Cancer

Question 1

HER2/neu (c-erbB2)

Answer 1

1) Breast, ovarian and gastric carcinoma

2) Pro-onchogene -> tyrosine kinase

Question 2

Ras

Answer 2

1) Colon cancer
2) GTPase
3) Pro-oncogene

Question 3

RET

Answer 3

1) MEN 2A/2B
2) Tyrosine kinase
3) Pro-oncogene

Question 4

c-kit

Answer 4

1) Gastrointestinal stromal tumor (GIST)
2) Cytokine receptor
3) Pro-oncogene

Question 5

p-16

Answer 5

1) Tumor suppressor gene

2) Melanoma

Question 6

BRAF

Answer 6

1) Tumor suppressor gene

2) Melanoma

Question 7

DPC4

Answer 7

1) Tumor suppressor gene

2) Pancreatic cancer

Question 8

DCC

Answer 8

1) Tumor suppressor gene

2) Colon cancer

Question 9

s-100

Answer 9

Tumor marker for melanoma, neural tumors, schwannomas

Question 10

CA 19-9

Answer 10

Tumor marker for pancreatic cancer

Question 11

Vinyl chloride

Answer 11

Angiosarcoma of the liver

Question 12

Carbon tetrachloride

Answer 12

Centrilobular necrosis and fatty change of the liver

Question 13

Cigarette smoke

Answer 13

1) Laryngeal squamous cell carcinoma
2) Squamous cell carcinoma and small cell carcinoma of the lung
3) Renal cell carcinoma
4) Transitional cell carcinoma of the bladder
5) Pancreatic adenocarcinoma

Question 14

Arsenic

Answer 14

1) Squamous cell carcinoma of the skin

2) Angiosarcoma of the liver

Question 15

Naphthalene (aniline) dyes

Answer 15

Transitional cell cancer of the bladder

Question 16

Alkylating agents

Answer 16

Leukemia

Question 17

Psammoma bodies

Answer 17

1) Papillary adenocarcinoma of thyroid
2) Serous papillary cystadenocarcinoma of ovary
3) Meningioma
4) Malignant mesothelioma