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PAS 531 > Pulmonary pharm > Flashcards

Pulmonary pharm Flashcards

1
Q

Inhaled NO

A

Vasodilator for pulmonary HTN

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2
Q

Riociguat

A

sGC stimulator for Pulm HTN

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3
Q

Sildenafil
Radalafil

A

PDE5 inhibitors in Pulm HTN
Increase pulm artery vasodilation

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4
Q

Bosentan
Mecitentan

A

Dual endothelic receptor antagonist in pulm HTN.
B is hepatotoxic
M not for preg

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5
Q

Ambrisentan

A

Selective endothelin receptor antagonist in pulm HTN

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6
Q

-prost- and selexipag

A

Prostacyclin analogs for pulm HTN

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7
Q

Sotatercept

A

Pulm HTN
Binds circulating activin A modulating vascular proliferation.

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8
Q

Calcium channel blockers in pulm HTN

A

Nifedipine
Verapimil
Diltiazem

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9
Q

Codeine

A

Acute bronchitis
Antitussive
Converted into morphine by CYP 2D6

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10
Q

hydrocodone

A

Acute bronchitis
Antitussive

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11
Q

Dextromethorphan

A

Acute bronchitis
Antitussive

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12
Q

Benzonatate

A

Acute bronchitis
Antitussive

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13
Q

Diphenhydramine
Promethazine

A

Acute bronchitis
anticholinergic to dry mucous
Crosses BBB
Antitussive

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14
Q

Guaifenesin

A

Acute bronchitis
Mucinex
Loosens mucus to cough up
NOT for preg
NOT for dry cough

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15
Q

Phennol spray
Benzocain/menthol lozenges

A

Acute bronchitis
Local anesthetic/analgesic effects

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16
Q

Adamantanes
Amantidine
Rimantidine

A

Flu A
Block M2 ion channel preventing replicatoin
TETRATOGENIC

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17
Q

-mivir

A

Neuraminidase inhibitors
Flu a and B

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18
Q

Baloxavir

A

Endonuclease inhibitor
Flu
Only on dose needed

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19
Q

Ribavirin

A

RSV
TERATOGENIC
Inhibits viiral mRNA decreasing replicatoin

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20
Q

Plavizumab

A

RSV
Monoclonal antibody

21
Q

Nirsevimab

A

RSV
Monoclonal antibody

22
Q

Nirmatrelvir/ritonavir

A

Covid
N Blocks viral protease
R CYP3A4 inhibitor

23
Q

Molnupiravir

A

Covid
Prodrug
TERATOGENIC

24
Q

Remdesivir

A

Covid
TERATOGENIC

25
Sulfamethoxazole/trimethoprim
Fungal pneumonia Bactrim 21 days for HIV
26
Rifapentine
TB Stops RNA synthesis CYP450 inducer
27
Isoniazid
TB Disrupts bacterial cell wall Most active TB drug
28
Pyrazinamide
TB Inhibits fatty acid synthase TERATOGENIC
29
Moxifloxacin
TB fluoroquinolone Binds topoisomerase Tendonitis
30
Nonselective beta agonists for asthma
Epinephrine Ephedrine NOT antiinflammatory
31
SABA
Asthma bronchodilator -uterol Asthma NOT antiinflammatory Binds to beta-2 receptors causing bronchodilation NOT monotherapy Onset 5 mins duration 4-6 hours
32
LABA
Asthma bronchodilator -oterol, -aterol Asthma NOT antiinflammatory Binds to beta-2 rceptors causing bronchodilation Onset 20 mins Duration 12-24 hours Formoterol with ICS onset 2-3 mins so good reliever
33
SAMA
Asthma bronchodilator Ipatropium Blocks musacarinic receptors causing bronchodilation ONset 30mins duration 6-8 hours
34
LAMA
Asthma bronchodilator Tiotropium, aclidinium, umeclidinium, glycopyrrolate, Revefaenacin Onset 15 misn Duration 12-24 hrs
35
Theophyline
Beta-2 agonist and ICS Asthma bronchodilation and antiinflammatory
36
ICS
Asthma antiinflammatory -one mostly Prevent future asthma attacks Last line for COPD exacerbatino prevention Late phase rxn to allergen
37
Systemic corticosteroids
Prednisone, prednisolone, methylprednisolone Asthma antiinflammatory Bad adverse
38
Cromolyn
Asthma add-on antiinflammatory Mast cell stabilizer preventing degranulation
39
Zileuton
Asthma add-on stops 5-lipoxygenase from convertic arachidonic acid into leukotrienes
40
-lukast
LTD4 receptor blocker Add on in asthma Causes neuropsychiatric effects
41
-zumab
Asthma add-on Monoclonal antibody Anti IgE Reduces freq of asthma exacerbations
42
Duplumab
Asthma add-on Blocks IL4 and IL13 Reduces asthma exacerbations
43
Tezepelumab
Asthma add-on Binds to TSLP after release from endothelial cells Reduces asthma exacerbations
44
pemetrexed Gemcitabine
Lung cancer chemo S phase of cell cylce
45
Docetaxel Paclitaxel
Lung cancer chemo M phase of cell cycle Inhibit microtubules
46
Etoposide
Lung cancer chemo G2 phase stopping ligation
47
Cisplatin Carbolatin
Lung cancer chemo Works in all phases Cross links DNA
48
Novolumab Pembrolizumab Durvalumab Atezolizumab
Lung cancer immunotherapy Bind PD-1 on T cellls or PDL-1 on tumor cells to prevent binding so T cells destroy tumor
49

PAS 531 (15 decks)

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