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Pharmacology > psych: pharmacokinetics, dosages, adverse reactions > Flashcards

psych: pharmacokinetics, dosages, adverse reactions Flashcards

1
Q

phenothiazine adverse reactions

A
  • CV: dizziness, fainting, ortho hypotension, tachycardia
  • DERM: photosensitivity
  • EENT: blurry vision, increased IOP, mydriasis, retinal pigmentation
  • ENDO: hyperglycemia, weight gain, impaired thermoregulation
  • GI: dry mouth, constipation, jaundice
  • GU: decreased libido, decreased ejaculation, urinary retention
  • NEURO: EPS, impaired memory
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2
Q

phenothiazines pharmacokinetics

A

page 271

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3
Q

phenothiazine dosages

A

page 271

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4
Q

atypical antipsychotic pharmacokinetics

A

page 273

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5
Q

atypical antipsychotic dosages

A

page 273

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6
Q

atypical antipsychotic adverse reactions

A
  • CV: Risperdal causes dose related hypotension and reflex tachycardia; clozapine causes ortho hypotension, tachycardia, and myocarditis; quetiapine causes palpitations and postural hypotension
  • GI: N/V
  • GU: sexual dysfunction (risperidone)
  • HEM: clozapine (agranulocytosis)
  • MISC: weight gain, hypersalivation (clozapine); risperidone may effect sleep
  • NEURO: headache, insomnia, dizziness, akinesia, somnolence, EPS, NMS
    *
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7
Q

MAOIs pharmacokinetics

A

page 277

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8
Q

MAOI dosages

A

page 277

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9
Q

MAOI adverse reactions

A
  • EENT: dilated pupils
  • GU: sexual dysfunction
  • NEURO: HYN crisis, serotonin syndrome
  • MISC: weight gain
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10
Q

TCA pharmicokinetics

A

page 278

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11
Q

TCA dosages

A

page 278

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12
Q

adverse reactions of TCAs

A

page 278

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13
Q

SSRI pharmacokinetics

A

page 280

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14
Q

SSRI dosages

A

page 280

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15
Q

SSRI adverse reactions

A
  • GI, nausea, diarrhea
  • GU: anorgasmia in men and women and ejaculatory disturbances in men
  • NEURO: agitation, headache, insomnia, nervousness, sedation, tremor, SEROTONIN SYNDROME
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16
Q

SNRIs pharmacokinetics

A

page 281

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17
Q

SNRI dosages

A

page 281

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18
Q

SNRI adverse reactions

A
  • CV: increase of 10-15 inDBP, diaphoresis
  • DERM: increased sweating, pruritus, rash
  • EENT: blurred vision, increased IOP
  • GI: nausea, dry mouth, constipation, anorexia, increased liver enzymes
  • GU: ejaculatory disturbances, erectile dysfunction, decreased libido, urinary hesitation
  • NEURO: tremor, seziures, fatigue, drowsiness, insomnia, headache
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19
Q

wellbutrin pharmacokinetics

20
Q

wellbutrin dosages

21
Q

clinical uses of wellbutrin asie from depression

A
  • smoking cessation (Zyban only)
  • off label treatment of adult ADHD
  • short term management of anxiety
  • increase sexual desire in women
22
Q

trazadone pharmacokinetics

23
Q

trazadone dosing

24
Q

trazadone adverse reactions

A
  • CV: ortho hypotension for 4-6 hours after dose
  • GI: mild n/v
  • GU: priapism
  • NEURO: drowsiness
25
Q

remeron pharmacokinetics

26
Q

remeron dosing

27
Q

remeron adverse reaction

A
  • GI: weight gain, dry mouth, increased appetite, n/v
  • MISC: flu-likesymptoms and abnormal dreams
  • NEURO: sedation
28
Q

lithium pharmacokinetics

29
Q

lithium dosing

30
Q

lithium adverse reactions

31
Q

dosing of depakote

32
Q

depakote adverse reactions

A
  • SERIOUS: severe hepatic and pancreatic toxicity and thrombocytopenia
  • LESSER: weight gain, transient alopecia, drowsiness, nausea, abdominal pain, agitation, dizziness, headache, rashes, irregular meses, and tremors
33
Q

uses of carbamazepine (Tegretol)

A

anticonvulsant

antimanic

antineuralgic

antipsychotic

34
Q

tegretol mechanism of action

A

decreases sodium and calcium ion influx into neuronal membranes, thus reducing their potnetiation ability

35
Q

abrupt withdrawal of tegretol may cause

A

status epilepticus

36
Q

labs that must be monitored with Tegretol

A

CBC (aplastic anemia)

LFTs

serum drug levels

37
Q

what is the last resort anxiolytic agent

38
Q

typical antipsychotics used to treat bipolaar mania

A

Zyprexa

Abilify

39
Q

agents used to treat anxiety disorders

A

benzodiazepines

40
Q

when are benzo’s particularly useful

A

acute situation anxiety and adjustment disorder where therapy is expected to be less than 6 weeks

41
Q

benzo mechanism of action

A

depress all levels of the CNS by enhancing the action GABA

enhanced GABA decreases neuronal excitation, thereby causing the anxiolytic effect

42
Q

clinical uses of benzos

A

anxiety

anticonculsant

muscle relaxer

adjuvant for anethsethia

treatment of alcohol addiction and withdrawal

43
Q

example of benzos

A

alprazolam (Xanax)

chlordiazepoxide (Librium)

clonazepam (Klonopin)

clorazepate (Tranxene ER)

diazepam (Valium)

lorazepam (Ativan)

oxazepam (Serax)

triazolam (Halcion)

44
Q

benzo adverse reactions

Pharmacology (28 decks)

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