Anxiety and Anxiolytic drugs

Question 1

Name the five different anxiety disorders

Answer 1

Specific phobias
Panic disorder
Agoraphobia
Social anxiety disorder
Generalized anxiety disorder

Question 2

Projections to the _________ mediate physiological responses, and the prefrontal cortex influences how to behave in a given fearful situation.

Answer 2

locus coeruleus and hypothalamus

Question 3

Long-acting barbiturates have _______ that can result in effects not being seen for up to an hour after administration. However, the slow metabolism of these drugs allows the effects to last for up to 12 hours.

Answer 3

poor lipid solubility

Question 4

Ultrashort-acting barbiturates are ________ and are metabolized quickly. Therefore, their effects can be seen within a few minutes but generally only last 30 minutes or so

Answer 4

highly lipid soluble

Question 5

Barbiturates are __________ of the GABAA receptor

Answer 5

positive allostetic modulators (PAM)

Question 6

Sedative-hypnotic properties arise from suppression of _______

Answer 6

cortical functioning and arousal.

Question 7

Benzodiazepines are _____ of the GABAA receptor

Answer 7

positive allostetic modulators (PAM)

Question 8

The _____ is a high affinity site contained in the α1 subunit.

Answer 8

BZ I site

Question 9

The _____ is a lower affinity site contained in α2, α3, and α5 subunits.

Answer 9

BZ II site

Question 10

The effects of benzodiazepines is dependent on the location of where___________

Answer 10

They are operating and the type of BZ binding site most prevalent.