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CAP PRITE > Psychopharmacology > Flashcards

Psychopharmacology Flashcards

1
Q

What pharmacokinetic factor of psychotropic medication is different in children from adults?

A

Faster metabolism in children

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2
Q

Pharmacokinetic feature of lamotrigine causing interactions with valproate and carbamazepine? hepatic

A

glucuronidation/metabolism

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3
Q

What consideration should be taken for an ultra-rapid metabolizer of CYP2D6 being prescribed atomoxetine?

A

Higher dose may be needed

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4
Q

Children often require a larger dose compared to adults due to what weight-adjusted characteristic?

A

Higher GFR

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5
Q

Term for proportion of medication taken that reaches systemic circulation?

A

Bioavailability

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6
Q

Which medication may lead to toxicity in children due to its zero order kinetics?

A

Paroxetine

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7
Q

Some medications for psychiatric conditions may seem to lack efficacy in youth due to which factor in youth?

A

Relatively immature neural networks

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8
Q

Best way to monitor emerging diabetes for patients on atypical antipsychotic?

A

Fasting Glucose

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9
Q

Obtain baseline and follow up serum prolactin for which medication?

A

Olanzapine

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10
Q

What is shown to reduce weight gain in antipsychotic use?

A

Metformin

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11
Q

Adolescent male with developmental disability gets IM shot for aggression, then develops twisting of neck with pain. What receptor is blocked?

A

D2

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12
Q

Most likely neuronal tract involved in milky discharge from breast of patient on risperidone?

A

Tubero-infundibular

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13
Q

Which receptor site provides some therapeutic effects of second-gen antipsychotics?

A

5-HT 2A

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14
Q

Lab test for adolescent on aripiprazole for 3 months and no reported side effects?

A

Fasting total cholesterol

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15
Q

First-line treatment for patient just started antipsychotic who can’t stay seated and has new onset restlessness?

A

Propranolol

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16
Q

What medication is appropriate for an adolescent who has akathisia without dystonia?

A

Propanolol

17
Q

Which drug increases serum levels of dextromethorphan/Risperdal due to interactions with CYP2D6 system? (2x)

A

Prozac

18
Q

Why do SSRIs take time?

A

Desensitization of presynaptic 5HT1A receptors

19
Q

Antidepressant with most potent inhibition of CYP450 2D6?

A

Fluoxetine

20
Q

Most likely reason for relapse of symptoms in adolescent with OCD who was previously stable on 200mg of Fluvoxamine?

A

Starting nicotine use

21
Q

Patient on paroxetine wants to taper off. Previous taper attempts failed (dizziness, fatigue, irritability, paresthesias). Cross taper to, then discontinue off which antidepressant?

A

Fluoxetine

22
Q

Contraindicated antidepressant in patient with epilepsy due to lower seizure threshold?

A

Bupropion

23
Q

Medication that is less effective in children due to immature brain noradrenergic pathways?

A

TCAs

24
Q

Most important interaction between ibuprofen and lithium?

A

Nausea and vomiting

25
Q

What should be monitored in first 6 months of starting Lithium?

A

Thyroid-stimulating hormone (TSH) at initiation and at every 3 months

26
Q

New serum test to monitor GFR in patients on lithium maintenance?

A

Cystatin-C

27
Q

At what time should you get a lithium level?

A

Morning, 12 hours after last dose

28
Q

Why does lithium have a lower plasma concentration in children vs adults?

A

Higher volume of distribution

29
Q

Important Oxcarbazepine side effects in adolescent?

A

Hyponatremia

30
Q

Adolescent with hepatic insufficiency. Best mood stabilizer?

A

Topiramate

31
Q

Adolescent on oral contraceptive has an unexpected pregnancy after starting what new medication?

A

Topiramate

32
Q

What is the mechanism of action of Lamotrigine?

A

Inhibition of 5HT3 and release of aspartate and glutamate

33
Q

Psychostimulants stimulate the release of which neurotransmitter?

A

Norepinephrine

34
Q
A

CAP PRITE (60 decks)

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