PTB lecture 3 Flashcards
1
Q
pharmacokinetics
A
How the body affects the drug
2
Q
pharmacodynamics
A
how the drug affects the body
3
Q
therapeutic window
A
the area between a minimum dose to have an effect and the maximum dose before intoxication (side effects)
4
Q
intravascular
A
directly into the blood stream
5
Q
extravascular
A
absorption required for systemic effect
6
Q
local
A
not aiming at systemic effect
7
Q
free drug
A
drug not bound to albumin, plasma protein
8
Q
loading dose depends on…
A
volume of distribution
9
Q
maintenance dose depends on…
A
clearance
10
Q
half-life (t1/2)
A
time required to clear 50% of the drug
11
Q
t1/2 depends on…
A
Vd and CL
12
Q
bioavailability
A
fraction of dose reaching the circulation or site of measurement
13
Q
intravascular administration
A
F=1
14
Q
extravascular administration
A
F=<1
15
Q
F=
A
AUC oral/AUC iv
