Psychopharmacology Flashcards
What is important to establish before prescribing a medication for psychiatric problem?
Diagnosis
target symptoms - monitor therapy response
How to select the agent and dose
acceptable side effect profile
lowest effective dose
been on medication before which worked
PMH
Indications for anti-depressants
unipolar and bipolar depression
organic mood disorders
schizoaffective disorder
anxiety disorders - OCD, panic, social phobia, PTSD
How long is the delay after therapeutic dose is achieved and symptoms improving?
3-6 weeks
If no improvement after 2 months of adequate dose what should be done?
switch to another antidepressant or augment with another agent
Classifications of antidepressants
TCAs MAOIs SSRIs SNRIs Novel antidepressants
3 potentially unacceptable side effect profile of TCAs
anticholinergic
antihistaminic
antiandrenergic
Caution with prescribing even a weeks dose of TCAs
lethal in overdose
can cause QT lengthening
Why do TCAs have the 3 side effect profile?
tertiary side chains cross react with other types of receptors
antihistaminic side effects
sedation and weight gain
anticholinergic side effects
dry mouth
dry eyes
constipation
memory deficits and delirium
Anti adrenergic side effects
orthostatic hypotension
sedation
sexual dysfunction
tertiary TCAs receptors
predominantly serotonin
Examples of tertiary TCAs
imipramine
amitriptyline
clomipramine
Where do secondary TCAs arise from?
metabolites of tertiary TCAs
primary action of secondary TCAs
block noradrenaline
Examples of secondary TCAs
desipramine
nortriptyline
How do MAOIs work?
bind irreversibly, preventing inactivation of amines eg Norepinephrine, dopamine and serotonin
What are MAOI’s very effective for?
depression
Side effects of MAOIs
orthostatic hypotension weight gain dry mouth sedation sexual dysfunction sleep disturbance
Hypertensive crisis occurs with which meds and when?
MAOIs
taken with tyramine rich foods or sympathomimetics
cheese reaction
Serotonin syndrome occurs with which meds and when?
MAOI and meds that increase serotonin or sympathomimetics
Serotonin syndrome symptoms
abdominal pain diarrhoea sweats tachycardia HTN myoclonus irritability delirium death
How to avoid serotonin syndrome
wait 2 weeks before SSRI –> MAOI (fluoxetine is 5 weeks)
How do SSRIs work?
block presynaptic serotonin reuptake
Side effects of SSRIs
GI upset sexual dysfunction * anxiety restlessness nervousness insomnia fatigue or sedation dizziness
What do SSRIs treat?
anxiety and depression
Discontinuation syndrome of SSRIs
agitation
nausea
dysphoria
Name some SSRIs
paroxetine sertraline fluoxetine citalopram escitalopram fluvoxamine
How o SNRIs work?
block both serotonin and noradrenergic reuptake like TCAs
Positives of SNRIs compared to TCAs
no anti cholinergic, histaminic or adrenergic side effects
SNRIs uses
depression
anxiety
neuropathic pain
Examples of SNRIs
venlafaxine
duloxetine