Adolescents Flashcards

1
Q

Danger Signals! Acetaminophen Poisoning + Staging

A

Intentional Ingestion
- Acetaminophen damages liver → mild-severe fulminant liver failure
- AKA paracetamol and sold as Tylenol and others

Stage 1 (up to 24 hours after overdose)
- pt usually asymptomatic but may have N/V and w/ very large doses, lethargy and malaise

Stage II (18-72 hrs after overdose)
- Pt c/o RUQ pain w/ abdominal pain, N/V, and ↑ LEFTs, prothrombin time and bilirubin concentrations
- possible nephrotoxicity (↑ BUN, creatinine)

Stage III (72-96 hrs after overdose)
- hepatic necrosis present as jaundice, clotting ds, hypoglycemia, and hepatic encephalopathy
- AKI w/ oliguria may develop
- m ost deaths from organ failure occur within 72-96 hrs

With acute overdose, serum acetaminophen concentration should be measured ASAP, but at least 4 hours must have passed since ingestion to obtain accurate blood level (if <4 hrs, blood level is not accurate)

Antidote: N-acetylcysteine given IV

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2
Q

Danger Signals! Testicular Torsion

A

Acute Scrotum
- pubertal male awakens w/ abrupt onset of unilateral testicular pain, increases in severity
- pain may radiate to lower abdomen and/or groin
- ~90% of patients have N/V

Ischemic changes → severe scrotal edema, redness, and testicular pain
- Ipsilateral (same side) cremasteric reflex is absent
- testicle may be noted to be high riding w/ a transverse lie

Highest incidence is during adolescence

  • May be confused w/ torsion of appendix testis (more common in prepubertal boys, less N/V, “blue dot sign”)
  • UA is neg for puria and bacteruria
  • Doppler US is initial diagnostic test
  • Testicle is not functional after 24 hrs if not repaired

→ Refer to ED! Surgical emergency!

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3
Q

Danger Signals! Testicular Cancer

A
  • teenage-to-adult male c/o “heaviness” in scrotum or hardened mass that is usually painless
  • some pt may have testicular discomfort or numbness but not pain
  • affected testicle has a firm texture
  • more common in males 15-35 years
  • Cryptorchidism is a strong risk factor
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4
Q

Danger Signals! Hodgkin’s Lymphoma

A
  • Pt presents w/ enlarged and painless cervical, axillary, groin, and supraclavicular lymphadenopathy associated w/ fever (Pel-Ebstein sign) +
  • fatigue
  • unexplained weight loss
  • night sweats
  • may report having severe pain on or over malignant areas a few mins after drinking alcohol
    ** most common CA in teenagers 15-19 years are Hodgkin’s lymphoma (16%) and germ cell tumors (16%) such as testicular and ovarian cancer

** Hodgkin’s lymphoma presents as enlarged lymph nodes w/ fever, night sweats, and pain (lymph nodes) after drinking alcohol

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5
Q

Pel-Ebstein sign

A

enlarged and painless cervical, axillary, groin, and supraclavicular lymphadenopathy associated w/ fever (Pel-Ebstein sign) +
- fatigue
- unexplained weight loss
- night sweats

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6
Q

Normal Findings: Adolescence (defined)

A

onset of puberty until sexual maturity

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7
Q

Top 3 causes of death (15-19 years)

A
  1. Accidents (e.g., MVA)
  2. Suicide (e.g., intentional suffocation)
  3. Homicide (e.g., intentional firearm use)
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8
Q

Normal Findings: Puberty (defined)

A

period in life when secondary sexual characteristics start to develop because of hormonal stimulation

Girls’ ovaries start producing estrogen and progesterone

Boys’ testes start producing tesosterone

All these changes → reproductive capability

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9
Q

Puberty: Girls - Precocious vs delayed

A

Precocious puberty if puberty starts before 8 years

Delayed if no breast development (Tanner stage II) by 12 years

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10
Q

Puberty: Girls - Growth Spurt

A
  • majority of physical changes occur b/w ages 10-13 years
  • majority of skeletal growth occurs before menarche; afterward, growth slows down
  • girls start their growth spurts approx 2 years earlier than boys
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11
Q

Puberty: Girls - Pubertal Timeline

A

Breast development → peak growth acceleration → menarche

  • most of a girl’s height is gained before menarche
  • skeletal growth sin girls is considered complete within 2years after menarche
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12
Q

Puberty: Girls - Mittelschmerz

A

Ovulation Pain
- unilateral midcycle (about 14 days before the next period) pelvic pain that is caused by an enlarging ovarian follicle or the rupture of the follicle at the time of ovulation
- pain may last a few hours to a few days
- may occur intermittently

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13
Q

Puberty: Girls - Menarche

A
  • Avg age is ~122 years (12.34 years) in US (range 8-15 years)
  • First 1-2 years after onset of menarche, common to have irregular periods because of irregular ovulation (may skip a month or longer intervals, lighter bleeding)
  • after Tanner stage II starts (breast bud stage), girls start menses within 2 years
  • delayed puberty is determined if no breast development by age 13 or menarche does not begin by 15 years
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14
Q

Puberty: Girls - Menstrual Cycle

A
  • average duration: 28 days
  • in younger teens, cycles range from 21-45 days
  • in adults, they can range from 21-35 days
  • avg duration of menstrual bleeding is ~3-5 days (range 2-7 days)
  • Day 1 of menstrual cycle start as spotting; then blood flow becomes heavier for 2-3 days, then bleeding lightens until it stops
  • most fertile period in the cycle is ~3 days before and during ovulation (days 11-14)
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15
Q

Puberty: Girls - Dysmenorrhea

A
  • painful periods are d/t severe menstrual cramps caused by high levels of prostaglandins
  • Tx is use of heating pads and NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve)
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16
Q

Puberty: Boys - Precocious ve delayed

A

Precocious puberty if starts before 9 years

Delayed if no testicular enlargement by age 14

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17
Q

Puberty: Boys - Growth Spurt

A
  • approx 2 years later than girls’ (age 11-15 years)
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18
Q

Puberty: Boys - Spermarche

A
  • average age is 13.3 years
19
Q

Tanner Stages: Boys

A

Stage I - prepuberty

II - Testes begin to enlarge, w/ increased rugation of scrotum

III - penis elongates; testicular/scrotal growth continues; scrotal color starts to darken

IV - penis thicken sand ↑ in length; testes are larger and scrotal skin darkens

V - adult pattern

  • Puberty starts at Tanner stage II in girls or boys; puberty ends at Tanner stage V; know these stages (II-V)
20
Q

Tanner Stages: Girls

A

Stage I - Prepuberty
II - Breast bud (onset of thelarche, or breast development)
III - Breast tissue and areola are in one mount
IV - Areola/nipples separate and form a secondary mount
V - Adult pattern

  • Puberty starts at Tanner stage II in girls or boys; puberty ends at Tanner stage V; know these stages (II-V)
21
Q

Pubic Hair (both genders)

A

Stage I - Prepuberty
II - Sparse growth of straight hair, easily counted
III - Hair is darker and starts to curl
IV - hair is curly but not on medial thigh yet as in adult; hair is coarser
V - Adulit pattern; hair spreads to medial thigh and lower abdomen

22
Q

Immunization Schedule for Adolescents (ages 11-18): Tdap

A

Boostrix, Adacel
- All 11-12 years → Give Tdap as booster and Td Q10 years for lifetime

23
Q

Immunization Schedule for Adolescents (ages 11-18): HPV

A

Gardasil
- All 11-12 year old → give to girls and boys
- Minimum age: 9 years
- All 11-12 years → Give 1st shot, needs 2 doses, 6-12 months apart
- Age 15026 years: need 3 dosease

24
Q

Immunization Schedule for Adolescents (ages 11-18): Meningococcal (ACQWY-D [Menactra], MenACWY-CRM [Menveo], MenB-4C [Bexsero], MenB-FHbp [Trumenba])

A
  • All 11-12 years → give single dose of Menactra or Menveo vaccine, w/ booster at age 16
  • Catch-up: Age 13-18 years, give Menactra or Menveo; if 1st dose at age 13-15 years, need booster at age 16-18; if first dose at age 16 years, no booster dose is needed
  • Clinical discretion: young adults 16-23 years may be vaccinated w/ either Bexsero or Trumenba

** Meningococcal vaccine is recommended for all, starting at 11-12 years (not just for college freshmen living in dormitories)

25
Immunization Schedule for Adolescents (ages 11-18): Influenza Inactivateds
Vaccinate everyone from age 6 months and older annually
26
Immunization Schedule for Adolescents (ages 11-18): Hepatitis B
Recombivax HB) - Catch-up: Give remaining doses if not completed
27
Immunization Schedule for Adolescents (ages 11-18): Hepatitis A
HAVRIX, VAQTA - Catch-up: give 2nd dose if not completed - Recommended for children w/ certain health/lifestyle conditions placing them at risk
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Immunization Schedule for Adolescents (ages 11-18): MMR`
Catch-up: Give 2nd dose if not completed
29
Immunization Schedule for Adolescents (ages 11-18): Varicella
- If no reliable hx of chickenpox (verbal okay) - live virus precautions
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Vaccine Adverse Event Reporting System (VAERS)
government program to report clinically adverse events
31
Lab tests: Elevated Alkaline Phosphatase
- children and adolescents normally have higher blood levels compared w/ adult d/t growing bone - produced by osteoblasts
32
Legal Issues: Right to Consent and Confidentiality
No parental (or guardian) consent is necessary for the following: - Contraception - Treatment for STDs - Diagnosis and management of pregnancy ** No parental consent is needed for health services r/t sexual activity (STD testing, pregnancy tests, birth control prescriptions) * If not related to sexual activity, then need parental consent (dysmenorrhea, headache, upper respiratory infection [URI])
33
Legal Issues: Emancipated Minor Criteria
These minors may give full consent as an adult without parental involvement - Legally married - active duty in armed forces ** Memorize criteria for an emancipated minor - Do NOT confuse right to confidentiality w/ emancipated minor status
34
Legal Issues: Confidentiality
Confidentiality can be broke in the following situations: - Gunshot wounds and stab wounds, which must be reported to the police (regardless of victim's age) - Child abuse (actual or suspected abuse), which must be reported to the authorities - Suicidal ideation and/or attempt (discharge to parents/guardians or hospital) - Homicidal ideation or intent (esp mental health providers)
35
Health Promotion: High-risk behaviors for screening
Adolescent health history is obtained from both parent and child initially; then the adolescent is interviewe4d alone w/out parent During physical exam or wellness visit, assess teenager for high-risk behaviors - Intensive behavior counseling is recommended Following are high-risk behaviors to screen for: - Sexual activity → use of condoms, birth control, intimate partner violence (e.g., rape), s/sx of STDs - Safety → driver safety (seatbelt/helmet use); assess to guns/gun safety; smoking, alcohol, and drug use - Mental health → s/sx of depression and antisocial behaviors (e.g., gangs)
36
Delayed Puberty 1. Definition/Etiology 2. Labs
1. - absence of secondary sexual characteristics by age of 13 for girls (such as breast bud) or at the age of 14 for boys - child remains in Tanner stage I (prepubertal) 2. - Serum pregnancy test - Check prolactin level; if prolactin level is ↑, next step is to order CDT scan of sella turcica (location of pituitary gland inside skull) - For primary amenorrhea 9no menses by age 15), R/O hypogonadism by checking hormone levels (e.g., FSH, LH, TSH) - R/O chromosomal disorders, absence of uterus/vagina, and imperforate hymen - X-ray of the hand is used for estimating "bone age" → when long-bone epiphyses (growth plates) are fused, skeletal growth is finished → Refer to pediatric endocrinologist if no growth spurt, delayed puberty, others
37
Primary and Secondary Amenorrhea (defined) 1. Definition/Etiology 2. Labs 3. Treatment Plans 4. Complications
1. Primary amenorrhea → No menarche by age 15 year sin presence of normal growth and secondary sex characteristics - nearly half of cases are caused by chromosomal disorders (43%) such as Turner syndrome Secondary amenorrhea → no menses for > 3 cycles or 6 months if previously had menses - most common cause is pregnancy - others are ovarian disorders, stress, anorexia, and PCOS Secondary Amenorrhea associated w/ Exercise and Underweight - excessive exercise and/or sports participation has a higher incidence of amenorrhea (and infertility) because of relative caloric deficiency - "Female athlete triad" → anorexia nervosa/restrictive eating, amenorrhea, and osteoporosis 2. - Pregnancy test (serum human chorionic gonadotropin [HCG]) - serum prolactin level (R/O prolactinoma-induced amenorrhea) - serum TSH; also FSH and LH (R/O premature ovarian failure) - If amenorrhea for >6 months, measure bone density 3. - Educate about ↑ caloric intake and ↓ exercise - Prescribed calcium w/ Vit D 1,200-1,500 mg daily and vit E 400 IU daily 4. - Osteopenia/osteoporosis (stress fractures) - Myocardial atrophy, arrhythmia (sudden death), bradycardia, hypotension - Hypoglycemia, dehydration, electrolytes - Lanugo (fine, downy hair), telogen effluvium (hair loss), xerosis (dry skin), infertility - Low BMI, cachexia, anemia, respiratory failure
38
Anorexia Nervosa 1. Definition/Etiology 2. Clinical Findings/Clinical Presentation
1. - usually onset is during adolescence - involves an irrational preoccupation w/ and intense fear of gaining weight 2 types: - patient engages in restriction (dieting, excessive exercise) - binge eating and purging Ex of purging → excessive use of laxatives, enemas, diuretics, and vomiting 2. - Marked weight loss (BMI ≤18.5), bradycardia (40-49 bpm), VS unstable, hypotension - Lanugo (↑ lanugo, esp in face, back, and shoulders) - Osteoporosis or osteopenia - Swollen feet (low albumin), dizziness, abdominal bloating Exam tip* recognize how anorexia pts present (e.g., lanugo, peripheral edema, amenorrhea, significant weight loss >10% of body weight) - ↑ risk of osteoporosis or osteopenia → For birth control, avoid Depo Provera and other progesterone-only contraceptives because they can cause bone loss - Low albumin level results in peripheral edema
39
Gynecomastia 1. Definition/Etiology 2. Clinical Presentation 3. Objective Findings 4. Treatment Plan
1. - Excessive growth of breast tissue in males - can involve 1-2 breasts - physiologic gynecomastia is benign - more common during infancy and adolescence - normal in up to 40% of pubertal boys (peaks at 14 years) - most cases resolve spontaneously within 6 months-2 years 2. - gradual onset of enlarged breasts - or asymmetrical breast tissue (one may be larger) - child is embarrassed and scared about breast changes - affected breast may be tender to palpation 3. - Round, rubbery, and mobile mound (dislike) under areola of both breasts - skin has no dimpling, redness, or changes - if mass is irregular, fixed, or hard, or rapid growth in breast size or if suspect secondary cause → refer to specialist 4. - Evaluate for Tanner stage (check testicular size, pubic hair, axillary hair, body odor) - Check for drug use: Both illicit and prescription (e.g., steroids, cimetidine, antipsychotics) - R/O serious etiology (e.g., testicular or adrenal tumors, brain tumor, hypogonadism) - Recheck patient in 6 months to monitor for changes
40
Pseudogynecomastia 1. Definition/Etiology 2. Labs
1. - bilateral enlarged breast is d/t fatty tissue (adipose tissue) - common in obese boys and men - both breasts feel soft to touch and are not tender - no breast bud or disklike breast tissue is palpable 2. None. Diagnosed by clinical presentation
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Adolescent Idiopathic Scoliosis 1. Definition/Etiology 2. Clinical Presentation 3. Screening Test 4. Treatment Parameters 5. Management
1. - Lateral curvature of the spine that may be accompanied by spinal rotation - more common in girls (80%) - Scoliosis will most likely worsen (66% of cases) if it starts in beginning of the growth spurt - Rapid worsening of curvature is indicative of secondary causes (e.g., Marfan or Ehlers-Danlos syndrome, cerebral palsy, myelomeningocele) 2. - painless and asymptomatic - may c/o that one hip, shoulder, breast, or scapula is higher than the other - no complaints of pain 3. - Adam's Forward Bend Test - Bend forward w/ both arms hanging free - look for asymmetry of spine, scapula, thoracic, and lumbar curvature - check height - measure the Cobb angle (degree of spinal curvature) - full spine x-rays are used to measure degree or curvature 4. - Curves <20º → observe and monitor for changes in spinal curvature - Curves of 20-40º → bracing (e.g., Milwaukee brace) - Curves of >40º → Surgical correction w/ Harrington rod used on spine and other options 5. - Check Tanner stage (Tanner stages II-V) - Order spinal x-ray (posteroanterior [PA] view) to measure Cobb angle - Refer ALL patients w/ scoliosis to a pediatric orthopedic specialist! ** Scoliosis treatment needed for a ≥20º curve; for curves <20 º, observe for worsening
42
Osgood-Schlatter Disease 1. Definition/Etiology 2. Clinical Presentation 3. Diagnostics/Treatment Plan
1. - common cause of knee pain in young athletes - caused by overuse of knee - repetitive stress on patellar tendon by quadriceps muscles causes pain, tenderness,and swelling at tendon's insertion site (tibial tuberosity) - usually affects one knee but can be bilateral - most common during rapid growth spurts in teenage males who are physically active and/or play sports that stress the patellar tendon (e.g., basketball, soccer, running) - condition abates when growth stops 2. - teen undergoing rapid growth spurt c/o tender bony mass over anterior tubercle of one knee - pain is worsened by some activities (squatting, kneeling, jumping, climbing up stairs) - knee pain improves w/ rest and avoidance of aggravating activity - reports presence of bony mass on anterior tibial tubercle; slightly tender - almost all causes resolve spontaneously within a few weeks to months - R/O avulsion fracture (tibial tubercle) if acute onset of pain posttrauma → order lateral x-ray of knees 3. - RICE (Rest affected knee; use ice pack 3x daily - avoid aggravating activities/sports that typically reduce or resolve pain - may continue to play based on degree of pain after sports participation - play doe snot necessarily worsen condition - use acetaminophen (Tylenol) or NSAIDs for pain PRN - Quadriceps strengthening and quadriceps/hamstring stretching exercises aimed at stabilizing knee joint may also be beneficial
43
Klinefelter Syndrome 1. Definition/Etiology 2. Clinical Presentation 3. Labs 4. Diagnostics/Treamtent Plan
1. condition in which males are born w/ extra X chromosome (e.g., 47, XXY) - condition occurs approx in 1/1,000 live births - one of the causes of primary hypogonadism (deficiency in testosterone)\ 2. - testicles are small and firm w/ small penis - tall stature, wider hips, and reduced facial/body ahir, higher risk of osteoporosis (compared w/ normal males) 3/4. Treatment includes testosterone replacement and fertility treatment
44
Turner's Syndrome 1. Definition/Etiology 2. Clinical Presentation
1. females w/ complete or partial absence of second sex chromosome (45, X); - occurs in approx 1/2,5000 live-born females - congenital lymphedema of hands and feed, webbed neck, high-arched palate, and short fourth metacarpal 2. - short stature (height usually below 50th percentile) - Ovarian failure, cardiovascular and renal issue sor ear malformations and other health problems (as well as amenorrhea d/t premature ovarian failure [infertility])