Psychosis Flashcards

1
Q

Define Psychosis

A

A loss of contact with reality

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2
Q

Define Delusions

A

Strongly held false beliefs that are not part of the patient’s cultural or religious backgrounds

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3
Q

Types of Delusions

A
Persecutory
Grandiose
Erotomanic
Somatic
Delusions of reference
Delusions of control
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4
Q

Define Hallucinations

A

Wakeful experiences of content that is not actually present

Auditory most common

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5
Q

Thought Disorganization

A

Alogia/poverty of content
Thought blocking
Loosening of association
Tangentiality
Clanging or clang association: rhyming words
Word salad: words linked incoherently
Perseravation: repeating words phrases no matter the topic

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6
Q

Differential Diagnosis of Psychotic Disorders

A
Schizophrenia
Bipolar disorder + psychotic features
Major depression + psychotic features
Schizoaffective disorder
Schizophreniform disorder
Brief psychotic disorder
Substance induced psychotic disorder
Delusional disorder
Psychosis secondary to medical condition
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7
Q

Define Schizoaffective Disorder

A

Affective disorder but have psychotic features at a separate time than the affective disorder

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8
Q

Define Schizophreniform Disorder

A

Schizophrenia that doesn’t quite meet the criteria for Schizophrenia

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9
Q

Labs for Psychosis Work-up

A
CBC
CMP
RPR/VDRL
TSH
HIV
UA
Urine drug screen
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10
Q

What is the peak age of schizophrenia?

A

Men: 12-25
Women: 25-35

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11
Q

Items that make schizophrenia difficult to deal with

A

Highly disabling
Persists throughout patient’s life
Poor care & social ostracism
Only 1/2 obtain treatment

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12
Q

DSM-5 Criteria: 2 of the following characteristics during a 1 month period

A

Delusions
Hallucinations
Disorganized speech
Grossly disorganized or catatonic behavior
Negative symptoms
Social or occupational dysfunction
Continuous signs of disturbance persisting for at least 6 months within 1 month of “active-phase” symptoms

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13
Q

Positive Symptoms of Schizophrenia

A

Delusions

Hallucinations

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14
Q

Negative Symptoms of Schizophrenia

A
Affective flattening
Poverty of speech (Alogia)
Blocking
Poor grooming
Lack of motivation
Anhedonia
Social withdrawal
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15
Q

Which types of symptoms have better responses to treatment?

A

Positive symptoms

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16
Q

Subtypes of Schizophrenia

A

Paranoid type
Disorganized type
Catatonic type

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17
Q

Define Paranoid Schizophrenia

A

Preoccupation with one or more delusions or frequent auditory hallucinations
No disorganized speech, disorganized or catatonic behavior, or flat or inappropriate affect

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18
Q

Characteristics of Disorganized Schizophrenia

A

Disorganized speech
Disorganized behavior
Flat or inappropriate affect

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19
Q

Characteristics of Catatonic Schizophrenia

A
Motoric immobility
Excessive purposeless motor activity
Extreme negativism or mutism
Peculiarities of voluntary movement
Echolalia or echopraxia
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20
Q

Define Echolalia & Echopraxia

A

Mimic your movements or your speech

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21
Q

Four Components of Delusions

A

False belief
Based on incorrect inference about external reality
Not consistent with patient’s intelligence & cultural background
Cannot be corrected by reasoning

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22
Q

Name this type of Delusion: “I can’t believe that they’ve now sabotaged my car! Last week they stole my mail and I know they are following me overtime I leave the house”

A

Delusion of Persecution

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23
Q

Name this type of Delusion: “God has chosen me to be the world’s representative at the universal meeting at Mars next month”

A

Delusion of Grandeur

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24
Q

Name this type of delusion: “Invaders from space have infiltrated my testicles so I wouldn’t be allowed to father any children.”

A

Bizarre Delusion

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25
Q

Name this type of delusion: “It doesn’t matter anyway with how my thoughts are controlled by the government.”

A

Delusion of Control

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26
Q

Name this type of delusion: “The DJ is really giving me instructions on what to do. He just disguises it so no one will pick up on it.”

A

Delusion of Reference

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27
Q

Different Thought Form & Process’s

A
Flight of ideas
Thought blocking
Incoherence
Poverty of content
Poor abstraction abilities
Verbigeration
Tangentiality
Circumstantiality
Loose associations
Derailment
Neologisms
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28
Q

Parts of a Mental Status Examination

A
General description
Mood, feelings, affect
Perception
Thought: content, form & process
Sensorium & cognition: oriented x3, memory intact, poor insight
Impulsiveness
29
Q

Neurotransmitters Associated with Schizophrenia

A
Dopamine
Glutamate
Gamma-amino-butyric-acid (GABA)
Acetylcholine
Serotonin
30
Q

Dopamine in Schizophrenia

A

Decreased dopamine: cognitive & negative symptoms

31
Q

Glutamate in Schizophrenia

A

Major CNS excitatory neurotransmitter

Hypofunction of glutamate receptor may contribute to pathology

32
Q

Gamma-amino-butyric-acid (GABA) in Schizophrenia

A

Major CNS inhibitory neurotransmitter
Important for regulation of the prefrontal cortical function
Interneurons are dysfunction in schizophrenia

33
Q

Acetylcholine in Schizophrenia

A

Nicotine can normalize some eye-tracking & EEG abnormalities

34
Q

Serotonin in Schizophrenia

A

Antagonism at 5-HT2 receptors reduces psychotic symptoms

35
Q

Pattern of Symptoms in Schizophrenia

A

Quiet, passive, & introverted personality
Few friends growing up
Adolescents may have no close friends, dates, & may avoid team sports
Enjoy movies & TV or listening to music instead of social activities

36
Q

Poor Outcomes of Schizophrenic Patients

A

Repeated hospitalizations
Exacerbation of symptoms
Episodes of major mood disorders
Suicide attempts

37
Q

What is common among untreated schizophrenic patients?

A

Violent behavior

38
Q

What percent of schizophrenic patients attempt suicide?

A

50%

39
Q

How is Schizoaffective Disorder Different from Schizophrenia

A

Major depressive or manic episode

AND patient must have experienced delusions or hallucinations IN THE ABSENCE of the mood symptoms

40
Q

How is Brief Psychotic Disorder Different from Schizophrenia

A

Symptoms of delusions, hallucinations, disorganized speech, or disorganized behavior that persist for more than 1 day but less than 1 month

41
Q

How is Delusional Disorder Different from Schizophrenia?

A

Delusion WITHOUT other signs/symptoms of psychosis

Delusions are non bizarre

42
Q

How is Schizophreniform Disorder Different from Schizophrenia?

A

Schizophrenia like symptoms for more than 1 month but less than 6 months

43
Q

Examples of First Generation Antipsychotics (FGAs)

A

Haloperidol (Haldol)
Chlorpromazine (Thorazine)
Thioridazine (Mellaril)

44
Q

MOA of First Generation Antipsychotics (FGAs)

A

Antagonism of D2 receptors in both cortical & stratal areas

45
Q

SE of First Generation Antipsychotics (FGAs)

A
Extra-pyramidal symptoms (EPS)
Tardive dyskinesia (TD)
Hyperprolactinemia
Neuroleptic malignant syndrome (NMS)
QT prolongation
Sudden death
Increased risk of mortality when treating elderly patients with dementia
Akinesia
Weight gain
46
Q

Extra-pyramidal Symptoms

A

Akathisia
Parkinsonian syndrome
Acute dystonias

47
Q

Examples of Second Generation Antipsychotics (SGAs)

A

Respirdone (Resperdol)

Aripiprazole (Abilify)

48
Q

MOA of Second Generation Antipsychotics (SGAs)

A

Post-synaptic blockade D2 receptors PLUS 5HT2 receptor binding

49
Q

SE of Second Generation Antipsychotics (SGAs)

A
Weight gain
Hyperglycemia
Hyperlipidemia
EPS
TD
NMS- neuromalignant syndrome
Hyperprolactinemia
Increased mortality in elderly patients with dementia
50
Q

Primary Use of FGAs

A

IV for emergent situations

Depot preparations

51
Q

SE of Risperidone (Risperdal)

A
Sedation
Hypotension
Akathisia
Prolactin elevation
Weight gain
52
Q

SE of Olanzapine (Zyprexa)

A
Weight gain
Sedation
Akathisia
Hypotension
Dry mouth
Constipation
53
Q

What is quetiapine (Seroquel) used to treat?

A

Mood disorders
Anxiety disorders
PTSD
Parkinson disease

54
Q

SE of Quetiapine (Seroquel)

A
Sedation
Orthostatic hypotensions
Akathisia
Dry mouth
Weight gain
55
Q

Pharmacokinetics of Aripipraole (Abilify)

A

Agonist at D2 receptors
Partial agonist at 5HT1a receptors
Antagonist at 5HT2a, H1 & alpha-1-adrenergics

56
Q

SE of Aripipraole (Abilify)

A
Headache
N/V
Akathisia
Tremor
Constipation
Minimal weight gain
57
Q

What does clozapine (Clozaril) have a high risk of?

A

Agranulocytosis

58
Q

When do we use clozapine (Clozaril)?

A

Treatment-Resistant patients

59
Q

SE of Clozapine (Clozaril)

A
Orthostatic hypotension
Tachycardia
Weight gain
Metabolic syndrome
Sialorrhea
Sedation
Constipation
Seizure risk that increases with dose
60
Q

How to treat akathisia as a SE of antipsychotics?

A

Benzodiazepine
Beta-blocker
Benztropine

61
Q

How to treat parkinsonian syndrome as a SE of antipsychotics?

A

Benztropine

Amantadine: SE hypotension & mild agitation

62
Q

How to treat dystonia as a SE of antipsychotics?

A

Change to antipsychotics with lower EPS
Benztropine
Diphenhydramine

63
Q

Tardive Dyskinesia Movements

A
Sucking/smacking lips
Choreaoathetoid movement of tongue
Facial grimacing
Lateral jaw movements/clenching
Choreiform or athetoid movements of the body
64
Q

Risk Factors for Tardive Dyskinesia

A

Long use of antipsychotics
EPS
Elderly
Use of other meds

65
Q

Metabolic Effects of Antipsychotics

A

Weight gain
Hyperglycemia
Hyperlipidemia
NMS: fever, mental status changes, rigidity, autonomic instability

66
Q

Treatment Options in Addition to Medication for Schizophrenia

A

Family psychoeducational intervention
Social skills training for the patient
Cognitive behavioral therapy

67
Q

Family Psychoeducational Intervention

A

Educates family that schizophrenia is a disease, factors about the disease, how to help the person with the disease & fosters optimism
Monthly sessions for 6-9 months

68
Q

Social Skills Training for the Patient

A

Uses behaviorally based instruction, role modeling, rehearsal, corrective feedback, & positive reinforcement
Helps with deficits in skills as a result of negative symptoms

69
Q

Cognitive Behavioral Therapy

A

Used to treat medication-resistant psychosis