Psychiatry

Question 1

Neurotransmitters in Huntington’s

Answer 1

Decreased GABA, ACh

Increased dopamine

Question 2

Neurotransmitters in Parkinson’s

Answer 2

Decreased dopamine

Increased serotonin and ACh

Question 3

Schizoaffective disorder

Answer 3

At least two weeks of stable mood with psychotic symptoms, plus a major depressive, manic or mixed episode

Question 4

Cyclothymic disorder

Answer 4

Dysthymia (chronic depression) and hypomania. A milder form of bipolar disorder lasting at least two years

Question 5

Clomipramine

Answer 5

TCA specific for OCD

Question 6

Conversion disorder

Answer 6

1) Sudden loss of sensory or motor function following an acute stressor
2) Patient is aware, yet indifferent

Question 7

Schizotypal personality

Answer 7

Eccentric appearance, odd beliefs or magical thinking, interpersonal akwardness

Question 8

Nalaxone + buprenorphine

Answer 8

1) Partial agonist which is long acting with fewer withdrawal symptoms than methadone
2) Withdrawal symptoms only if injected

Question 9

Typical Antipsychotics

Answer 9

1) Haloperidol and “azines”
2) Block dopamine D2 receptors -> increased cAMP
3) Stored in fat, slow to leave body

Question 10

Chlorpromazine, thioridazine

Answer 10

Low potency typical anti-psychotics with anticholinergic, antihistamine and alpha1-blockade effects

Question 11

Trifluoperazine, fluphenazine, haloperidol

Answer 11

High potential typical anti-psychotics with neurologic side effects

Question 12

Treatment of serotonin syndrome

Answer 12

Cyproheptadine

Question 13

Venlafaxine

Answer 13

1) Inhibits serotonin and NE uptake

2) Depression, anxiety, peripheral neuropathy

Question 14

Imipramine

Answer 14

TCA used for bedwetting

Question 15

TCA toxicity

Answer 15

1) Confusion
2) Cardiotoxicity
3) Coma
4) Convulsions

Question 16

Trazodone

Answer 16

1) Used for insomnia

2) Priapism