pain and analgesia

Question 1

Name the 5 different Sensory receptors

Answer 1

Mechanoreceptors
Thermoreceptors
Chemoreceptors
Proprioceptors
Nociceptors

Question 2

Name the different kinds of pain

Answer 2

Acute (physiological)
Inflammatory (pathological)
Neuropathic

Question 3

What receptor does local anaesthetics target

Answer 3

Nociceptors

Question 4

Inflammatory pain triggers the release of______

Answer 4

Inflammatory mediators such as Prostaglandins and Bradykinin

and increase the sensitivity of nocipetors to noxious stimuli

Question 5

Clinical significance of Signal transduction in nociceptors

Answer 5

Antagonists block TRPV1 activity, thus reducing pain

Question 6

Opiates decrease pain by modulating the__________ in a complex manner

Answer 6

Descending pain pathway

Question 7

For moderate pain axons release ______, with fast action

Answer 7

Glutamate

Question 8

For stronger pain axons release __________ (and ATP), with slower sustained actions

Answer 8

Glutamate and Substance P

Question 9

What do Local inhibitory interneurons release?

Answer 9

GABA and Glycine

Question 10

Descending pain control fibres release _____ to inhibit pain

Answer 10

Opiods