Psych Meds in Pregnancy & Lactation Flashcards

1
Q

Risks for Psychiatric Disorders

A

Mood disorders
Anxiety disorders
Psychotic disorders

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2
Q

Risks for a Fetus with Untreated Disorders

A
Preterm delivery
Lower birth weight
Spontaneous abortion
Pre-eclamsia
Instrumental deliveries
Operative deliveries
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3
Q

Neonatal Outcomes of Untreated Disorders

A
Poor neonatal adaptation
Increased risk of NICU admission
Growth retardation
Lower APGAR scores
Decreased head circumference
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4
Q

Child Development of Untreated Disorders

A
Negative effect on fetal-maternal bonding
Difficulty with affect regulation
Cognitive delays
Maladaptive social interactions
Increased levels of anxiety & fear
Increased levels of ADHD
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5
Q

Risk to Mother with an Untreated Disorder

A

Poor nutrition
Impaired self care
Failure to follow medical/prenatal guidelines
Worsening of co-morbid medical illness
Increased exposure to ETOH, tobacco, & drugs
Impact on family
Postpartum psychiatric complications

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6
Q

Treatment Options for Mental Disorders

A
Psychosocial
Psychotherapy
Massage
Light Therapy
Exercise
ECT
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7
Q

Key Concepts in Pregnancy for Pharmacotherapy

A

Placental barrier: lipid solubility, molecular weight, ionization
Safe period
Pharmacokinetics: physiologic changes, increased plasma volume, glomerular filtration, action of liver microsomal activity, protein binding, slowing of gastric motility
Drug safety data
US FDA pregnancy categories

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8
Q

Antidepressant Therapy

A

TCAs: amitriptyline, nortriptyline, desipramine
SNRIs: venlafaxine (Effexor), duloxetine (Cymbalta)
Bupropion (Wellbutrin)
Trazodone
Mirtazipine (Remeron)

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9
Q

Symptoms of SSRI or SNRI Withdrawal in the Neonatal

A

Tremor
Restlessness
Increased muscle tone
Increased crying

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10
Q

Issues in the Fetus when Mom is on Lithium

A

Epstein’s anomaly (tricuspid valve)
Floppy baby syndrome
Neonatal hypothyroidism
Nephrogenic DI

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11
Q

Mood Stabilizers

A
Lithium
Lamotrigene (Lamictal)
Valproate (Depakote)
Carbamazepine (Tegretol)
Oxcarbazepine (Trileptal)
Gabapentin (Neurontin)
Topiramate (Topamax)
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12
Q

Valproate (Depakote)

A

Human teratogen: neural tube defects, irritability, jitteriness, feeding problems, growth retardation, lower IQ scores

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13
Q

Carbamazepine (Tegretol)

A

Human teratogen: craniofacial defects, developmental delays, fingernail hypoplasia, neural tube defects
Decrease birth weight
Decreased head circumference

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14
Q

Antipsychotics

A
Phenothiazines & butyrophenones
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Ziprasidone (Geodon)
Aripiprazole  (Abilify)
Clozapine (Clozaril)
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15
Q

Neonatal Withdrawal Syndrome with Benzodiazepines

A
Tremor
Irritability
Diarrhea
Vomiting
Hypertonicity
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16
Q

Benzodiazepines

A

Clonazepam (Klonopin)
Lorazepam (Ativan)
Alprazolam (Xanax)
Diazepam (Valium)

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17
Q

Sedative/Hypnotics

A

Zolpidem (Ambien)
Zaleplon (Sonata)
Eszopiclone (Lunesta)

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18
Q

Benefits of Lactation for the Infant

A
SIDS
GI problems
Anemia
Respiratory ailments
Otitis media
Obesity
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19
Q

Key Principles of Pharmacotherapy in Lactation

A
Low oral bioavailability unlikely to cause systemic effects
Drugs enter breast milk via diffusion
Lipid solubility
Protein binding
Molecular weight
pH
Establishment of milk production
Neonatal physiology
Safety in pregnancy doesn't equal to safety in lactation
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20
Q

Risk Categories in Lactation

A
L1: safest
L2: safer, remote risk
L3: moderately safe, risk possible
L4: possibly hazardous, positive evidence of risk
L5: contraindicated
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21
Q

Sertraline (Zoloft) Lactation Category (SSRI)

A

L2

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22
Q

Fluoxetine (Prozac) Lactation Category (SSRI)

A

L2

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23
Q

Amitriptyline (Elavil) Lactation Category (TCA)

A

L2

24
Q

Imipramine (Tofranil) Lactation Category (TCA)

A

L2

25
Q

Nortriptyline (Pamelor) Lactation Category (TCA)

A

L2

26
Q

Venlafaxine (Effexor) Lactation Category (SNRI)

A

L3

27
Q

Duloxetine (Cymbalta) Lactation Category (SNRI)

A

L3

28
Q

Mirtazipine (Remeron) Lactation Category

A

L3

29
Q

Bupropion (Wellbutrin) Lactation Category

A

L3

30
Q

Trazodone Lactation Category

A

L2

31
Q

Lithium Lactation Category (Mood Stabilizer)

A

L3

32
Q

Lamotrigene (Lamictal) Lactation Category (Mood Stabilizer)

A

L3

33
Q

Carbamazapine (Tegretol) Lactation Category (Mood Stabilizer)

A

L2

34
Q

Valproic acid (Depakote) Lactation Category (Mood Stabilizer)

A

L2

35
Q

Gabapentin (Neurontin) Lactation Category (Mood Stabilizer)

A

L2

36
Q

Oxacarbazepine (Trileptal) Lactation Category (Mood Stabilizer)

A

L3

37
Q

Topiramate (Topamax) Lactation Category (Mood Stabilizer)

A

L3

38
Q

Chlorpromazine (Antipsychotic) Lactation Category

A

L3

39
Q

Perphenazine (Antipsychotic) Lactation Category

A

L3

40
Q

Haloperidol (Haldol) Lactation Category (Antipsychotic)

A

L2

41
Q

Quetiapine (Seroquel) Lactation Category (Antipsychotic)

A

L2

42
Q

Olanzapine (Zyprexa) Lactation Category (Antipsychotic)

A

L2

43
Q

Ziprasidone (Geodon) Lactation Category (Antipsychotic)

A

L2

44
Q

Risperidone (Risperdal) Lactation Category (Antipsychotic)

A

L3

45
Q

Aripiprazole (Abilify) Lactation Category (Antipsychotic)

A

L3

46
Q

Clozapine (Clozaril) Lactation Category (Antipsychotic)

A

L3

47
Q

Alprazolam (Xanax) Lactation Category (Benzo)

A

L3

48
Q

Clonazepam (Klonopin) Lactation Category (Benzo)

A

L3

49
Q

Diazepam (Valium) Lactation Category (Benzo)

A

L3

L4: chronic use

50
Q

Lorazepam (Ativan) Lactation Category (Benzo)

A

L3

51
Q

Eszopiclone (Lunesta) Lactation Category (Hypnotic)

A

L2

52
Q

Zaleplon (Sonata) Lactation Category (Hypnotic)

A

L2

53
Q

Zolpidem (Ambien) Lactation Category (Hypnotic)

A

L2

54
Q

Barriers to Treatment

A

Attitudinal: stigma, unacceptability of treatment, guilt, anxiety, financial

55
Q

Risk vs. Benefit Analysis

A

Maternal psychiatric history
Potential deleterious effects of untreated illness
Information about medication