PTB lecture 5

Question 1

slow release

Answer 1

the release of a drug from the dosage form is prolonged over a longer period of time (>45min)

Question 2

delayed release

Answer 2

the release of a drug from the dosage form will not start immediately after administration, but will only start after a specific lag-time

Question 3

targeted release

Answer 3

the release of a drug will occur at a predetermined site in the GI tract

Question 4

zero-order release profile

Answer 4

release rate is independent from time, drug release is constant during the entire release time

Question 5

first-order release profile

Answer 5

slowly decreasing rate of drug release, in time the drug release will be slower than in the beginning of the drug release (follows the square root of time)

Question 6

pseudo-order profile release

Answer 6

faster release in the beginning of the drug release, after a period of linear drug release we find a decreasing release rate of the drug

Question 7

eroding/rupturing coating

Answer 7

by applying different thicknesses of membrane around spheres, they will erupt at different times

Question 8

absorption window

Answer 8

drug absorption only occurs in specific parts of the GI tract (often in the duodenum)

Question 9

floating systems

Answer 9

based on low density or gas formation (CO2), polymer around drug will form a gel, at the end al powder is wetted

Question 10

expanding systems

Answer 10

systems that grow large in the stomach, and are too large to pass the pylorus in the duodenum

Question 11

targeted release in lower part of intestinal tract prevents….

Answer 11

absorption in higher parts of GI tract

Question 12

ColoPulse coating

Answer 12

prevention that the capsule will not open entirely, and that not all drug will be released