Equations Flashcards
1
Q
Volume of distribution
A
Amount of drug in body/ plasma drug concentration
2
Q
Half-life
A
(0.7 x Vd)/CL
3
Q
Drug clearance
A
1) Rate of drug elimination/ plasma drug concentration
2) Vd x Ke (elimination constant)
4
Q
Loading dose
A
LD = Cp x Vd/F (bioavailability)
5
Q
Maintenance dose
A
MD = Cp x CL/F
6
Q
Stroke volume
A
End diastolic volume - end systolic volume
7
Q
Ejection fraction
A
SV/ end diastolic volume
8
Q
Renal clearance
A
Cx=UxV/Px
1) Inulin/creatinine used for GFR
2) PAH used for effective renal blood flow
9
Q
Renal blood flow
A
RPF/ (1-HCT)
10
Q
Filtration fraction
A
GFR/RPF
11
Q
Physiologic dead space
A
VT x (PaCO2 - PECO2)/PaCO2
12
Q
Pulmonary vascular resistance
A
PVR = P (pulmonary artery) -P (left atrium)/ CO
13
Q
Alveolar gas equation
A
PAo2 = PIO2 - (PaCO2/R) PAo2 = 150- PaCO2/0.8
