulmonary HTN

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2
Q

Riociguat

A

sGC stimulator for Pulm HTN

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3
Q

Sildenafil
Radalafil

A

PDE5 inhibitors in Pulm HTN
Increase pulm artery vasodilation

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4
Q

Bosentan
Mecitentan

A

Dual endothelic receptor antagonist in pulm HTN.
B is hepatotoxic
M not for preg

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5
Q

Ambrisentan

A

Selective endothelin receptor antagonist in pulm HTN

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6
Q

-prost- and selexipag

A

Prostacyclin analogs for pulm HTN

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7
Q

Sotatercept

A

Pulm HTN
Binds circulating activin A modulating vascular proliferation.

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8
Q

Calcium channel blockers in pulm HTN

A

Nifedipine
Verapimil
Diltiazem

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9
Q

Codeine

A

Acute bronchitis
Antitussive
Converted into morphine by CYP 2D6

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10
Q

hydrocodone

A

Acute bronchitis
Antitussive

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11
Q

Dextromethorphan

A

Acute bronchitis
Antitussive

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12
Q

Benzonatate

A

Acute bronchitis
Antitussive

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13
Q

Diphenhydramine
Promethazine

A

Acute bronchitis
anticholinergic to dry mucous
Crosses BBB
Antitussive

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14
Q

Guaifenesin

A

Acute bronchitis
Mucinex
Loosens mucus to cough up
NOT for preg
NOT for dry cough

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15
Q

Phennol spray
Benzocain/menthol lozenges

A

Acute bronchitis
Local anesthetic/analgesic effects

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16
Q

Adamantanes
Amantidine
Rimantidine

A

Flu A
Block M2 ion channel preventing replicatoin
TETRATOGENIC

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17
Q

-mivir

A

Neuraminidase inhibitors
Flu a and B

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18
Q

Baloxavir

A

Endonuclease inhibitor
Flu
Only on dose needed

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19
Q

Ribavirin

A

RSV
TERATOGENIC
Inhibits viiral mRNA decreasing replicatoin

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20
Q

Plavizumab

A

RSV
Monoclonal antibody

21
Q

Nirsevimab

A

RSV
Monoclonal antibody

22
Q

Nirmatrelvir/ritonavir

A

Covid
N Blocks viral protease
R CYP3A4 inhibitor

23
Q

Molnupiravir

A

Covid
Prodrug
TERATOGENIC

24
Q

Remdesivir

A

Covid
TERATOGENIC

25
Q

Sulfamethoxazole/trimethoprim

A

Fungal pneumonia
Bactrim
21 days for HIV

26
Q

Rifapentine

A

TB
Stops RNA synthesis
CYP450 inducer

27
Q

Isoniazid

A

TB
Disrupts bacterial cell wall
Most active TB drug

28
Q

Pyrazinamide

A

TB
Inhibits fatty acid synthase
TERATOGENIC

29
Q

Moxifloxacin

A

TB fluoroquinolone
Binds topoisomerase
Tendonitis

30
Q

Nonselective beta agonists for asthma

A

Epinephrine
Ephedrine
NOT antiinflammatory

31
Q

SABA

A

Asthma bronchodilator
-uterol
Asthma
NOT antiinflammatory
Binds to beta-2 receptors causing bronchodilation
NOT monotherapy
Onset 5 mins
duration 4-6 hours

32
Q

LABA

A

Asthma bronchodilator
-oterol, -aterol
Asthma
NOT antiinflammatory
Binds to beta-2 rceptors causing bronchodilation
Onset 20 mins
Duration 12-24 hours
Formoterol with ICS onset 2-3 mins so good reliever

33
Q

SAMA

A

Asthma bronchodilator
Ipatropium
Blocks musacarinic receptors causing bronchodilation
ONset 30mins
duration 6-8 hours

34
Q

LAMA

A

Asthma bronchodilator
Tiotropium, aclidinium, umeclidinium, glycopyrrolate, Revefaenacin
Onset 15 misn
Duration 12-24 hrs

35
Q

Theophyline

A

Beta-2 agonist and ICS
Asthma bronchodilation and antiinflammatory

36
Q

ICS

A

Asthma antiinflammatory
-one mostly
Prevent future asthma attacks
Last line for COPD exacerbatino prevention
Late phase rxn to allergen

37
Q

Systemic corticosteroids

A

Prednisone, prednisolone, methylprednisolone
Asthma antiinflammatory
Bad adverse

38
Q

Cromolyn

A

Asthma add-on antiinflammatory
Mast cell stabilizer preventing degranulation

39
Q

Zileuton

A

Asthma add-on
stops 5-lipoxygenase from convertic arachidonic acid into leukotrienes

40
Q

-lukast

A

LTD4 receptor blocker
Add on in asthma
Causes neuropsychiatric effects

41
Q

-zumab

A

Asthma add-on
Monoclonal antibody
Anti IgE
Reduces freq of asthma exacerbations

42
Q

Duplumab

A

Asthma add-on
Blocks IL4 and IL13
Reduces asthma exacerbations

43
Q

Tezepelumab

A

Asthma add-on
Binds to TSLP after release from endothelial cells
Reduces asthma exacerbations

44
Q

pemetrexed
Gemcitabine

A

Lung cancer chemo
S phase of cell cylce

45
Q

Docetaxel
Paclitaxel

A

Lung cancer chemo
M phase of cell cycle
Inhibit microtubules

46
Q

Etoposide

A

Lung cancer chemo
G2 phase stopping ligation

47
Q

Cisplatin
Carbolatin

A

Lung cancer chemo
Works in all phases
Cross links DNA

48
Q

Novolumab
Pembrolizumab
Durvalumab
Atezolizumab

A

Lung cancer immunotherapy
Bind PD-1 on T cellls or PDL-1 on tumor cells to prevent binding so T cells destroy tumor

PAS 531 (15 decks)

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