psychopharm5 Flashcards
when do EPS occur
with high potency traditional antipsychotics;
main differences between EPS and tardive dyskinesia
EPS occurs within days of starting meds, EPS are reversible; TD occurs after years of antipsych use, can be irreversible
how can EPS be life threatening
dystonia of the diaphragm causing asphyxiation
hyperprolactinemia is a SE of what
high potency traditional antipsychotics and risperidone
Neuroleptic malignant syndrome
med emergency with 20% mortality rate; fever, tachycarda, hypertension, tremor, elevated CPK, lead pipe rigidity
which antipsychotics cause neuroleptic malig syndrome?
any, but more likely in high potency traditional antipsychotics
drugs that induce cyp 450
smoking, carbamazepine, barbiturates, st johns wort
drugs that inhibit cyp 450
fluvoxamine, fluoxetine, paroxetine, deloxetine, sertraline
most antidepressants require how long to see an effect?
3-4 weeks
most antidepressants have a withdrawal phenomenon. What is this phenomenon?
dizziness, headaches, nausea, insomnia, and malaise
how do SSRIs work?
inhibit the presynaptic serotonin pumps that take up seratonin
most SSRIs are dosed daily. Which SSRI has a weekly dosing form available?
fluoxetine
why are SSRIs the most commonly prescribed antidepressants?
low incidence of side effects, most of which resolve with time; no food restrictions; much safer in overdose
examples of SSRIs
fluoxetine, fluvoxetine, sertraline, paroxetine, citalopram, escitalopram
