Psych Treatment Flashcards

1
Q

Treatment for ADHD

A
  • Stimulants (methylphenidate)
  • CBT
  • Alternatives: atomoxetine, guanfacine, clonidine
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2
Q

Rett Syndrome

A
  • X-linked dominant
  • Girls, age 1-4
  • REGRESSION - loss of development, loss of verbal abilities, intellectual disability, ataia, stereotyped HAND-WRINGING
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3
Q

Treatment for Conduct Disorder

- Violating basic rights of others or societal norms (aggression, destruction, theft)

A

CBT

- Antisocial personality disorder

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4
Q

Treatment for Oppositional Defiant Disorder

- Hostile to authority figures

A

CBT

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5
Q

Treatment for Separation Anxiety Disorder

A

CBT
Play therapy
Family therapy

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6
Q

Treatment for Tourette Syndrome

A

Psychoeducation and behavioral therapy
For intractable/distressing tics: high-potency antipsychotics (fluphenazine, pimozide), tetrabenazine, guanfacine, clonidine

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7
Q

Treatment for Delirium?

A

Treat underlying condition
Haloperidol used as needed
Benzodiazepines for alcohol withdrawal

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8
Q

Treatment for schizophrenia?

A

Atypical antipsychotics (Risperidone)

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9
Q

Treatment for bipolar?

A
Mood stabilizers (lithium, valproic acid, carbamazepine)
Atypical antipsychotics
AVOID ANTIDEPRESSANTS (can precipitate mania)
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10
Q

Treatment for depression?

A

CBT and SSRIs are first line
SNRIs, mirtazapine, buproprion can also be considered
ECT in select patients

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11
Q

Treatment for depression with atypical features?

A

CBT and SSRIs are first line

MAOi are effective but have lots of AE

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12
Q

Treatment for postpartum blues?

A

Supportive

Follow-up to assess for postpartum depression

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13
Q

Treatment for postpartum depression?

A

CBTs and SSRIs

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14
Q

Treatment for postpartum psychosis?

A

Hospitalization and initiation of atypical antipsychotic

ECT may be used

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15
Q

Treatment for panic disorder?

A

CBT, SSRIs, venlafaxine are first line

Benzodiazepines for acute attack

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16
Q

Treatment for specific phobia?

A

Systemic desensitization

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17
Q

Treatment for social anxiety disorder?

A

CBTs, SSRIs, and venlafaxine are first line

Benzodiazepine or Beta-blocker for occasional anxiety-inducing situations

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18
Q

Treatment for agoraphobia?

A

CBT, SSRIs, MAOi

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19
Q

Treatment for generalized anxiety disorder?

A

CBT, SSRIs, SNRIs are first line

Buspirone, TCAs, benzodiazepines are 2nd line

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20
Q

Treatment for adjustment disorder?

A

CBT, SSRIs

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21
Q

Treatment or OCD?

A

CBT, SSRIs, clomipramine

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22
Q

Treatment for body dysmorphic disorder?

A

CBT

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23
Q

Treatment for PTSD?

A

CBT,SSRIs, venlafaxine

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24
Q

Treatment for acute stress disorder?

A

CBT, pharmacotherapy not indicated

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25
Treatment for anorexia nervosa?
Psychotherapy and nutritional rehabilitation are first line | - Watch out for Refeeding Syndrome (increased insulin --> hypophosphatemia --> cardiac complications)
26
Treatment for bulimia nervosa?
Psychotherapy, nutritional rehabilitation, antidepressants
27
Treatment for binge eating disorder?
Psychotherapy (CBT) is first line, SSRIs
28
Treatment for narcolepsy?
Daytime stimulants (amphetamines, modafinil) and nightime sodium oxybate (GHB)
29
Methadone
- Heroin detox or long-term maintenance | - Long-acting oral opiate
30
Naloxone + Buprenorphine
- Antagonist + partial agonist - Naloxone is not orally bioavailable, so withdrawal sx occur if injected (lower abuse potential) - QUICK
31
Naltrexone
- Long acting opioid antagonist | - Use for relapse prevention once detoxified
32
Treatment for alcoholism?
- Disulfiram (abstain from alcohol use) - Acamprosate, naltrexone, supportive care - Alcoholics Anonymous
33
Treatment for Wernicke-Korsakoff?
IV Vitamin B1
34
Treatment for alcohol withdrawal?
Benzos (chlordiazepoxide, lorazepam, diazepam)
35
Methylphenidate Dextroamphetamine Methamphetamine
- Increases catecholamines in synaptic cleft (especially NE and DA) - ADHD, narcolepsy, appetite control
36
Antipsychotics (ZINE) - Haloperidol - Trifluoperazine - Fluphenazine - Thioridazine - Chlorpromazine
- MOA: block D2 R --> increase cAMP - Use: schizophrenia (+ sx), psychosis, bipolar, derlirium, Tourette syndrome, Huntington DZ, OCD -
37
High Potency Antipsychotics
- Trifluoperazine, Fluphenazine, Haloperidol | - Neuro AE (extrapyramidal sx)
38
Low Potency Antipsychotics
- Chlorpromazine, Thioridazine - Non-neuro AE (anticholinergic, antihistamine, alpha1-blockade effects) - SEDATION, orthostatic hypotension
39
Chlorpromazine AE
Corneal deposits
40
Thioridazine AE
Retinal depositis
41
Haloperidol AE
Neuroleptic malignant syndrome, tardive dyskinesia
42
Neuroleptic Malignant Syndrome
Rigidity, myoglobinuria, autonomic instability, hyperpyrexia | - Rx: dantrolene, D2 agonists (bromocriptine)
43
Tardive Dyskinesia
Orofacial chorea as result of long-term antipsychotic use
44
General Antipsychotic AE
- Highly lipid soluble and stored in body fat --> slow to be removed from body - Extrapyramidal systemi AE (dyskinesias) --> Rx: benztropine, diphenhydramine, benzos - Endocrine AE due to DA R antagonistm --> hyperprolactinemia --> galactorrhea, oligomenorrhea, gynecomastia - AE arising from blocking muscarinic (dry mouth, constipation), alpha1 (orthostatic hypotension), and HA (sedation) R - Cause QT prolongation
45
Onset of EPS
- Hrs-days: ACUTE DYSTONIA (muscle spasm, stiffnes, oculogyric crisis) - Days-mo: AKATHISIA (restlessness) and PARKINSONISM (bradykinesia) - Mo-yrs: TARDIVE DYSKINESIA
46
Atypical Antipsychotics - Ariprazole - Aenapine - Clozapine - Iloperidone - Lurasidone - Olanzapine - Paliperidone - Quetiapine - Risperidone - Ziprasidone
- MOA: most are D2 antagonists with varied effects on 5-HT2, DA, alpha, and H1 R - Use: schizophrenia (+ and - sx), bipolar, OCD, anxiety disorder, depression, mania, Tourettes - AE: prolonged QT - FEWER EPS AND ANTICHOLINERGIC AE THAN TYPICAL ANTIPSYCHOTICS
47
Ariprazole MOA
D2 partial agonist
48
"Pines" AE | - Cloazpine, Asenapine, Olanzapine, Quetiapine
Metabolic syndrome - weight gain, diabetes, hyperlipidemia - Check fasting glucose and lipid panel at checkups - Olanzapine = obesity
49
Clozapine AE
Agranulocytosis (monitor WBC weekly)
50
Risperidone AE
Hyperprolactinemia (amenorrhea, galactorrhea, gynecomastia)
51
Lithium
- Use: bipolar (blocks relapse and acute manic events) - AE: tremor, hypothyroidism (GOITER), polyuria (NEPHROGENIC DI), teratogenesis - Narrow TI
52
What congenital birth defect does lithium cause?
- Ebstein anomaly
53
What drug is implicated in lithium toxicity in bipolar patients?
THIAZIDE USE
54
Buspirone
- MOA: stimulates 5-HT1A R - Use: GAD - Does not cause sedation, addiction, or tolerance - Takes 1-2 weeks to take affect - Does not interact with alcohol
55
Benefits to buspirone?
NO ABUSE POTENTIAL | NO SEXUAL DYSFUNCTION
56
SSRIs - Fluoxetine - Paroxetine - Sertraline - Citalopram
- MOA: 5-HT specific reuptake inhibitors - Use: depression, GAD, panic disorder, OCD, bulimia, social anxiety disorder, PTSD, premature ejaculation, premenstrual dysmorphic disorder - Takes 4-8 weeks to have an effect - AE: fewer than TCAs - GI distress, SIADH, SEXUAL DYSFUNCTION (anorgasmia, decreased libido)
57
SNRIs - Venlafaxine - Desvenlafaxine - Duloxetine - Levomilnacipran - Milnacipran
- MOA: Inhibit 5-HT and NE reuptake - Use: depression, GAD, diabetic neuropathy - AE: HTN most comon
58
Uses for venlafaxine?
Social anxiety disorder, panic disorder, PTSD, OCD
59
Serotonin Syndrome
- Can occur with any drug that increases 5HT (MAOi, SNRIs, TCAs) - Neuromuscular activity (clonus, hyperreflexia, hypertonia, tremor, seizure) - Autnomic stimulation (hyperthermia, diaphoresis, diarrhea) - Agitation
60
Treatment for serotonin syndrome?
CYPROHEPTADINE (5-HT2 R antagonist)
61
TCAs - Amitriptyline - Noritriptyline - Imipramine - Desipramine - Clomipramine - Doxepin - Amoxapine
- MOA: block reuptake of NE and 5HT - Use: major depression (persistent, recurring), peripheral neuropathy, chronic pain, migraine prophylaxis - AE: sedation, alpha1-blocking effects (postural hypotension, atropine-like AE - tachy, urinary retention, dry mouth), can prolong QT
62
Which TCA is used for OCD?
Clomipramine
63
TCA OD?
- Convulsions, coma, cardiotoxicity (arrythmia due to NA+ CHANNEL INHIBITION), respiratory depression, hyperpyrexia - Confusion and hallucinations in elderly - Rx: NaHCO3 (prevents arrhythmia)
64
Which TCA has least amount of AE?
Nortriptyline
65
MOAi - Tranylcypromine - Phenelzine - Isocarboxazid - Selegiline (selective MAO-B)
- MOA: MAO inhibition --> increase amine NT (NE, 5-HT, DA) - Use: atypical depression, anxiety - AE: HTN crisis (w/ tyramine), CNS stimulation
66
Which MAOi is selective for MAO-B?
Selegiline
67
What drugs are contraindicated with MAOi use?
SSRIs, TCAs, St. John's wort, meperidine, dextromethorphan - To prevent serotonin syndrome - Wait two weeks after stopping MAOi before starting 5-HT drugs or stopping dietary restrictions
68
Buproprion
- MOA: increase NE and DA - Use: depression, smoking cessation - AE: stimulant (tachy, insomnia), HA, seizure in ANOREXIA/BULIMIC - NO SEXUAL AE
69
What particular patient is Buproprion good for?
- Depression w/ increased sleep and decreased energy + smoker
70
What particular patient is Buproprion bad for?
Anorexic/bulimic
71
Mirtazapine
- MOA: alpha2-antagonist (increases release of NE and 5-HT), 5-HT2 and 3 R antagonist, H1 antagonist - Use: depression - AE: sedation (desirable if they have insomnia), increased appetite/weight gain (desirable in elderly/anorexic), dry mouth
72
Trazodone
- MOA: blocks 5-HT2, alpha1-adrenergic, and H1 R, weakly inhibits 5HT reuptake - Use: insomnia - AE: sedation, nausea, PRIAPISM, postural hypotension
73
Varenicline
- MOA: nicotinic ACh R partial agonist - Use: smoking cessation - AE: sleep disturbance