Autonomic drugs

Question 1

Alpha-1 receptors

Answer 1

1) Gq

2) Vascular contraction, mydriasis, intestinal and bladder sphincter contraction

Question 2

Alpha-2 receptors

Answer 2

1) Gi

2) Decreased insulin secretion, decreased lipolysis and increased platelet aggregation

Question 3

Beta-1

Answer 3

1) Gs

2) Increased HR, contractility, increased renin, increased lipolysis

Question 4

Beta-2

Answer 4

1) Gs
2) Increased HR, contractility, increased lipolysis, increased insulin release, decreased uterine tone, ciliary muscle relaxation, increased aqueous humor

Question 5

Bethanechol

Answer 5

1) Cholinomimetic, resistance to AChE

2) Postoperative ileus, neurogenic ileus and urinary retention

Question 6

Carbachol

Answer 6

1) Cholinomimetic

2) Glaucoma

Question 7

Pilocarpine

Answer 7

1) Cholinomimetic
2) Sweat, tears, saliva
3) Glaucoma

Question 8

Edrophonium

Answer 8

1) Increases endogenous ACh

2) Diagnosis MG

Question 9

Donepezil

Answer 9

1) Increases endogenous ACh

2) Alzheimer’s

Question 10

Scopolamine

Answer 10

1) Anti-muscarinic

2) Motion sickness

Question 11

Oxybutynin

Answer 11

1) Anti-muscarinic

2) Reduces bladder spasm

Question 12

Glycopyrrolate

Answer 12

1) Anti-muscarinic
2) Post operatively used to reduce secretions
3) Drooling, peptic ulcer

Question 13

Isoproterenol

Answer 13

1) Beta-selective sympathomimetic

2) Torsades, bradyarrhythmias (can worsen ischemia)

Question 14

Dobutamine

Answer 14

1) Beta-1 selective sympathomimetic

2) Heart failure, stress test

Question 15

Phenylephrine

Answer 15

1) Alpha selective sympathomimetic

2) Decongestant

Question 16

Terbutaline

Answer 16

1) Beta-2 selective sympathomimetic

2) Reduces uterine contractions (premature labor)

Question 17

Ritodine

Answer 17

1) Beta-2 selective

2) Reduces premature uterine contractions

Question 18

Clonidine; alpha-methyldopa

Answer 18

1) Centrally acting alpha-2 agonists

2) Hypertension with renal disease

Question 19

Phentolamine

Answer 19

1) Reversible alpha-blocker

2) MAOI + tyramine crisis

Question 20

Mirtazapine

Answer 20

1) Alpha-2 blocker

2) Depression -> increases sleeping and appetite

Question 21

Timolol

Answer 21

Beta-blockers which can be used for glaucoma

Question 22

Metoprolol; esmolol

Answer 22

Beta-blockers which can be used for SVT’s

Question 23

B1-selective antagonists

Answer 23

*for pulmonary disease (A BEAM)
Acebutolol
Betaxolol
Esmolol
Atenolol
Metroprolol

Question 24

Non-selective beta-blockers

Answer 24

*Please Try Not Being Picky
Propanolol
Timolol
Nadolol
Pindolol

Question 25

Non-selective alpha/beta antagonists (vasodilatory)

Answer 25

1) Carvedilol

2) Labetalol