Psychiatric-Mental Health Flashcards
Suicide Risk Factors
- Older person who had recently lost a spouse (due to death or divorce)
- Plan involving gun or other lethal weapon
- Hx of attempted suicide and/or family hx of suicide
- Mental illness (depression, bipolar ds)
- Hx of sexual, emotional, and/or physical abuse
- Terminal illness, chronic illness, chronic pain
- Alcohol abuse, substance abuse
- Age 15-24 yrs or >60
- Significant loss (divorce, breakup w/ boyfriend/girlfriend, job loss, death of a loved one)
- Elderly males who recently lost a partner are at highest risk of suicide
Demographic subgroups
- American Indian and Alaska Native youth and middle-age persons have the highest rate of suicide
- African Americans have the lowest suicide rate
- Females make more attempts
- Males more likely to die by suicide
Acute Serotonin Syndrome (Serotonin Toxicity): Overview
- Occurs from high levels of serotonin accumulating in body d/t introduction of a new drug (drug interaction) and an ↑ in dose
- acute onset with rapid progression
- Hunter Toxicity Criteria Decision Rules/Criteria
Look for:
- dilated pupils (mydriasis)
- higher risk if combining 2 drugs that lboth both serotonin (e.g., SSRIs, MAOIs, TCAs, triptans, tryptophan)
If switching to another drug affecting serotonin, wait a minimum of 2 weeks
** Acute serotonin syndrome is a potentially life-threatening reaction → Refer to ED!
Acute Serotonin Syndrome (Serotonin Toxicity): Hunter Toxicity Criteria Decision Rules/Criteria
Pt must have taken a serotonergic agent and meet one of the following conditions:
- spontaneous clonus
- inducible clonus + agitation and diaphoresis
- ocular clonus + agitation or diaphoresis
- termor + hyperreflexcia
OR
- hypertonia + temperature >100.4º (38ºC) + ocular clonus or inducible clonus
Malignant Neuroleptic Syndrome: Overview
- Rare life-threatening idiopathic reaction from typical and atypical antipsychotics
- often seen w/ high-potency, first-gen antipsychotics (e.g., chlorpromazine, haloperidol)
- Mortality rate 10-20%
- can be seen in Parkinson’s disease (parkinsonism hyperpyrexia syndrome) d/t withdrawal of L-dopa or dopamine agonist therapy, dose reduction, or switching medications
- usually develops following initiation or a rapid ↑ in dose
S/Sx
- sudden onset of high fever
- muscular rigidity
- mental status changes
- dysautonomia (fluctuating BP)
- urinary incontinence
Look for hx of mental illness and prescription of antipsychotics
** Potentially life-threatening reaction → Refer to ED!
Psychiatric-Mental Health Evaluation
At-Risk Patients: The Baker Act
Allows 72 (3 days) of involuntary detention for evaluation and treatment of persons who are considered at very high risk for suicide and/or hurting others
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires
- Beck Depression Inventory-II
- Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5)
- Folstein Mini-Mental State Exam (MMSE)
- Geriatric Depression Scale (GDS)
- Generalized Anxiety Disorder 7-Item (GAD 7) Scale
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires - Best Depression Inventory-II
A multiple-choice self-report inventory for evaluating depression; based on the theory that negative cognitions about the self and world in general can cause depression
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires - DSM-5
The diagnostic manual for mental and emotional disorders created and used by the APA
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires - Folstein Mini-Mental State Exam (MMSE)
A questionnaire used to evaluate an individual for confusion and dementia (e.g., Alzheimer’s, stroke)
Testing tip: A question on the MMSE or MME will describe an action (such as asking a patient to spell world backward) and ask you to indicate the name of the tool that is being used
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires - GDS
A 30-item (yes/no response) questionnaire. Shorter version contains 15 items; used to assess depression in the elderly; self-assessment format
Psychiatric-Mental Health Evaluation: Common Mental Health Questionnaires - GAD-7
A 7-item screening tool for helping to identify patients w/ anxiety
- valid and efficient tool (89% sensitivity and 82% specificity)
- The higher the score, the higher the anxiety level
Points for Levels of Anxiety:
Mild anxiety (5)
Moderate anxiety (10)
Severe anxiety (≥15)
Folstein Mini-Mental State Exam Components
Cognitive Skill → Action Required
* Orientation → What ist he date today? (current day, month, year); Location? (name of the city, county, state)
- Immediate Recall (Recall 3 objects) → Instruct patient that that you will be testing their memory; say 3 unrelated words (pencil, apple, ball); ask pt to repeat words
- Attention and Calculation (Counting backward, Backward spelling) → Say “starting at 100, count backward and keep subtracting 7”; say “spell the word world backward”
- Writing and Copying (Writing a Sentence; copying a figure) → Give person one black piece of paper and ask them to write a sentence; draw intersecting pentagons; as pt to copy the pentagons
- Scoring → Max score is 30 correctly done
Score of <19 indicates impairment
Psychotropic Drugs: Atypical Antipsychotics
1. Examples
2. Adverse Effects
3. Monitor what?
- Olanzapine (Zyprexa)
- Risperidone (Risperdal)
- Quetiapine (Seroquel)
- Olanzapine (Zyprexa)
- Obesity
- DM2
- Obesity
- All can cause weight gain
- Check BMI
- Check weight Q3 months
- All can cause weight gain
Psychotropic Drugs: Typical Antipsychotics!
1. Examples
2. Adverse Effects
3. Monitor what?
- Haloperidol (Haldol
- Chlorpromazine
- Haloperidol (Haldol
- Elevates lipids/triglycerides
- Extrapyramidal effects
- Tardive dyskinesia
- QT prolongation
- Sudden death
- Malignant neuroleptic syndrome (rare)
- Elevates lipids/triglycerides
- Labs → Fasting blood glucose and lipids
BBW!! → Frail elderly are at higher risk of death from antipsychotics
- Look for signs of extrapyramidal sx: dystonia, parkinsonism, akathisia (inability to stay still) tardive dyskinesia
Psychotropic Drugs: Anticonvulsants
1. Examples
2. Adverse Effects
3. Monitor what?
- Lamotrigine (Lamictal)
- Carbamazepine (Tegretol)
- Valproate (Depakote)
- Lamotrigine (Lamictal)
- Stevens-Johnson syndrome (Lamictal)
- Advise pt to report rashes (Stevens-Johnson)
- some anticonvulsants are also used as a mood stabilizers for bipolar ds
- Monitor serum carbamazepine concentration
- check serum valproic acid concentration
- Advise pt to report rashes (Stevens-Johnson)
Psychotropic Drugs: SSRIs! →
1. Examples
2. Adverse Effects
3. Monitor what?
- First-line treatment for?
- Common SSRIs
- Sertraline (Zoloft)
- Paroxetine (Paxil)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
* SSRIs are also indicated for chronic anxiety disorders (social anxiety disorder, panic disorder)
- Sertraline (Zoloft)
- All SSRIs can cause sexual dysfunction
- Highest risk of erectile dysfunction (ED)
- elderly on multiple drugs, less risk of drug interactions
- All SSRIs can cause sexual dysfunction
- BBW!! → All SSRIs may cause suicidal ideation/plans (<24 yo)
- Do NOT discontinue Paxil abruptly; wean gradually
* Has a short half-life (compared w/ other SSRIs), and needs to be weaned; do NOT discontinue abruptly, will cause withdrawal sx
- BBW!! → All SSRIs may cause suicidal ideation/plans (<24 yo)
- Major depressoin, OCD
- GAD, panic ds, social anxiety ds
- Premenstrual dysphoric ds
- PTSD
- Major depressoin, OCD
- Fluoxetine (Prozac) → Longest half-life and first SSRI (useful for noncompliance)
- Paroxetine (Paxil) → shortest half-life
* Common SE: erectile dysfunction → * Bupropion is used off-label for antidepressant-induced sexual dysfunction caused by SSRIs
- Fluoxetine (Prozac) → Longest half-life and first SSRI (useful for noncompliance)
- Citalopram (Celexa) → Has fewer drug interactions compared w/ other SSRIs
- Other SSRIs: Sertraline (Zoloft), fluvoxamine (Luvox)
SSRIs
6. Side Effects
7. Contraindications
- Loss of libido, ED, anorexia, insomnia
- avoid w/ anorexic pts and undernourished elderly (depresses appetite more)
- Taper SSRIs over 2-4 weeks prior to discontinuation
- Loss of libido, ED, anorexia, insomnia
Paroxetine (Paxil): common SE: ED
- most likely to cause sx and may need to be discontinued for a period of 3-4 weeks or longer (slower wean)
Fluoxetine is least likely to cause discontinuation syndrome because of its long elimination half-life; can be tapered over 1-2 weeks
- Abrupt discontinuation may precipitate dysphoria, fatigue, chills, myalgias, headache, dizziness, gastrointestinal distress
- discontinuation syndrome occurs in 20-30%
- Avoid within 14 days of taking an MAOI (serotonin syndrome)
- Can induce mania w/ bipolar pts
- Avoid within 14 days of taking an MAOI (serotonin syndrome)
Psychotropic Drugs: Atypical Antidepressants
1. Examples
2. Adverse Effects
3. Monitor what?
- Bupropion (Wellbutrin)
- Bupropion (Zyban)
- Bupropion (Wellbutrin)
- Bupropion is used off-label for antidepressant-induced sexual dysfunction caused by SSRIs
- also used to treat major depression, seasonal affective disorder, and smoking cessation
- increases risk of seizures; avoid if pt at higher risk of seizures (during abrupt discontinuation of ethanol, benzodiazepines)
- Seizures
- Contraindicated w/ seizures ds, anorexia, or bulimia
- For smoking cessation
- Contraindicated w/ seizures ds, anorexia, or bulimia
Psychotropic Drugs: SNRIs
1. Examples
2. Adverse Effects
3. Monitor what?
4. Mechanism of Action
5. Indications
- Venlafaxine (Effexor)
- Duloxetine (Cymbalta)
- Desvenlafaxine (Pristiq)
- Venlafaxine (Effexor)
- Can precipitate acute narrow-angle glaucoma
- Bioavailability ↓ in 33% in smokers
- Can precipitate acute narrow-angle glaucoma
- Avoid w/ uncontrolled narrow-angle glaucoma
- Do not take 5 days before or 14 days after MAOI, linezolid, selegiline, IV methylene blue
- Avoid w/ uncontrolled narrow-angle glaucoma
- ↑ available serotonin and norepinephrine in brain
Duloxetine (Cymbalta) → can tx GAD, fibromyalgia, depression, and diabetic peripheral neuropathy; smoking ↓ bioavailability by 33%
* An SNRI used to for depression, chronic anxiety, and management of diabetic peripheral neuropathy
Psychotropic Drugs: TCAs
1. Examples
2. Adverse Effects
3. Monitor what?
4. Indications
5. Avoid in what?
- Amitriptyline (Elavil)
- Nortriptyline (Pamelor)
- Doxepin (Sinequan)
- imipramine (Tofranil)
- Amitriptyline (Elavil)
- Anticholinergic effects
- Category X
- Anticholinergic effects
- Do not combine w/ SSRIs, or MAOIs, as they will ↑ risk of serotonin syndrome
- NOT considered first-line tx for depression
- Other uses: Postherpetic neuralgia (chronic pain), urinary incontinence
- NOT considered first-line tx for depression
- Avoid if pt at high risk for suicide because they may hoard pills and overdose (suicide attempt)
- Overdose causes fatal cardiac (ventricular arrhythmia) and neuro effects (seizures)
** TCAs used for herpetic neuralgia, migraine headache prophylaxis (NOT acute treatment)
Psychotropic Drugs: Lithium
1. Examples
2. Adverse Effects
3. Monitor what?
- Lithium carbonate (Eskalith)
- Contrainidcated of sodium depletion, dehydration, significant renal or cardiovascular ds
- Used for bipolar ds
- “Ebstein’s anomaly” is a congenital heart defect caused by lithium
- Check serum trough level (12 hrs after last dose)
- Used for bipolar ds
Monoamine Oxidase Inhibitors (MAOIs)
1. Examples
2. Indications
3. Contraindications
4. What foods should you avoid?
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
- Phenelzine (Nardil)
- RArely used d/t serious food (high tyramine content) and drug interactions
- Do NOT combine w/ SSRIs, TCAs, monoamine oxidase B (MAO-B → selegiline [Eldepryl]), serotonin receptor agonists (e.g., sumatriptan [Imitrex], zolmitriptan [Zomig])
- RArely used d/t serious food (high tyramine content) and drug interactions
- Do NOT combine MAOI w/ SSRI or TCA
- Wait at least 2 weeks before initiating SSRI or TCA (high risk of serotonin syndrome)
- Do NOT combine MAOI w/ SSRI or TCA
- High-Tyramine Foods and MAOIs
- The combination can cause tyramine pressor response (elevates BP, risk of stroke)
- AVOID combining w/ fermented foods such as beer, Chianti wine, some aged cheeses, fava beans
- High-tyramine foods can also cause migraine headache in susceptible persons
Benzodiazepines (Tranquilizers)
1. Indications & Considerations
2. Examples
- ultra-short acting
- medium-acting
- long-acting
- anxiety ds, panic =ds, and insomnia
- Diazepam (Valium) is also used for severe alcohol withdrawal and seizures
- Do NOT abruptly discontinue d/t ↑ risk of seizures; wean slowly
- anxiety ds, panic =ds, and insomnia
- Ultra-short acting: Midazolam IV only (Versed); triazolam (Halcion)
- Medium-acting: Alprazolam (Xanax), lorazepam (Ativan)
- Long-acting: Diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), and clonazepam (Klonopin)
- Ultra-short acting: Midazolam IV only (Versed); triazolam (Halcion)
Major and Minor Depression
1. Definition/Etiology
2. Symptoms
- Aka unipolar depression (vs. bipolar depression)
- minor depression → milder form
- criteria of s/sx are same as major depression except there are fewer sx (at least 2 but <5).
- attributed to dysfunction of neurotransmitters serotonin and norepinephrine
- strong genetic component - Mood: depressed most of the time; may become tearful
- Anhedonia: diminished interest or pleasure in all or most activities
- Energy: fatigues or loss of energy
- Sleep: Insomnia or hypersomnia
- Guilt: feelings of worthlessness and inappropriate guilt
- Concentration: diminished concentration and difficulty making decisions
- Suicide: recurrent/obsessive thoughts of death and suicidal ideation
- Weight: weight loss (>5% of body weight) or weight gain
- Agitation: psychomotor agitation or retardation
- Mood: depressed most of the time; may become tearful
Major and Minor Depression
3. Immediate Goals
4. Differential Diagnoses
5. Screening Tools
- Assess for suicidal and/or homicidal Ideation or Plan
- If pt is considered to be a real and present threat of harm to self or others
- Refer to psychiatric hospital; pt must be driven by a family or friend
- If non available, call 911 for police; the police can “Baker Act” the patient - Rule our organic causes
- hypothyroidism
- anemia
- autoimmune ds
- vitamin B12 deficiency
- Rule our organic causes
- Beck Depression Inventory: Contains 21 Items
- Beck Depression Inventory for Primary Care (99% specificity): contains 7 items
- 2-Item Question → Ask the following 2 questions; if yes to either question (or both), positive finding:
* During the past month, have you felt down, depressed, or hopeless?
* During the past month, have you felt little interest or pleasure doing things?
- Beck Depression Inventory: Contains 21 Items
Major and Minor Depression
6. Labs
7. Treatment Plan
- CBC
- chemistry profile
- TSH
- folate
- vit B12
- UA
** Rule out organic causes; toxicology screen to r/o illicit drug use if a risk
- CBC
- R/O ds such as anemia, diabetes, hypothyroid (TSH/thyroid panel), chemistry panel (low K for ADdison’s disease) and vit B12 anemia
- Refer for psychotherapy; CBT can reduce sx (comparable to an antidepressant med) and is usually effective → if necessary, refer to psychiatrist or PMHNP; if psychotic → Refer to ED!
- Psychotherapy + antidepressants work better together than alone
- R/O ds such as anemia, diabetes, hypothyroid (TSH/thyroid panel), chemistry panel (low K for ADdison’s disease) and vit B12 anemia
- Pt starting to recover from depression may commit suicide (from ↑ in psychic energy); monitor closely!
- If potentially suicidal, be careful when refilling or prescribing certain meds that may be fatal if pt overdose (e.g., benzos, hypnotics, narcotics, amphetamines, TCAs); give smallest amount and lowest dose possible with close follow-up!
Major and Minor Depression
8. First-line Meds
9. Other antidepressants
10. FDA BBW!
- SSRIs
- Tell pts that antidepressants effect may take 4-8 weeks (up to 12 wks) to manifest
- also first line therapy for elderly pts because of fewer side effects
* Initiation of meds for elderly and pts diagnosed w/ renal or hepatic ds should begin at low dose and increased slowly and gradually as tolerate
* After initiation, follow up in 2 weeks to check for compliance and SE
* Continue SSRI therapy for at least 4-9 months after sx have resolved (usually on first episode); frequent relapse means pt may need lifetime treatment
- SSRIs
- TCAs (amitriptyline [Elavil], nortriptyline [Pamelor])
- Prefer bedtime dose d/t sedation
- other sues: postherpetic neuralgia, chronic pain, stress urinary incontinence
- Avoid w/ suicidal pts because they may hoard pills and take an overdose (causes fatal arrhythmias)
- TCAs (amitriptyline [Elavil], nortriptyline [Pamelor])
- ↑ risk of death in elderly (with dementia) on antipsychotic drugs such as haloperidol (Haldol) and chlorpromazine (Thorazine)
SSRIs: Special Considerations
1. FDA BBW in children, adolescents, & young adults
2. Elderly pts
3. Pts w/ sexual dysfunction caused by SSRI
4. Depressed pts who want to quit smoking
5. Depressed pt w/ peripheral neuropathy
6. Depressed pt w/ postherpetic neuralgia & chronic pain
7. Depressed pt w/ stress urinary incontinence
- ↑ risk of suicidal thinking and behavior in children, adolescents, sand young adults
- risk of suicidality is ↑ in young adults 18-24 yrs during initial treatment (first 1-2 months) - Consider using citalopram (Celexa) and escitalopram (Lexapro)
- fewer drug interactions than other SSRIs
- may prolong QT interval
- Consider using citalopram (Celexa) and escitalopram (Lexapro)
- Consider adding bupropion (Wellbutrin)
- another option is switch to an ANRI or atypical antidepressant
- Consider adding bupropion (Wellbutrin)
- Consider bupropion (Zyban)
- Can be combined w/ nicotine-avoidance products (e.g., patches, gum)
- Consider bupropion (Zyban)
- Consider duloxetine (Cymbalta)
- also indicated for neuropathic pain - Consider TCAs
- Consider TCAs
Antipsychotics: Adverse Effects
- pill rolling
- shuffling gait
- bradykinesia
► caused by chronic use of antipsychotics - Extrapyramidal symptoms (EPS):
- Akinesia
- Akathisia
- Bradykinesia
- Tardive dyskinesia
- can lead to ↑ risk of obesity, DM2, HLD, metabolic syndrome, and hypothyroidism
- Both classic and new generation have strong anticholinergic effects
Akinesia
inability to initiate movement
Akathisia
A strong inner feeling to move, unable to stay still
Bradykinesia
slowness in movement when initiating activities or actions that require successive steps such as buttoning a shirt