Child and adolescent psychiatry 1 Flashcards
How to determine the link between genetic factors and mental illness
twin studies - MZ and DZ
% variance due to genetics and environment
Variance in PKU
100% genetics
environmental factor is causative factor (PKU)
What have genetic factor studies shown?
ADHD and autism highly genetic
depression and anxiety substantially genetic
GWAS - main findings
genetic risk factors for psychiatric disorder
many genes implicated
micro RNA and epigenetic
synapses
Intra-uterine and perinatal factors
drugs and toxins maternal ab, obesity, diabetes premature birth twinning epigenetics - folate controlled methylation endocrine - androgens alcohol
Signs of fetal alcohol syndrome
small head, eyes, body and brain - cerebellum
smooth philtrum
growth retardation
fetal alcohol syndrome: neuro developmental effects
sensorimotor cognitive developmental executive function language
Working memory white matter connectivity
hippocampus and anterior cingulate
What is low connectivity in the white matter associated with?
neural “noise”
intra-individual variability
cognitive instability
Developing brain low white matter connectivity
ADHD - poor concentration
distractibility
Common outcomes of low white matter connectivity and grey matter gyrification
learning difficulties
conduct disorders eg ODD
combines ADHD or ADD
anxiety disorders
ODD symptoms
frequent loss of temper
arguing
becoming easily angered or annoyed
showing vindictive behaviour
ADD symptoms
distractibility
sustaining attention to tasks that don’t provide stimulation or reward
problems with organisation
Hyp/imp symptoms
difficulties with remaining still
impulsivity
without considering consequences
Examples of anxiety disorders
panic disorder
phobia
separation anxiety
GAD