Neuro Flashcards

1
Q

Dangerous Headaches: Warning s/s

A
  • Thunderclap headache (very severe headaches hat reaches max intensity in 1 min or less)
  • “Worst headache of my life”
  • First onset of headache at ≥ 50 yo
  • Sudden onset of headache after coughing, exertion,s training, or sex (exertional headache)
  • Sudden change in LOC
  • Focal neuro sign s(e.g., unequal pupil size, hemiparesis, loss of function, poor gag reflex, difficulty swallowing, aphasia, sudden vision loss, vidual field defect)
  • Head w/ papilledema (↑ ICP 2º to those listed here)
  • “Worse-case” scenario of headaches r/o includes the following:
    ► Subarachnoid hemorrhage 9SAH) or acute subdural hemorrhage
    ► Leaking aneurysm or arteriovenous malformation (AVM)
    ► Bacterial meningitis
    ► Increase ICP
    ► Brain abscess
    ► Brain tumor
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2
Q

Subarachnoid Hemorrhage: General Overview

A
  • Sudden and rapid onset of severe headache
  • described as “the worse headache of my life”
  • accompanied by N/V, neck pain or stiffness (+Brudzinski and/or Kernig signs)
  • Photophobia
  • visual changes (diplopia, visual loss)
  • Rapid ↓ LOC
  • Headache can be localized or nonlocalized in occipital area/neck
  • may have seizures during acute phase
  • VS: ↑ BP, ↑ temp, ↑ HR

Depending on source of bleed → focal neuro signs or no signs
- Usually caused by ruptured cerebral aneurysm or AVM

“Sentinel headache” → sudden intense headache
- can precede a spontaneous SAH by days to weeks
- An unenhanced CT scan can detect an SAH in approx 95% of pt within first 24 hours
- ~22% of patients die on same day
- MEDICAL EMERGENCY! CALL 911!!

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3
Q

Acute Bacterial Meningitis (In adults): General Overview

A
  • Neonates, infants, and elderly are at ↑ risk
  • Community-acquired is most commonly d/t Streptococcus pneumoniae (50%) and Neisseria meningitides (30%)

S/S
- Acute onset of high fever
- severe headache
- stuff neck (nuchal rigidity)
- meningismus w/ AMS

  • Classic purple petechial rashes appear
  • accompanied by N/V, photophobia
  • Rapid worsening of sx → lethargy, confusion, and coma

If not treated, FATAL
Bacterial Meningitis is a MEDICAL EMERGENCY! Call 911!

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4
Q

Giant Cell Arteritis (Temporal Arteritis): General Overview

A
  • Acute onset of headache, located on one temple of an older pt (avg 70 years)
  • May c/o excruciating burning pain over affected temporal artery instead of headache
  • affected temple has indurated, reddened, and cord-like temporal artery (tender and warm to touch) accompanied w/ scalp tenderness
  • Abrupt onset of visual disturbances and/or transient blindness of affected eye (amaurosis fugax)
  • may c/o jaw pain or jaw claudication (caused by artery obstruction)
  • Marked ↑ ESR and CRP
  • Hx of polymyalgia rheumatica (PMR) are at very high risk of developing this (30%)
  • Headache may be accompanied by symptoms of PMR (fever, pain on shoulders/hips [polymyalgia], anorexia, weight loss)

***If left untreated → BILATERAL BLINDNESS!

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5
Q

Acute Stroke (Cerebrovascular Accident): General Overview

A
  • Either Embolic (87%) or hemorrhagic (13%)

RF for embolization:
- afib, prolonged immobilization
- presents w/ acute onset of stuttering/speech disturbance
- on-sided facial weakness
- one-sided weakness of arms/legs (hemiparesis)

Hemorrhagic:
- poorly controlled HTN
- present w/ abrupt onset of a severe headache
- N/V
- nuchal rigidity (subarachnoid bleed)

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6
Q

Chronic Subdural Hematoma: General Overview

A
  • Bleeding b/w dura and subarachnoid membranes of brain
  • presents gradually
  • sx may not show until a few weeks after injury
  • hx of head trauma (falls, accidents)
  • presents w/ hx of headaches and gradual cognitive impairment (apathy, somnolence, confusion)
  • more common in alcoholics, elderly, and those on anticoagulation or aspirin therapy
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7
Q

Multiple Sclerosis: General Overview

A
  • Adult female c/o episodic visual loss or diplopia (double vision)
  • problems w/ balance and walking
  • numbness and paresthesia on one side of face
  • accompanied by urinary incontinence (75%) and/or bowel dysfunction (50%)
  • reports that when bending neck forward/flexion, an electric shock-like sensation runs down the back (Lhermitte sign)
  • Not emergent, but recognization of s/s important!
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8
Q

Neurological Testing:
1. Includes what components?
2. What mental status exams can be conducted for pts?

A
    • mental status
      - cranial nerves (CN)
      - motor, reflex, and sensory exam
    • Folstein Min-Mental State Exam (MMSE)
      - CN exam
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9
Q

Mini-Mental State Exam: Components

A
  • Orientation (Name, age, address, job, time/date/season)
  • Registration (Recite 3 unrelated words; distract pt for 5 mins, then ask pt to repeat works)
  • Attention and calculation
  • Spell world backward or indicate serial 7s (subtract 7 starting at 100)
  • Language
  • While speaking to pt, look for aphasia (impairment in language → difficulty speaking)
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10
Q

Cerebellar Testing
1. Definition
2. Types

A
  1. Cerebellum coordinates unconscious regulation of balance, muscle tone, and coordination of voluntary movements
    • Gait
      - Tandem gait
      - Rapid alternative movements
      - Heel-to-shin testing
      - Finger-to-nose and finger-to-finger test

** Clinical findings that are highly suggestive of damage to the cerebellum are ataxia, disequilibrium, as manifested by a wide-based gait, and muscular hypotonia

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11
Q

Cerebellar Testing: Gait
1. Definition
2. What indicates positive?

A
  1. Tell pt to walk to other side of room and back. If using walking aid (e.g., cane, walker), test pt w/ walking aid. Observe gait–is pt shuffling, scissoring, waddling, or swinging?
  2. POSITIVE: If acute cerebellar ataxia, pt will have a wide-based staggering gait
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12
Q

Cerebellar Testing: Tandem gait
1. Definition
2. What indicates positive?

A
  1. Tell pt to walk a straight line in normal gait, then instruct pt to walk in straight line w/ one foot in front of the other
  2. POSITIVE: if pt is unable to perform tandem walking, loses balance, and falls
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13
Q

Cerebellar Testing: Rapid alternating movements
1. Definition
2. What indicates positive?

A
  1. Pt to place hands on top of each thigh and move them (alternating between supination and pronation) as fast as possible
  2. POSITIVE: Pt unable to problems w/ rapid alternating movements (dysdiadochokinesia)
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14
Q

Cerebellar Testing: Heel-to-shin testing
1. Definition
2. What indicates positive?

A
  1. Pt in supine position w/ extended legs. Tell pt to place L heel on R knee and move it down the shin (repeat w/ R heel on L knee)
  2. POSITIVE: Unable to keep their foot on shin
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15
Q

Cerebellar Testing: Finger-to-nose and finger-to-finger test
1. Definition
2. What indicates positive?

A
  1. Pt to fully extend arm, then touch their nose of ask them to touch their nose, then extend arms and touch your finger
  2. POSITIVE: Unable or misses touching nose and/or finger to nose (dysmetria)
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16
Q

Proprioception: Romberg Test
1. Definition
2. What indicates positive?

A
  1. Pt to stand w/ arms/hands straight on each side and feet together w/ eyes open and observe. Next, instruct pt to close both eyes while standing in same position and observe
  2. POSITIVE: Positive if pt sways excessively, falls down, or has to keep feet wide apart to maintain balance. If abnormal → neuropathy or posterior column (of spine) disease
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17
Q

Cranial nerve Testing:

A

OOOTTAFAGVSH - “On Old Olympus Towering Tops, A Fin And German Viewed Some Hops”
CN I - Olfactory
CN II - Optic
CN III - Oculomotor
CN IV - Trochlear
CN V - Trigeminal
CN VI - Abducens
CN VII - Facial
CN VIII - Acoustic
CN IX - Glossopharyngeal
CN X - Vagus
CN XI - Spinal Accessory
CN XII - Hypoglossal

SSMMBMBSBBMM - “Some Say Marry Money But My Brother Say Big Boobs Matter Most”

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18
Q

CN I

A

Olfactory
- Use familiar cent (e.g., coffee, peppermint)
- Block one nostril at a time

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19
Q

CN II

A

Optic
- Visual field testing: Pt stands ~2 feet in front of examiner and covers their left (or right) eye. stretch arm so that it is in peripheral visual field and ask pt if they see 1, 2, or 3 fingers (all four quadrants)
- Stare straight ahead at about the same level as pt (examiner serves as the “control”)

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20
Q

CN III

A

Oculomotor
- CN III, CN IV, and CN VI are usually tested together; they control EOM
- First, look for ptosis
- Stand ~2 feet in front of pt as they fixate gaze on fingers of examiner’s hand
- Instruct pt to “follow my fingers” while observing for nystagmus (horizontal quick movements of eyes in one direction, alternates w/ slower movements of eyes i opposite direction; test pupillary function

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21
Q

CN IV

A

Trochlear
- CN III, CN IV, and CN VI are usually tested together; they control EOM

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22
Q

CN V

A

Trigeminal
- Provides sensory nerves to face
- Test sensation by lightly touching forehead are, cheek, and chin
- Trigeminal nerve has 3 branches: the ophthalmic (V1), cheek (V2), and jaw area (V3)
- Tell pt to close eyes when testing; ask if they feel sensation

** Herpes zoster infection (shingles) of CN V (5) ophthalmic branch → corneal blindness
*** Rash on tip of nose and temple area: RULE OUT shingles infection of trigeminal nerve involving the ophthalmic branch (V1)

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23
Q

CN VI

A

Abducens
- CN III, CN IV, and CN VI are usually tested together; they control EOM

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24
Q

CN VII

A

Facial
- Controls facial muscles that enable facial expression
- Tell pt to close eyelids tightly try to open eye lids manually
- Tell pt to look up and wrinkle forehead, then tell pt to smile

  • Look for asymmetry and muscle atrophy
  • Bell’s palsy is d/t inflammation of facial nerve (motor portion)
    This affected side of face will not move and eyelid may not be fully close
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25
Q

CN VIII

A

Acoustic
- Hearing exam can be done by rubbing pt’s hair in front of ear
- Alternative: hold hand up as a sound screen then whisper a few numbers and ask pt if they heard the words

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26
Q

CN IX

A

Glossopharyngeal
- Both CN IX and X → control palate; usually tested together
- tell pt to open mouth, then yawn
- Observe for asymmetry; uvula should be midline
- Gag reflex can be tested by using tongue blade and lightly touching back of throat
- assess voice clarity (r/o dysarthria)

  • Innervates movement of soft palate (ask pt to yawn or say “aah” to check voice clarity)
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27
Q

CN X

A

Vagus
- Both CN IX and X → control palate; usually tested together

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28
Q

CN XI

A

Spinal Accessory
- Controls shoulder shrug and head rotation
- Tell pt to shrug both shoulders; should be same level
- Then pt rotate head to left; place hand on pt’s left cheek and instruct to push against it
- tell pt to turn head to R side, then follow same procedure
- Check sternocleidomastoid muscle for atrophy or asymmetry

** The number reminds you of shoulders shrugging together

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29
Q

CN XII

A

Hypoglossal
- Controls tongue movement
- Pt to stick out their tongue and move it from side to side
- Look for atrophy and asymmetry

** Innervates tongue (midline, no atrophy)

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30
Q

Sensory System
1. Definition
2. Sensory tests

A
  1. Tell pt to close their eyes for tests
    • Vibration sense
      - Sharp-dull touch
      - Temperature
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31
Q

Sensory System: Vibration sense
1. Definition
2. Positive

A
  1. Use 128-Hz tuning fork and tap lightly
    - Then, place one end into distal joint of each thumb
    - Pt should have eyes closed
    - For testing feet, place tuning fork on tips of toes and several areas on sole of feet
    - Go back and forth to compare one foot w/ the other
    - Check for numbness or ↓ vibration sense
    Important test of assessing severity of diabetic peripheral neuropathy
  2. POSITIVE: if pt does not feel anything or have ↓ sensation
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32
Q

Sensory System: Sharp-dull touch
1. Definition
2. Positive

A
  1. Use sharp end of safety pin or toothpick for sharp touch testing
    - For dull sensation → head to safety pin or eraser end of a pencil
  2. POSITIVE: Pt unable to discriminate sharp from dull sensation or sense vibration; vibration sense is often the ealier to be affected in ds such as peripheral neuropathy (polyneuropathy), which can be result of diabetes and vit B12 deficiency anemia
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33
Q

Sensory System: Temperature

A

Test ability to differentiate hot or cold

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34
Q

Stereognosis

A
  • Ability to recognize familiar object through sense of touch only
  • Place a familiar object (e.g., coin, key, pen) on pt’s palm and tell pt to identify the object w/ eyes closed
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35
Q

Graphesthesia

A

Ability to Identify figures “Written” on skin
- “Write” a large letter or number on pt’s palms using fingers (pt’s eyes are closed)

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36
Q

Motor Exam: Extremities + Positive findings
- UE & LE
- Hands & Feet
- Pronator drift tests

A

UE: Pt to raise both arms in front them, then pronate and supinate. Tell pt to bend and extend forearms, then push against resistance provided by examiner

Hands: Perform full ROM w/ hands & fingers, w/ and w/out resistance (by examiner); dominant hand will be slightly larger d/t more muscle development

LE: while supine, tell pt to flex each hip, then raise each leg separately while examiner provides resistance; compare legs

Feet: Perform full ROM on toes and ankles; examiner provides resistance

Pronator drift test: Pt stretch out arms w/ palms facing up, w/ eyes open. Tell pt to close eyes. wait for 20-30 seconds. Then tap arms briskly downward. if POSITIVE, one arm goes downward or drifts

POSITIVE:
- In upper motor neuro diseases (stroke, amyotrophic lateral sclerosis [ALS], polio)
- In lower motor neuro lesions (neuropathy, polio, nerve root compression, radiculopathy), look for muscle weakness, muscle wasting/atrophy, and fasciculations
- Gross exam (legs) and fine motor movements (hands); test walking, using hands for manipulation/pincer grasp, jumping, and so forth

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37
Q

Reflexes

A
  • Both sides should be compared w/ each other and should be equal
  • 31 pairs of spinal nerve roots, named for their associated vertebral body
  • Each pair exists at corresponding level, innervating distinct dermatomal distributions
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38
Q

Grading Reflexes

A

0 - No response
1+ - Low response
2+ - Normal or average response
3+ - Brisker than average response
4+ - Very brisk response (sustained clonus)

39
Q

Reflex Testing
- Types
- Instructions
- Positive findings?

A
  • Quadriceps reflex (knee-jerk response): Reflex centered at L2-L4.
    Directions: Tap patellar tendon briskly on each side
  • Achilles reflex (ankle-jerk response): reflex center at L5-S2 (tibial nerve)
    Directions: With pt’s leg dangling off exam table, hold foot in slight dorsiflexion and briskly tap Achilles tendon.
  • Weak to no response w/ peripheral neuropathy (diabetes, B12 deficiency anemia)
  • Plantar reflex (Babinski’s sign): Reflex center L4-S2
    Directions: stroke plantar surface of foot on lateral border from heel toward big toe (plantar flexion) is normal response.
  • Babinski’s sign if positive if toes spread like fan
    POSITIVE: Adults should have a NEGATIVE Babinski’s sign. For young infants, Babinski’s sign is considered a normal finding
40
Q

Deep Tendon Reflexes: what spinal cord segment does the following reflect:
1. Biceps
2. Triceps
3. Patellar (knee jerk)
4. Achilles (ankle jerk)

A
  1. C5, C6
  2. C7, C8
  3. L3, L4
  4. S1, S2
41
Q

Neurologic Maneuvers
1. Definition
2. Examples

A
  1. These tests are used to assess for meningeal irritation (meningismus). All are done w/ pt in supine position. In gen, there are more sensitive tests in children compared w/ adults
    • Kernig’s sign
      - Brudzinski’s sign
      - Nuchal Regidity
42
Q

Neurologic Maneuvers: Kernig’s sign

A

Pt should be supine
- Flex pt’s hip one at at ime, then attempt to straighten leg while keeping hip flexed at 90º

POSTIVE: Resistance to leg straightening d/t painful hamstrings (d/t inflammation on lumbar nerve roots) and/or complaints of back pain

43
Q

Neurologic Maneuvers: Brudzinski’s sign

A

Pt supine
- Passively flex/bend pt’s neck toward chest

POSITIVE: Pt reflexively flexes hips and knee to relieve pressure and pain (d/t inflammation of lumbar nerve roots)

44
Q

Neurologic Maneuvers: Nuchal Rigidity

A

Pt supine
- Tell pt to touch chest w/ chin.

POSITIVE: Inability to touch chest 2º to pain

45
Q

Acute Mild Traumatic Brain Injury in Adults
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications/Indications for Hospitalization

A

AKA Concussion
1. - Mild TBI = GCS 12-15 (measured 30 min after injury)
- Most pts are males (2:1)
- usually result of acceleration/deceleration forces on brain tissue

Common causes:
- MVA (20-45%)
- Falls (30-38%)
- Occupational accidents (10%)
- Recreational accidents (10%)
- Assaults (5-17%)

Sports w/ highest TBI:
- American football
- Ice hockey
- Soccer
- Boxing
- Rugby
- Common war-time injury for soldiers who participated in combat

    • Early sx: confusion
      - headache
      - dizziness/vertigo
      - poor balance
      - nausea and vomiting
      - most DO NOT lose consciousness
      - Antegrade and retrograde amnesia are common after injury
  1. Clinical; ask pt about details of accident, such as events leading up to injury, during episode, and events following concussion
    - Check med hx; inquire if on anticoagulation, chronic acetylsalicylic acid (ASA), or NSAIDs → higher risk of brain hemorrhage
    • Evaluate mental status, including short-term memory and attention space
      - Perform neuro assess and CN exam
      - Pay attention to vision (CN II), pupil exam, extraocular movements (CN III, IV, VI), facial movements (CN V)
      - Refer to ED if suspect head trauma → needs CT scan of head (without contrast)
  2. Indications for hospital admission:
    - GCS <15
    - Seizures or other neuro deficit(s)
    - Recurrent vomiting
    - Abnormal head CT (e.g., midline shift, hemorrhage, ischemia, mass effect)
46
Q

Multiple Sclerosis (MS)
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
  1. Autoimmune ds → antibodies attach myelin sheath → demyelination
    - Peak incidence: 15-45 years
    - More common in women (2-3:1), Caucasians
    - MS tends to affect optic nerves (CN II), spinal cord, brainstem, cerebellum, and white matter

FOUR Subtypes:
- Relapsing-remitting MS (90%)
- Primary progressive MS (10%)
- Secondary progressive MS
- Clinically isolated syndrome (~60% develop MS)

    • Adolescent to adult female
      - episodes of visual loss
      - diplopia (double vision)
      - Nystagmus
      - Vertigo
      - Problems w/ balance and walking
      - foot drop
      - numbness & paresthesia on one side of face
      - Bowel dysfunction (50%)
      - and/or urinary incontinence (75%)
      - When bending neck forward/flexion, an electric shock-like sensation runs down the back (Lhermitte sign)
  1. Diagnostic: MRI of brain and spinal cord
  2. Refer to neurologist for management
47
Q

Lhermitte sign

A

When bending neck forward/flexion, an electric shock-like sensation runs down the back

48
Q

Acute Bacterial Meningitis in Adults
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A
  1. A serious, acute bacterial infection of the leptomeninges that cover brain and spinal cord
    - Common pathogens in adults: S. pneumoniae, N. meningitides, and Haemophilus influenzae (the latter two are Gram-)
    - Bacterial meningitis is a reportable disease (local health department)
    • Acute onset of high fever
      - severe headache
      - stuff neck (nuchal rigidity)
      - rapid changes in mental status and LOC
      - Up to 78% of pt have mental status change (confusion, lethargy, stupor)

Other sx:
- photophobia
- nausea/vomiting
- Some pt may not present w/ all 3 sx (triad of fever, nuchal rigidity and change in LOC); suspect spinal epidural abscess

    • If at risk for cerebral herniation → CT of head BEFORE LP
      - Risk Factors: Papilledema, focal neuro deficit, abnormal LOC, new-onset seizure (within 1 wk of presentation), hx of CNS disease (stroke, mass), or immunocompromised (HIV, immunosuppressive therapy, solid organ or bone marrow transplant)
      - LP (elevated opening pressure): CSF contains large # of WBC (↑ WBC; cloudy CSF) → DEFINITIVE diagnosis made from bacteria isolated from CSF, w/ presence of ↑ protein and ↓ glucose levels in CSF
      - De NOT delay antimicrobial therapy if LP delayed by imaging studies; obtain blood cultures and start empiric antibiotics ASAP!
      - LAB tests: CBC w/ diff, BMP/CMP, coagulation profile, platelet counts, and BC x2
      - Gram stain and culture and sensitivity (C&S) of CSF fluid and blood are needed (before abx initiated)
    • Adults: 3rd-gen cephalosporin IV + chloramphenicol IV
      - >50 yo: Amoxicillin IV + 3rd gen cephalosporin IV
      - Prophylaxis of close contacts w/ rifampin PO or ceftriaxone IM
      - Immunization w/ pneumococcal vaccination shown to ↓ incidence
    • Pt who recover usually have permanent neurologic sequelae
      - Old pts have a higher mortality rate d/t presence of comorbid conditions
49
Q

Migraines Headaches (w/ or w/out Aura)
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
    • Migraine w/ aura → precedes onset of migraine headache may present as scotomas (blind spots on visual field) or flashings lights
      - Women with positive family hx at higher risk (3:1)
      - In children, migraine can present as abdominal pain
    • Adult woman c/o gradual onset of throbbing headache behind one eye
      - gradually worsens over several hours
      - photophobia and/or phonophobia
      - Frequently accompanied by nausea/vomiting (can be severe)
      - can last 3-72 hours
      - may become bilateral if not treated
      (see other cards for other classic signs/symptoms)
  1. Neuro exam normal
    - Clinical diagnosis
    • Rest in quiet and darkened room w/ ice pack to forehead
      - Nausea: drink ginger ale or cola; chew dry toast or saltine crackers
      - avoid heavy, fatty meals
      - Avoid precipitating foods or activities such as:
      - Monosodium glutamate (MSG) in Chinese foods; chocolate; nitrates/nitrates found in hot dogs; luncheon meat, and sausage + red wine, beer, caffeine; + sleep changes, stress, barometric weather changes
      - avoid odor triggers such as tobacco smoke, perfumes, and strong odors
      - Avoid visual triggers such as strobe lights, sunlight, glares
      - Avoid emotional or psychic stress

(see other cards for abortive vs prophylactic treatments)

50
Q

Headaches: Migraine without aura
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
    • Throbbing pain behind one eyes
      - Photophobia
      - Phonophobia
      - Nausea/vomiting
  1. Adult females
    • Red wine
      - MSG
      - Aspartame
      - Mensturation
      - Stress
51
Q

Headaches: Migraine with aura
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
    • Preceding symptoms + scotoma, scintillating lights, halos
  1. Adult females
  2. Foods high in tyrosine
52
Q

Headaches: Trigeminal neuralgia (CN V)
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
  1. Intense and very brief; sharp, stabbing pain, one cheek (second branch CN V)
  2. Older adults and elderly
    • Cold food
      - Cold air
      - Talking
      - Touch
      - Chewing
53
Q

Headaches: Cluster
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
  1. Severe “ice-pick” piercing pain behind one eye and temple
    - with tearing
    - rhinorrhea
    - ptosis
    - miosis on one side (Horner’s syndrome)
  2. Middle-aged males
  3. Occurs same time daily in clusters for weeks to months
54
Q

Headaches: Giant cell arteritis (temporal arteritis)
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
    • Unilateral pain
      - temporal area w/ scalp tenderness
      - skin over artery is indurated, tender, warm, and reddened
      - amaurosis fugax (temporary blindness) may occur
  1. Older adults and elderly
    • MEDICAL URGENCY! Can cause blindness if not treated
      - Polymyalgia rheumatica common in these pts
55
Q

Headaches: Muscle tension
1. Symptoms
2. At-Risk Patients
3. Aggravating Factors

A
    • Bilateral “band-like” pain
      - continuous dull pain
      - may last for days
      - may be accompanied by spasm of trapezius muscles
  1. Adults
  2. Stress

** With exception of muscle tension headaches (bilateral), ALL of the headaches seen on exam (and notes) are unilaterals

56
Q

Headaches: Abortive Treatments
- First-line therapy
- General overview

A

First-line: 5-HT-1 agonists: Sumatriptan (Imitrex)

  • RULE OUT CVD. Do not use (or mix) triptans or ergots if hx or signs of ischemic heart disease (MI, angina), CVA, TIAs, uncontrolled HTN, or hemiplegic migraine
  • Warn pt of possible flushing, tingling, chest/neck/sinus/jaw discomfort
  • Supervise first dose esp if pt has CVD (e.g., diabetes, obese, males >40 years, high lipids); give first dose in office (theoretical risk of an acute MI)
  • Consider EKG monitoring if pt is at high risk for heart ds
  • ↑ risk of serotonin syndrome if combined w/ SSRIs or SNRIs (duloxetine [Cymbalta], venlafaxine [Effexor]); Do NOT combine or start within 2 wks of MAOI use
  • Do not combine w/ ergots or within 24 hr of ergot use (e.g., ergotamine/caffeine or cafergot)
57
Q

Headaches: Mild-to-Moderate attacks
- First-line therapy
- General overview

A

FIRST-LINE (before triptans)
- Analgesics (e.g., extra-strength tylenol) or NSAIDs (alone or in combination)

If nausea or vomiting → oral or rectal antiemetic
- Educate pt that it is best to take pain meds as soon as pain starts, rather than waiting until it is severe

58
Q

Headaches: Moderate-to-severe attacks
- First-line therapy
- General overview

A

First-line: Oral triptans or combination sumatriptan-NSAID/naproxen (treximet)

  • If associated with N/V → non-oral agents such as subQ sumatriptan (Imitrix), nasal sumatriptan, and zolmitriptan (Zomig) w/ antiemetic drug
59
Q

Headaches: Newer migraine meds (late 2019)
- General overview

A

Calcitonin gene-related peptide (CGRP) antagonists:
- Rimegepant (Nurtec)
- Urbrogepant (Ubrelvy)

Contraindication: Do not mix with ketoconazole, itraconazole, clarithromycin; do NOT mix w/ grapefruit, St. John’s Wort
- Has number major drug interactions

Erenumab (Aimovig): used to prevent (prophylaxis) both episodic and chronic migraine headaches in adults; made up of monoclonal antibodies
- Autoinjector pen is used once a month at home

Serotonin 5-HT-1F Receptor agonist: Lasmiditan (Reyvow)
- Do NOT use within 8 hrs of driving or operating heavy machinery (causes dizziness)

60
Q

Headaches: Ergotamine/caffeine (Cafergot)
- General overview

A
  • Ergot alkaloids: potent vasoconstrictors
  • Do NOT mix w/ other vasoconstrictors (e.g., triptans, decongestants)
  • Common SE: nausea
  • Ergots and triptans should NOT be given within 14 days of an MAOI
61
Q

Headaches: Antiemetics
- Options
- General overview

A
  • Prochlorperazine: IM, IV, suppository, PO
  • Trimethobenzamide (Tigan): IM, suppository, PO
  • Ondansetron (Zofran): IM, IV, PO. Off-label use for acute severe N/V
62
Q

Headaches: Prophylactic Treatment
- Options
- General overview

A
  • Beta-blockers → Propranolol (Inderal) daily or BID (other beta-blockers can also be used)
  • Tricyclic antidepressants (TCAs) → Amitriptyline (Elavil) at HS
  • Other TCAs: Desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor)
  • SNRI: Venlafaxine (Effexor)
  • Other drug classes: Anticonvulsants (valproate, topiramate)
63
Q

Headaches: Med Contraindications

A

Vasoconstricting drugs
- Suspected or known CVD (angina, MI, peripheral arterial disease)
- Suspected or known CVA and/or TIAs
- HLD, males >40 yo., menopausal females
- uncontrolled HTN
- Complex migraines (e.g., basilar/hemiplegic migraine)

64
Q

Migraine w/ Brainstem Aura (Basilar or Hemiplegic Migraines)
1. Definition/Etiology
2. Clinical Presentation
3. Treatment

A
    • Rare, subset of migraine w/ aura
    • Sx resemble stroke, except not accompanied by hemiplegia
      - Focal neuro findings (stroke-like s/s): unilateral or bilateral hemianopic visual disturbances, vertigo, ataxia, dysarthria w/ bilateral tingling, or numbness of face
      - These are part of the aura
      - followed by throbbing occipital headache and nausea
      - 25% have loss of consciousness lasting 2-30 mins
  1. Can be treated w/ meds used to treat headache w/ aura
65
Q

Giant Cell Arteritis
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A

Aka Temporal Arteritis
1. A systemic inflammatory disorder of the medium and large arteries (vasculitis) of the body
- Acute onset of unilateral headache, located on temple and associated w/ temporal artery inflammation
- Visual loss is not uncommon; occurs in 10-20% of pt (despite availability of steroids)
- Peak incidence: 70-79 years

    • Older man c/o headache on temple along w/ marked scalp tenderness on same side
      - Presence of indurated cord-like temporal, artery; warm and tender
      - sometimes accompanied by jaw claudication (pain w/ chewing, relieved when stop chewing)
      - C/o visual sx → amaurosis fugax, or blindness
      - can be accompanied by systemic s/s: low-grade fever and fatigue
      - Sedimentation ate is markedly ↑
    • Check ESR/sedimentation rate (often reaches 100 mm/hr or more); BOTH elevated
      * Normal range: M 0-22 mm/hr; F 0-29 mm/hr
      - Check CRP, which will be ↑
    • Refer to ophthalmologist or rheumatologist, or refer to ED stat!
      - GOLD STANDARD: Temporal artery biopsy is a definitive test; done by ophthalmologist or surgeon
      - First life: High-dose steroids , prednisone 40-60 mg PO daily

** Treated w/ high-dose prednisone for several weeks; refer to rheumatology specialist for management
** Sedimentation rate is a screening test for this (will be markedly elevated)
- Serial monitoring of ESR, CRP should be ordered until symptoms improve

66
Q

Amaurosis fugax

A

transient monocular loss of vision or partial visual field defect

67
Q

Polymyalgia Rheumatica
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
  1. Inflammatory condition, almost exclusive in people ≥50
    - Peak incidence: 70-79
    - F>M
    - Unknown cause
    - Very high rate (up to 40-50%) of developing temporal arteritis; educate pt on how to recognize sx or temporal arteritis
    • Bilateral joint stuffness and aching (last 30 min or longer, commonly in the morning)
      - aching located on posterior neck, shoulders, upper arms, and hips (pelvic girdle)
      - Pelvic girdle s/s → groin pain, pain at lateral aspects of hips, may radiate to posterior thigh area
      - difficulty putting on clothes, hooking bra in the back, or getting up our of bed/chair
      - Severe morning stiffness (“gel phenomenon”) and pain can last until afternoon if not treated with steroids
      - Sx usually respond quickly to oral steroids (e.g., prednisone daily)
    • ESR elevated mildly to severely (20% sedimentation rate 104 mm/hr); CRP is also ↑
  2. Steroids (prednisone daily)
67
Q

Polymyalgia Rheumatica
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
  1. Inflammatory condition, almost exclusive in people ≥50
    - Peak incidence: 70-79
    - F>M
    - Unknown cause
    - Very high rate (up to 40-50%) of developing temporal arteritis; educate pt on how to recognize sx or temporal arteritis
    • Bilateral joint stuffness and aching (last 30 min or longer, commonly in the morning)
      - aching located on posterior neck, shoulders, upper arms, and hips (pelvic girdle)
      - Pelvic girdle s/s → groin pain, pain at lateral aspects of hips, may radiate to posterior thigh area
      - difficulty putting on clothes, hooking bra in the back, or getting up our of bed/chair
      - Severe morning stiffness (“gel phenomenon”) and pain can last until afternoon if not treated with steroids
      - Sx usually respond quickly to oral steroids (e.g., prednisone daily)
    • ESR elevated mildly to severely (20% sedimentation rate 104 mm/hr); CRP is also ↑
  2. Steroids (daily)
68
Q

Trigeminal Neuralgia
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A

Aka Tic Douloureux
1. Trigeminal nerve (CN V) has 3 divisions:
- Ophthalmic (V1)
- Maxillary (V2)
- Mandibular (V3)
- Most cases caused by compression of nerve root by an artery, vein, or tumor, causing a unilateral facial pain following one of the branches of the CN 5
- Pain usually located close to nasal border and cheeks but can move to other facial areas
- More common in females; peaks at 60s

THREE types:
- Classic
- Secondary (underlying disease)
- Idiopathic

  1. older adult c/o sudden onset of severe rand sharp shooting pains on one side of face or around nose
    - triggered by chewing, eating cold folds, and cold air
    - severe lacerating pain (piercing knifelike pain), lasting few seconds to 2 mins
    - Pain is precipitated by a stimulus on any area of the trigeminal nerve
    - pt may stop chewing or speaking momentarily (few seconds) if pain
    - Has recurrent paroxysms of lateral facial pain → follows distribution of CN V
    • First line: high-dose anticonvulsants (carbamazepine [Tegretol])
      - For pain more severe in mouth area → topical lidocaine intraoral application
      - Muscle relaxants: baclofen, robaxin, norflex, or flexeril; often effective w/ anticonvulsants – oxcarbazepine (Trileptal) most recently used as first-line drug with fever side effects; Gabapentin and topiramate also effective
      - Obtain MRI or CT scan to r/o tumor/artery pressing on a nerve or MS. If MRI detects lesion or arterial/venous compression → Refer to microvascular decompression by craniotomy
      - For refractory cases → surgical therapy (rhizotomy, radiofrequency, nerve block)
69
Q

Bell’s Palsy
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A
  1. Abrupt onset of unilateral facial paralysis d/t dysfunction of motor branch of facial nerve (CN VII)
    - Facial paralysis can progress rapidly w/in 24 hrs
    - Skin sensation remains intact, but tear production on affected side may stop
    - Most cases resolve spontaneously
    - Herpesvirus activation is suspected to be most likely cause of majority of cases
    • older adult report waking up w/ one side of face paralyzed
      - C/o difficulty chewing and swallowing food on same side
      - Unable to fully close eyelid on affected side
  2. Clinical diagnosis
    • Early tx w/ high0dose PO glucocorticoids (60-80 mg/day) x 7 days and wean PLUS valacyclovir (1,000 mg TID) or acyclovir (400 mg 5x/day) x 7 days
      - Best if tx started ASAP, within 3 days of onset
      - Protect cornea from drying and ulceration by applying artificial tears (liquid, gel) Q1H while awake; use protective glasses or goggles
      - At night, use ointment (containing mineral oil and white petrolatum) and cover w/ eye patch
    • Can cause corneal ulceration
      - Prolonged cases (several weeks) may leave permanent neurologic sequelae (e.g., permanent facial weakness, up to 10% of pt)
      - Re current attacks happen in 7-14% of cases
70
Q

Cluster Headache
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A
  1. Idiopathic and severe one-sided headache; marked by recurrent episodes of brief “ice-pick” (lacerating pain), excruciating pain located behind one eye, accompanied by lacrimation, nasal congestion, and clear rhinitis
    - accompanied by conjunctival injection (red eyes), ptosis (droop eyelid), and miosis (pupil constriction) on ipsilateral side (same side as headache)
    - Hx of head trauma or fam hx of cluster headache will ↑ risk

Characteristics:
- Abrupt onset; may get agitated during headache episode
- Attacks happen severe times a day (cluster)
- Individual attack last from 15 min - 3 hrs
- Resolves spontaneously but may return in future in some pts
- More common in adult males in 30s-40s
- ↑ risk of suicide if persists (d/t severe intensity of pain)

    • 35-year-old man c/o abrupt onset of recurrent episodes of brief “ice-pick” (lacerating pain) headaches behind one eye
      - above eye/brow area of temporal area
      - accompanied by autonomic sx: tearing and clear nasal discharge (rhinitis)
      - some may have dropping eyelid (ptosis)
      - may pace the floor during acute attack\
  1. Clinical diagnosis
    INITIAL diagnosis, MRI is recommended to exclude abnormalities in brain and pituitary gland (e.g., aneurysms, AVM, pituitary macroadenoma, meningiomas)
  2. ACUTE Treatment:
    - High-dose oxygen may relieve headache (100% oxygen at least 12 L/min by mask)
    - Continue O2 tx for ~15 mins; do not use high-dose O2 if pt has COPD
    - Administer sumatriptan (Imitrex) 6 mg by SubQ or intranasal route as initial therapy or combination w/ high-dose O2
    - Melatonin 10 mg immediate-release tablet taken in late evening (found to ↓ headache frequency)
    - Capsaicin 0.025% smear on ipsilateral nostril x7 days may help

PROPHYLAXIS:
- If chronic → CCB verapamil PO daily
- Avoid grapefruit juice
- If dose >400 mg, EKG monitor d/t risk of bradycardia, RBBB, or complete heart block

    • ↑ risk of suicide (males) compared w/ other types of chronic headaches
71
Q

Tension-Type Headaches
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A
  1. Emotional/psychic stress in some people → muscles of scalp and neck to become chronically tense (or in contraction)
    - bilateral headache can last for several days
    • “band-like” headache
      - feels like “someone is squeezing my head”
      - dull and constant
      - Often accompanied by tensing of neck muscles
      - headache may last several days
      - reports recent ↑ life stressors
  2. Clinical diagnosis
  3. First-line: NSAIDS (naproxen sodium BID or ibuprofen QID or aspirin Q4-6 hr); acetaminophen if unable to tolerate NSAID
    - If poor response → diclofenac TID
    - If pregnant → acetaminophen
  • Combination drugs such as ibuprofen or aspirin w/ caffeine is an option for pt who do not get satisfactory pain relief from a single agent
  • Limit butalbital uses 3x or less than per month
  • Current guidelines do not recommend use of opioids or butalbital as initial therapy for tension-type headaches (TTH); muscle relaxants are not recommended; they can be addicting for some pts
  • Stress reduction an relaxation: Yoga, tai chi; exercise severe times/errk; gradually ↓ and stop caffeine intake; follow regular eating/sleep schedule; pursue counseling w/ therapist
72
Q

Medication Overuse Headache
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment
5. Complications

A

Aka Rebound Headache
1. Headache occurring ≥ 15 days per month d/t overuse of acute headache medications for >3 months.
- more common in women
- Pts w/ migraine who are depressed or anxious may be at risk
- Caused by overuse of abortive meds such as analgesics, NSAIDs, aspirin, combination NSAID or acetaminophen w/ caffeine, butalbital, barbiturates, ergots, triptans, or opioids

    • c/o daily headaches (or almost daily headaches)
      - may be accompanied by irritability, depression, and insomnia
  1. Clinical diagnosis
  2. To avoid, limit use of OTC analgesics or triptans to ≤ 9 days/month
    - For NSAIDs, limit use to ≤ 15 days/month
    - For butalbital-containing analgesics, limit to ≤ 3 days/month
    - TX: discontinue med immediately (if not contraindicated) or gradually taper dose and/or ↓ frequency
73
Q

Transient Ischemic Attack (TIA)
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
    • TIA: a transient episode of neuro dysfunction caused by focal ischemia (brain, spinal cord, or retinal ischemia) w/o acute infarction of brain as seen in stroke
      - timing for resolution: (24 hrs has been removed); now known that permanent neuro damage can occur w/ TIAs
      - AKA “ministroke” or “minor stroke”
      - pts are at very high risk for severe stroke in the future → needs urgent evaluation and treatment
      ** TIA is a major warning sign; 15% pt w/ -stroke report a previous TIA
      - Major risk factor for stroke: HTN
    • depending on severity, s/s can be subtle to severe; the longer the episode of TIA, the ↑ risk for ischemic brain damage
      - can progress into full-blown stroke
      - s/s can be insidious and start a few days before major episode occurs
      - ABCD2 score → if score ≥3 → Refer to ED
  • acute onset of one-sided weakness of arm/leg
  • accompanied by dizziness, vertigo, and poor balance
  • difficult to understand pt d/t slurred speech (dysphagia)
  • smile/grimace: affected side has no movement and is lopsided
  • accompanied by spouse who reports pt has hx of HTN, A fib, HLD, and DM2
  • if sx progress to stroke → one-sided weakness worsens
  • LOC ranges from confusion and stupor to coma
  • if TIA → s/s eventually resolve, but pt remains at higher risk for future stroke
    ** FAST
  1. CT and/or MRI scan ASAP (within 24 hrs of episode)
    - Diffusion-weighted MRI is preferred imaging
    • REFER TO ED!!! Find out cause of TIA (or stroke), such as Afib/ carotid/vertebral atherosclerosis, hypercoagulable state, cocaine use, HTN; perform workup to find extent of brain damage
      ** Hospitalization criteria
      - R/O intracranial hemorrhage before starting aspirin (50-325 mg/day) + extended-release dipyridamole or clopidogrel
      - Maintain BP <140/90 mmHg
74
Q

ABCD2: Risk factor and points

A

clinical prediction tool helps tp predict who is at high risk for suffering subsequent stroke after TIA within next 7 days → if score ≥ 3 → Refer to ED!

+ Age >65: 1
+ BP: SBP >140, DBP >90: 1
+ Clinical features of TIA (choose one only):
- Unilateral weakness w/ or w/out speech impairment: 2 OR
- Speech impairment w/out unilateral weakness: 1
+ Duration:
- TIA during > 60 mins: 2
- TIA during 10-59 mins: 1
+ Diabetes: 1

Total score: 0-7

75
Q

TIA: Risk factors for Recurrent Ischemic Stroke after TIA

A
  • Age ≥ 60 years
  • Hx of TIA or ischemic stroke within 30 days of index event
  • Hx of diabetes
  • SBP ≥ 140 mmHg or DBP ≥ 90 mmHg
  • Unilateral weakness
  • Isolated speech disturbance
  • TIA duration > 10 mins
76
Q

TIA/Stroke: “FAST” Mnemonic for Recognizing Stroke

A

F - Face dropping (instruct pt to smile. If face lopsided?)

A - Arm weakness (Instruct pt to raise both arms. Does one arm drift downward?)

S - Speech difficulty (Instruct pt to say “the sky is blue”)

T - Time to call 911 (even if sx go away, CALL 911!!)

77
Q

TIA/Stroke: Hospitalization Criteria

A

Consider hospitalization within first 24-48 hr (if high risk of early stroke):
- Presence of known cardiac, arterial, or systemic etiology of brain ischemia that is amenable to tx
- ABCD2 questionnaire score of ≥ 3
- Pt’s first TIA or duration of TIA is ≥ 1 hr
- High risk for cardiac emboli (e.g., Afib)
- Symptomatic internal carotid stenosis > 50%
- Hypercoagulable state
- Crescendo TIAs (2 or more TIAs in 1 week)

78
Q

Cerebrovascular Accident or Stroke
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
  1. Two types: Ischemic (embolic/thrombosis) or hemorrhage (2 types) → leads to permanent damage to brain
    - Most common RF: Afib and HTN
    - Other RF: aneurysms, trauma, bleeding abnormalities, and use of anticoagulants (e.g., warfarin [Coumadin]), use of stimulants (cocain/illicit drugs), sickle cell disease, diabetes, OC use, smoking and thrombophilia
    - Blacks, Hispanics, and American Indians/Alaskan Natives = higher prevalence of stroke
  2. Embolic stroke: (see other notes)
    - abrupt onset of difficulty speaking
    - unilateral hemiparesis
    - weakness of arms/legs (or both)

Hemorrhagic stroke:
- severe headache
- N/V
- photophobia
- nuchal rigidity
- accompanied by hemiparesis & difficulty speaking

  1. Initial: CT w/out contrast
  2. Call 911!
    - Assess ABCs ASAP! Check for airway patency, chest movement, breath sounds from both lungs, and circulation
    - Check VS and neuro status
79
Q

Embolic vs thrombotic vs hemorrhage stroke

A

Embolic → local obstruction of an artery

Thrombotic → debris originating elswhere that blocks an artery

Hemorrhage:
- intracerebral → bleed directly into brain
- subarachnoid → bleed into subarachnoid space and CSF

80
Q

Acute Ischemic Stroke
- Location + clinical presentation

A
  • Stoke d/t emboli that broke off from thrombus formation in body

Common locations; LE and heart (Afib)

S/S depends on artery involved
- MCA is largest cerebral artery; most commonly affected by stroke
► L MCA occlusion of superior branch → R. side of face, R. arm, R. leg weakness; hemianopia; with expressive aphasia (Broca’s area)
► R MCA: left side of face, left arm, left leg w/ hemineglect and possible hemianopia

81
Q

Hemorrhagic Stroke
- Types + clinical presentation
- Hallmark signs

A

SAH or intracerebral hemorrhage (ICH):
- Suddent onset of severe “thunderclap” headache
- described as worst headache of life
- pain from headache may radiate to neck/back
- Rapid ↓ LOC (coma, death)
- SAH usually begins abruptly compared w/ more gradual ICH

  • Vomiting is more common in hemorrhagic strokes (compared to embolic); usually caused by ruptured aneurysm or vascular malformations
  • “Sentinel headache” may be seen in SAH. ~30% of pt have minor hemorrhagic episodes w/ sudden severe headache as the only sx
82
Q

CVA: ED Management

A
  • Asses ABCs and stablize pt
  • Initial imaging in ED: CT scan WITHOUT contrast then MRI study
  • Time is critical!! Do NOT delay antithrombolytic therapy
  • Check blood glucose (must be <180 mg)
  • Per AHA: Alteplase can be give up to 4.5 hrs from start of symptoms
83
Q

CVA: Screening for Visual Field Loss
Homonymous hemianopia

A
  • Visual field loss involving either 2 left halves (or the 2 right halves) of the visual field
  • Most common cause: Stroke
  • Many types of hemianopia

Perform screening test: Visual fields by confrontation

Ex: Left-sided Homonymous Hemianopia
The diagram shows intact and missing visual fields of a person who has left-sided homonymous hemianopia. “X” signifies missing visual fields and the “–” are intact visual fields

Left eye
xxxxx====
xxxxx====
xxxxx====

Right eye
xxxx====
xxxx====
xxxx====

84
Q

Examples of Brain Damage: Temporal Lobe - Apraxia

A

Difficulty performing purposeful movements

85
Q

Examples of Brain Damage: Temporal Lobe - Broca’s aphasia

A

AKA “Expressive aphasia”

Pt comprehends speech relatively well (and can red) but has extreme difficulty w/ motor aspects of speech

Speech length is usually < 4 words

86
Q

Examples of Brain Damage: Temporal Lobe - Wernicke’s aphasia

A

AKA “Receptive aphasia”

Pt has difficulty w/ comprehension but has no problem w/ producing speech
- Reading and writing can be markedly impaired

87
Q

Examples of Brain Damage: Temporal Lobe - Front lobe damage

A

Front lobes are areas where intelligence, executive skills, logic, and personality reside

  • Damage will cause dementia, memory loss/difficulties, inability to learn
88
Q

CVA: Long-Term Management

A

Tx includes:
- BP reduction
- Statins
- Antiplatelets
- Anticoagulants
- Carotid revascularization

  • Lifestyle and dietary changes to ↓ stroke risk

For EMBOLIC STROKES:
- anticoagulation therapy
- statin therapy
- keep INR between 2.0 - 3.0

For HEMORRHAGIC STROKES:
- Avoid heparin, warfarin, aspirin, NSAIDs

Rehabilitation:
- PT, OT, SLP

Patient should be under care of a neurologist

89
Q

Common Drugs: Headache Treatment
Acute treatment (PRN only)

A

NSAIDs
- Naproxen sodium (Naprosyn, Aleve) BID or ibuprofen (Advil, Motrin) TID-QID
- SE: GI pain/bleeding/ulceration, renal damage, ↑ BP in HTN

Triptans
- Administer sumatriptan succinate (Imitrex) injection, inhalant, PO tablets, or sublingual tablets. For acute pain → give injection subQ (onset 10 mins)
- SE: Nausea, dizzines, vertigo, drowsiness, discomfort of throat, nose, and/or tongue
- Contraindicated: pts w/ CVD comorbidities since it causes vasoconstriction (coronary artery spasm, MI, transient myocardial ischemia), arrhythmias (Afib, Vfib, Vtach)
- Triptans should not be given within 24 hrs of an ergot
- Do not give within 14 days of an MAOI

Analgesics
- Acetaminophen (Tylenol) QID PRN
- SE: hepatic damage
- Prophylaxis (must be taken to work daily)

90
Q

Common Drugs: Headache Treatment
Prophylaxis

A

Tricyclic Antidepressants
- Amitriptyline (Elavil), nortriptyline, doxepin, or imipramine
- SE: Sedation, dry mouth, confusion in older adults

Beta-Blockers
- Propranolol (Inderal LA) or atenolol (Tenormin) daily
- Careful w/ older pts
- Contraindications: Second- or third-degree atrioventricular (AV) block, asthma, COPD, bradycardia

SNRIs
- Venlafaxine (Effexor) daily at HS
- Consider if pt has both migraine and depression, generalized anxiety ds, panic ds, chronic anxiety

Antiseizure Meds
- Topiramate (Topamax)
- If d/c drug, withdraw gradually over a few weeks to minimize risk of seizures or withdrawal symptoms

91
Q

Carpal Tunnel Syndrome
1. Definition/Etiology
2. Clinical Presentation
3. Lab/Diagnostics
4. Treatment

A
  1. Median nerve compression d/t swelling or carpal tunnel
    - Commonly caused by activities that require repetitive wrist/hand motion
    - Both hands affected in 50%
    - RF: Hypothyroidism, pregnancy, RA, and obesity
    - More common in females
    • adult female c/o gradual onset (over weeks to months) of numbness and tingling (paresthesias) on thumb, index finger, and middle finger areas
      - hand grip of affected hand(s) is weaker
      - may c/o problems lifting heavy objects w/ affected hand
      - sx worsened by repetitive actions of hand or wrist and during sleep
      - chronic severe cases involve atrophy of thenar eminence (the group of muscles on palm of hand at the base of thumb), which is a late sign
      - Hx of an occupation or hobby that involves frequent wrist/hand movements

PE findings:
- Tinel’s sign
- Phalen’s sign
* Both signs for carpal tunnel syndrome or compression of median nerve

  • Instead of being called CTS, may be called inflammation of median nerve
92
Q

Tinel’s Sign

A
  • Tap anterior wrist briskly
  • POSITIVE: “Pins and needles” sensation of median nerve over hand after lightly percussing the wrist
93
Q

Phalen’s Sign

A
  • Engage in full flexion of wrist for 60 seconds
  • POSITIVE: Tingling sensation of mediian never of hand evoked by passive flexion of wrist for 1 min