PTB lecture 4

Question 1

elastic deformation

Answer 1

powder mover back to its previous form

Question 2

forces

Answer 2

used to detect when powder is lubricated

Question 3

attraction forces between solid particles

Answer 3

van der Waals forces

Question 4

larger contact surface results in…

Answer 4

stronger binding

Question 5

strain

Answer 5

deformation or change in a material after an applied force (material stress)

Question 6

ductile

Answer 6

visco-elastic behavior

Question 7

crushing strength (CrS)

Answer 7

force at which the tablet will break

Question 8

friability

Answer 8

not to much powder should wear off a tablet, determined by spinning blade, <1%

Question 9

disintegration of tablets

Answer 9

time required to fall through a sieve with a mesh of 2 mm

Question 10

dissolution of a tablet

Answer 10

time required for a certain drug fraction to dissolve from the tablet

Question 11

binders

Answer 11

polymers that show adhering properties when in contact with water

Question 12

disintegrants

Answer 12

polymers that swell in contact with water, thereby extinct wicking forces and increase the water penetration rate

Question 13

glidants

Answer 13

ball bearing between large particles, enhance the flowability of a powder

Question 14

lubricants

Answer 14

non-binding and non-smearing materials that prevents sticking to the punches and dies (PEG 6000; hydrophilic)