Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2020 Phase 3a (DB) > psychdrugs > Flashcards

psychdrugs Flashcards

1
Q

which receptor do SSRIs work on?

A

5HT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the side effects of SSRIs?

A 
nausea
vomiting
diarrhoea
agitation
insomnia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how to prevent serotonin syndrome?

A

stop ssris 2 weeks before starting maois

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the triad of symptoms for serotonin syndrome?

A

autonomic instability - fever, hypotherm, sweating, bp
neuromuscular excitability
altered mental status

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how is serotonin syndrome treated?

A

stop drug
anti-hypertensives
benzodiazepines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how is severe serotonin syndrome treated?

A

chlorpromazine / cyproheptadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How long does it take for SSRIs to work?

A

4-6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

when to review SSRIs?

A

2 weeks

1 week if suicidal/under 30

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which receptors does TCA bind to?

A

H1 histamine receptor - sedation
Muscarinic ACh inhibitor - cholinergic SEs
alpha-adrenergic - postural hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which arrhythmias does TCA cause?

A 
tachy, then wide complex tachy, then ventricular arrhythmias
prolonged QRS (>2 small boxes)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the main cardiovascular risk of TCAs?

A

prolonged qrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how is prolonged qt treated in tcas?

A

iv sodium bicarbonate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the side effects of TCAs

A 
arrhythmias
sedation
postural hypotension
dry mouth
constipation
blurred vision
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the side effects of lithium?

A 
Lethargic
Insides - GI disturbance
Tremor (fine, if tox, coarse)
Hypothyroidism
Insipidus - polyuria, dipsia, normal glucose!
Urine - as above
Metallic taste
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

which tremor is seen as a side effect of lithium?

A

fine tremor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which tremor is seen as a side effect of lithium toxicity?

A

coarse tremor

17
Q

what pathways is dopamine involved in?

A

mesolimbic

mesocortical

nigrostriatal

tuberoinfundibular

18
Q

how is the mesolimbic pathway affected in psychosis?

A

increased dopamine leads to positive symptoms of psychosis

19
Q

how is the mesocortical pathway affected in psychosis?

A

decreased dopamine in mesocortical - negative symptoms - apathy, etc

20
Q

how is the nigrostriatal pathway affected in psychosis?

A

nigrostriatal is responsible for initiating movement

not affected in psychosis

21
Q

how is the tuberoinfundibular pathway affected in psychosis?

A

dopamine inhibits prolactin

normal in psychosis

22
Q

how do antipsychotics affect the tuberoinfundibular pathway?

A

decreased dopamine - increased prolactin - galactorrhoea

23
Q

how do antipsychotics affect the nigrostriatal pathway

A

decreased dopamine, parkinsonism and EPSEs

24
Q

why do first gen antipsychotics have more side effects?

A

less selective, affect the tuberoinfundibular and nigrostriatal pathways too.

25
Q

list some typical antipsychotics?

A

haloperidol
flupentixol
zuclopenthixol
chlorpromazine

26
Q

list some atypical antipsychotics

A

olanzipine
risperidone
quetiapine
aripiprizole

27
Q

what class of drug is clozapine?

A

atypical atypical

28
Q

which two antipsychotics are most associated with weight gain?

A

olanzipine and clozapine

29
Q

what are the side effects of antipsychotics

A 
weight gain
reduced seizure threshold
anticholinergic side effects
prolonged QT
neuroleptic malignant syndrome
30
Q

How is NLMS differenitated from serotonin syndrome

A 
nlms = has raised CK, slower onset
Serotonin = has hyperreflexia, dilated pupils, faster onset
31
Q

what are the symptoms of nlms?

A 
rigidity
increased wcc
increased CK
variable bp
fever
tachy
sweating
altered mental state
32
Q

what is the treatment for nlms?

A

stop antipsychotic, supportive

33
Q

what triggers serotonin syndrome?

A

mix SSRI
cocaine
ecstasy

34
Q

what are the side effects of clozapine?

A

agranulocytosis
constipation - paralytic ileus
myocarditis - chest pain

35
Q

what do you monitor for clozapine/

A

fbc

ecg

36
Q

which drugs interact with antipsychotics?

A

levodopa cancels out
metoclopramide increases EPSEs
antiepileptics, antibiotics (clarithromycin)
drugs that prolong qt - citalopram

2020 Phase 3a (DB) (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions