Public Health 2 Flashcards
Epidemiology
Study of…
- Frequency
- Distribution
- Determinants
…of disease and health
…in populations
… in order to prevent and control disease
Incidence
New cases in a set time period
Prevalence
Existing cases at a given point in time
Person time
Measure of time at risk
From entry to study to…
- Disease onset
- Loss to follow-up
- End of study
Used to calculate incidence rate
Person time is the denominator
Absolute risk
ACTUAL numbers
E.g. 50 deaths per 1000
Relative risk
Risk in one group relative to another
Ratio of risk of disease in exposed to risk of disease in unexposed
Incidence in exposed / incidence in unexposed
RR = 1 = No difference
RR > 1 = Intervention increases risk of outcome
RR < 1 = Intervention decreases risk of outcome
Attributable risk
Rate of disease in the exposed that can be attributed to the exposure
(Incidence in exposed - incidence in unexposed)
ABSOLUTE RISK
Relative risk reduction
RRR
Reduction in rate of outcome in the intervention group relative to control group
Absolute risk reduction
ARR
Absolute difference in the rates of events between the two groups
Gives an indication of baseline risk and intervention effect
Number needed to treat
NNT
Number of patients needed to treat to prevent ONE bad outcome
1 / absolute risk reduction
Reasons for association between exposure and outcome
Bias Chance Confounding Reverse causality True causal association
Bias
Systematic deviation from the true estimation of association between exposure and outcome
Systematic error which leads to a distortion of the true underlying association
Main groups of bias
Selection bias
Information bias
Selection bias
Systematic error
Selection of study participants
Allocation of participants to different groups
Information bias
Systematic error
Measurement or classification of exposure or outcome
Sources of information bias
Observer bias
Recall bias
Instrument
Confounding
A factor that is associated with the exposure in question
Independently influences the outcome
Association and causation considerations
Bias
Chance
Confounding
Criteria for causality
Reverse causality
Association between exposure and outcome
Could be due to outcome causing exposure
Causality criteria
Bradford-Hill
- Strength of association - Magnitude of RR
- Dose-response - Higher exposure = Higher risk
- Consistency - Similar results from different researchers and various study designs
- Temporality - Does exposure precede outcome
- Reversibility - Removal of exposure reduces risk of disease
- Biological plausibility - Biological mechanisms explaining the link
- Coherence - Logical consistency with other information
- Analogy - Similarity with other established cause-effect relationships
- Specificity - Relationship specific to outcome of interest