Psychostimulants and ADHD

Question 1

Dopamine levels in the nucleus accumbens are especially important for the reinforcing properties of _______

Answer 1

psychostimulant drugs

Question 2

Cocaine’s mechanism of action is different from amphetamine. Cocaine blocks ______ and increases ______in vesicles for future release.

Answer 2

dopamine reuptake

dopamine storage

Question 3

Behavioural Effects of Psychostimulants

Low doses increase______ behavior

Higher doses increase ______ behavior

Answer 3

purposeful

purposeless

Question 4

Name Adverse Effects of Psychostimulant Use

Answer 4

Cardiovascular dysfunction

Pulmonary dysfunction

Meth mouth (tooth decay in chronic users)

Psychostimulant-induced psychosis

Question 5

Women appear more vulnerable to addiction.
Estrogen is associated with _____ positive effects
Progesterone weakens psychostimulant effects

Answer 5

Increased

Question 6

Name the two primary phases of recovery

Answer 6

Detoxification

Relapse

Question 7

What are the Treatments for Psychostimulant Addiction

Answer 7

Disulfiram (prevents DA –> NE conversion)

Modafinil (mild stimulant)

Tricyclic antidepressants (reduce craving/depression)

Anticonvulsant drugs (facilitate GABA, block learning in addiction)

Question 8

Two dopamine genes, _______ have been reported to be associated with ADHD

Answer 8

DAT1 & DRD4

Question 9

Areas and volumes (in the right hemisphere) where ct was _____ in ADHD individuals than in healthy individuals

Answer 9

Thinner

Question 10

Occipital cortex thickness is ______ in adults with persistent ADHD

Answer 10

Decreased

Question 11

Medication used to treat ADHD include

Answer 11

CNS stimulants

Antidepressants

α2 Adrenoceptor Agonists

Lithium & Anticonvulsants

Anxiolytics & Neuroleptics

Question 12

Whats the mode of action for CNS stimulants?

Answer 12

Mode of action of these agents is to increase the activity of central DA and NA systems