Psych Meds in Pregnancy & Lactation Flashcards
Risks for Psychiatric Disorders
Mood disorders
Anxiety disorders
Psychotic disorders
Risks for a Fetus with Untreated Disorders
Preterm delivery Lower birth weight Spontaneous abortion Pre-eclamsia Instrumental deliveries Operative deliveries
Neonatal Outcomes of Untreated Disorders
Poor neonatal adaptation Increased risk of NICU admission Growth retardation Lower APGAR scores Decreased head circumference
Child Development of Untreated Disorders
Negative effect on fetal-maternal bonding Difficulty with affect regulation Cognitive delays Maladaptive social interactions Increased levels of anxiety & fear Increased levels of ADHD
Risk to Mother with an Untreated Disorder
Poor nutrition
Impaired self care
Failure to follow medical/prenatal guidelines
Worsening of co-morbid medical illness
Increased exposure to ETOH, tobacco, & drugs
Impact on family
Postpartum psychiatric complications
Treatment Options for Mental Disorders
Psychosocial Psychotherapy Massage Light Therapy Exercise ECT
Key Concepts in Pregnancy for Pharmacotherapy
Placental barrier: lipid solubility, molecular weight, ionization
Safe period
Pharmacokinetics: physiologic changes, increased plasma volume, glomerular filtration, action of liver microsomal activity, protein binding, slowing of gastric motility
Drug safety data
US FDA pregnancy categories
Antidepressant Therapy
TCAs: amitriptyline, nortriptyline, desipramine
SNRIs: venlafaxine (Effexor), duloxetine (Cymbalta)
Bupropion (Wellbutrin)
Trazodone
Mirtazipine (Remeron)
Symptoms of SSRI or SNRI Withdrawal in the Neonatal
Tremor
Restlessness
Increased muscle tone
Increased crying
Issues in the Fetus when Mom is on Lithium
Epstein’s anomaly (tricuspid valve)
Floppy baby syndrome
Neonatal hypothyroidism
Nephrogenic DI
Mood Stabilizers
Lithium Lamotrigene (Lamictal) Valproate (Depakote) Carbamazepine (Tegretol) Oxcarbazepine (Trileptal) Gabapentin (Neurontin) Topiramate (Topamax)
Valproate (Depakote)
Human teratogen: neural tube defects, irritability, jitteriness, feeding problems, growth retardation, lower IQ scores
Carbamazepine (Tegretol)
Human teratogen: craniofacial defects, developmental delays, fingernail hypoplasia, neural tube defects
Decrease birth weight
Decreased head circumference
Antipsychotics
Phenothiazines & butyrophenones Olanzapine (Zyprexa) Quetiapine (Seroquel) Risperidone (Risperdal) Ziprasidone (Geodon) Aripiprazole (Abilify) Clozapine (Clozaril)
Neonatal Withdrawal Syndrome with Benzodiazepines
Tremor Irritability Diarrhea Vomiting Hypertonicity
Benzodiazepines
Clonazepam (Klonopin)
Lorazepam (Ativan)
Alprazolam (Xanax)
Diazepam (Valium)
Sedative/Hypnotics
Zolpidem (Ambien)
Zaleplon (Sonata)
Eszopiclone (Lunesta)
Benefits of Lactation for the Infant
SIDS GI problems Anemia Respiratory ailments Otitis media Obesity
Key Principles of Pharmacotherapy in Lactation
Low oral bioavailability unlikely to cause systemic effects Drugs enter breast milk via diffusion Lipid solubility Protein binding Molecular weight pH Establishment of milk production Neonatal physiology Safety in pregnancy doesn't equal to safety in lactation
Risk Categories in Lactation
L1: safest L2: safer, remote risk L3: moderately safe, risk possible L4: possibly hazardous, positive evidence of risk L5: contraindicated
Sertraline (Zoloft) Lactation Category (SSRI)
L2
Fluoxetine (Prozac) Lactation Category (SSRI)
L2