Psychopharmacology Drug Classes Flashcards
What are some of the most popular first generation (conventional/typical/neuroleptic) antipsychotic medications?
- Chlorpromazine (Thorazine)
- Haloperidol (Haldol)
- Fluphenazine (Prolixin)
- Perphenazine (Trilafon)
suffix -azine
What are some of the most popular second generation (atypical/novel) antipsychotic medications?
- Clozapine (Clozaril)
- Risperidone (Risperdal)
- Olanzapine (Zyprexa)
- Quetiapine (Seroquel)
- Ziprasidone (Geodon)
suffix -pine or -done
True or False: The atypical antipsychotics are more effective at treating negative/social/cognitive psychotic symptoms than the typical antipsychotics.
False - There is no significant difference in effectiveness in treating negative symptoms; however, the atypical antipsychotics have fewer side effects, but usually cost more too.
Mechanism of action : antipsychotics?
Block DA receptors so that DA is taken back up so there will be LESS DA in the brain.
What other conditions might use antipsychotics?
Other psychotic disorders (Brief Psychotic, Schizoaffective); mania or mixed episodes of Bipolar; Delirium; Tourette’s; Autism; pervasive developmental disabilities; PTSD; Major Depression
What are the common side effects of antipsychotics?
- Sedation
- Drowsiness
- Dizziness upon standing (orthostatic hypotension)
- Anticholinergic effects (dry mouth, dry eyes)
- Weight gain
- Sexual dysfunction
- Movement symptoms (Dystonia, Parkinsonism, Tardive Dyskinesia)
- Metabolic adverse effects
- Nueroleptic Malignant Syndrome, rare but lethal
Clozaril - associated with agranulocytosis which is a dangerously low white blood cell count, rare but lethal
What are some popular SSRIs?
- Sertraline (Zoloft)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
suffix -ine
What are some popular SNRIs?
- Venlafaxine (Effexor)
suffix -ine
What are some popular Tricyclic antidepressants?
- Amitriptyline (Elavil)
- Clomipramine (Anafranil)
- Imipramine (Tofranil)
suffix -amine
What are some popular MAOIs?
- Tranylcypromine (Parnate)
- Phenelzine (Nardil)
suffix -ine
What are some popular atypical/other classified antidepressants?
- Bupropion (Wellbutrin) - works predominately on DA
- Mirtazapine (Remeron)
- Trazodone (Desyrel)
be careful not to lump Mirtazapine or Trazodone into antispsychotics
Which are the most dangerous antidepressant class?
Tricyclics
Which antidepressant class has dangerous interactions with food and medications?
MAOIs
Mechanism of Action : antidepressants?
Most block re-uptake of 5HT or NE so there will be MORE in the brain.
What are the common side effects of SSRIs?
- Headaches
- Insomnia
- GI problems
- Sexual dysfunction
- Suicidal thinking in kids and teens