Classic labs/findings

Question 1

Anti-centromere antibodies

Answer 1

CREST

Question 2

Anti-histone antibodies

Answer 2

Drug-induced SLE -> hydralazine, INH, phenytoin, procainamide

Question 3

Anti-mitochondrial antibodies

Answer 3

Primary biliary cirrhosis -> female, cholestasis, portal HTN

Question 4

Anti-platelet antibodies

Answer 4

ITP

Question 5

Anti-topoisomerase antibodies

Answer 5

Diffuse scleroderma

Question 6

Boot-shaped heart on X-ray

Answer 6

Tetrology of Fallot, RVH

Question 7

Branching gram-positive rods with sulfur granules

Answer 7

Actinomyces israelli

Question 8

Brown tumor of bone

Answer 8

Hyperparathyroidism -> Osteitis fibrosa cystica

Question 9

Circular grouping of dark tumor surrounding pale neurofibrils

Answer 9

Homer-Wright rosettes -> neuroblastoma, medulloblastoma, retinoblastoma

Question 10

Decreased alpha-fetoprotein

Answer 10

Down syndrome or other chromosomal abnormality

Question 11

Desquamated epithelium casts in sputum

Answer 11

Curshmann’s spirals -> bronchial asthma -> whorled mucus plugs

Question 12

Disarrayed granulosa cells in eosinophilic fluid

Answer 12

Call-Exner bodies -> granulosa-theca cells tumor of the ovary

Question 13

Enlarged thyroid cells with ground-glass nuclei

Answer 13

Orphan Annie -> Papillary carcinoma of the thyroid

Question 14

Eosinophilic cytoplasmic inclusion in the liver cells

Answer 14

Mallory bodies -> alcoholic liver disease

Question 15

Eosinophilic cytoplasmic inclusion in the nerve cells

Answer 15

Lewy body

Question 16

Eosinophilic globule in the liver

Answer 16

Councilman body -> toxic or viral hepatitis -> yellow fever

Question 17

Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

Answer 17

Negri bodies of rabies

Question 18

Hair on end -> crew cut on X-ray

Answer 18

Sickle cell, Beta-thalassemia

Question 19

Granulomatous heart nodules

Answer 19

Aschoff bodies -> rheumatic heart disease

Question 20

Hexagonal, double-jointed, needle-like crystals in bronchial secretions

Answer 20

Bronchial asthma -> Charcot Leyden crystals -> eosinophilic granules

Question 21

Hypertension, hypokalemia, metabolic alkalosis

Answer 21

Conn’s syndrome

Question 22

Hypochromic, microcytic anemia

Answer 22

1) Iron deficiency anemia
2) Lead poisoning
3) Thalassemia

Question 23

Iron-containing nodules in alveolar septum

Answer 23

Ferruginous bodies -> asbestosis

Question 24

Large lysosomal vesicles in phagocytes, immunodeficiency

Answer 24

Chediak-Higashi -> no phagolysosome formation

Question 25

Onion skin periosteal reaction

Answer 25

Ewing’s sarcoma

Question 26

Rhomboid crystals, positively birefringent

Answer 26

Pseudogout -> calcium pyrophosphate dihydrate crystals

Question 27

Rib notching

Answer 27

Coarctation of aorta

Question 28

Silver-staining spherical aggregation of tau protein in neurons

Answer 28

Pick bodies -> progressive dementia, changes in personality

Question 29

Soap bubble in femur or tibia on x-ray

Answer 29

Giant cell tumor of bone -> benign

Question 30

Thyroid-like appearance of kidney

Answer 30

Chronic bacterial pyelonephritis

Question 31

Waxy casts with little urine flow

Answer 31

End-stage renal disease

Question 32

Smudges WBCs

Answer 32

CLL (B-cell)

Question 33

Wire loop glomerular capillary appearance on light microscopy

Answer 33

Lupus nephropathy