endocrine disorders pharmacokinetics/adverse reactions/dosage Flashcards
cinacalcet adverse reactions
- CV: arrythmias, chest pain
- GI: vomiting, diarrhea
- MS: muscle aches/cramps, sudden tightening of muscles in hands, feet, face, throat
- NEURO: dizziness, weakness, burning, tingling, unusual feeling in lips, tongue, fingers, or feet, seizures
vasopressin adverse reactions
- CV: MI, diaphoresis
- DERM: rash, skin blanching, pallor
- GI: N/V, diarrhea
- NEURO: dizziness
- MISC: anaphylaxis, pain at injection site, water intoxication
desmopressin adverse effects
- CV: acute MI, thrombosis, facial flushing, edema, HTN, palpitations
- EENT: rhinorrhea/nasal congestion from nasal spray
- GI: abdominal cramps, nausea
- GU: decreased urination
- META: water intoxication, rapid weight loss
- NEURO: agitation, coma, headache, insomnia, confusion, seizures
Syntroid, Levoxyl, unithroid pharmacokinetics
page 200
Synthroid, Levoxyl, Unithyroid (T4)
adverse reactions
- CV: tachycardia
- DERM: urticaria
- META: heat intolerance
- NEURO: tremors, rash
liothyronine
(Cytomel, Triostat)
pharmacokinetics
page 201
T4 dosage
50mcg initially
may be increased every 2-3 weeks
liothyronin dosage
5mcg/day
may increase by 5-10mcg/week
liothyronine maintenance dose for myxedema goiter
75 mcg daily
liothyronine adverse reactions
- CV: arrythmias, tachycardia
- DERM:reversible hair loss in children at begining, dry skin, rash, hives
- GI: intolerance
- NEURO: headaches
dosage of liotrix
50/12.5 mcg then double every month until desired results are achieved
liotrix adverse reactions
- CV: CARDIOVASCULAR COLLAPSE, arrythmia, tachycardia, HTN
- DERM: increased sweating
- ENDO: hyperthyroidism, menstrual irregularities
- GI: N/V, cramps
- META: weight loss, heat intolerance
- MISC: accelerates bone maturation in children
- NEURO: insomnia, irritability, nervousness, headache
PTU pharmacokinetics
page 204
PTU dosage guidelines
page 204
PTU adverse reactions
- DERM: hair loss, pruritis, rash, skin pigmentation, urticaria
- GI: nausea
- HEM: agranulocytosis can occur as long as 4 months after therapy and can cause fatal hepatitis
- MISC: lupus-like syndrome
- NEURO: headache, paresthesia
methimazole pharmacokinetics
page 205
dosing of methimazole
start with 15-60mg as single or divided doses for 6-8 weeks
cinacalcet pharmacokinetics
page 207
calcitrol pharmicokinetics
page 208
calcijex dosage/administration
injection 0.5-4mcg every other day
rocaltrol dosage/administration
PO: 0.25-1mcg/day
calcitrol adverse reactions
- CV: arrythmias
- GI: constipation, metallic taste, nausea
- META: hypercalcemia, polyuria
- NEURO: headach, irriability
vasopressin pharmacokinetics
page 209
vasopressin dosage guidelines
page 209
oxytocin pharmacokinetics
page 210
oxytocin adverse reactions
- CV: tachycardia, premature ventricular contractions, hypotension (mom and baby)
- EENT: neonetal retinal hemorrhage
- GI: N/V in both
- MISC: prolonged IV infusion has caused severe water intoxication with seizures, coma, and death
- OB/GYN: postpartum hemorrhage in mother
desmopressin pharmacokinetics
page 210
desmopressin (DDAVP, stimate) dosage information
page 210
lypressin pharmacokinetics
page 211
lypressin dosing
nasal spray, 1-2 sprays per nostril QID
(adults and children over 12)
lypressin adverse reactions
- CV: chest tightness, SOB, dyspnea
- EENT: eye pain/irritation, itching, irritation or sores inside nose, runny/stuffy nose
- GI: abdominal/stomach cramps, increased BM, heartburn
- NEURO: coma, confusion, convulsions, drowsiness, headache, weight gain, problems with urination
Actual practice dosage of lypressin
ranges from 1 spray at bedtime to 10 sprays every 3-4 hours
adverse reactions of somatrem and recombinant somatropin
- CV: edema of hands anf feet
- ENDO: hypoglycemia, hypothyroidism, insulin resistance
- MISC: pain at injection site
pharmacokinetics of octreotide (Sandostatin)
page214
dosage of octreotide (Sandostatin)
page 214
octreotide (Sandostatin)
adverse reactions
- CV: sinus bradycardia, arrhythmias
- ENDO: hypothyroidism
- GI: gallbladder abnormalities (stones and biliary sludge), diarrhea, N/V, abdominal discomfort, gas, distention, constipation
- META: hypoglycemia or hyperglycemia can develop in acromegaly patients
glucocorticoid pharmacokinetics
page 215
glucocorticoid mechanism of action:
glucose metabolism, inflammation/immune function, other effects
page 215
glucocorticoids adverse reactions
- CV: tachycardia
- DERM: acne, delayed wound healing, facial flushing
- ENDO: hyperglycemia, cushings syndrome
- GI: abdominal distention, diarrhea, constipation, heartburn, increased appetite, peptic ulcers, GI bleeds
- MISC: increased susceptibility to infections, allergic reactions
- NEURO: anxiety, insomnia, mood swings, hallucinations, depression
fludrocortisone (Florinef) pharmacokinetics
page 217
fludrocortisone (Florinef dosage
page 217
fludrocortisone adverse reactions
- DERM: acne
- GI: ulcers, increased appetitie, abdominal distention, upset stomach, vomiting
- META: cold, unusual hair growth
- MISC: potential for decreases in inflammatory and immune responses, weight gain, swollen limbs
- NEURO: dizziness, headaches, exaggerated sense of well-being, insomnia, mood swings, depression, anxiety
aminoglutamide (Cytadren)
pharmacokinetics
page 218
aminoglutamide (Cytadren) dosage
page 218
aminoglutethimide (Cytadren)
adverse reactions
- GI: nausea, anorexia (first few weeks)
- NEURO: drowsiness, dizziness, headache, weakness
anastrozole (Arimedex)
pharmacokinetics
page 219
anastrozole (Arimedex) dosage
page 219
anastrozole (Arimedex)
adverse reactions
- CV: peripheral edema
- GI: N/V
- GYN: vaginal bleeding, hot flashes
- MISC: flu syndrome, cataracts
- MS: fracture, sore muscles, fatigue, accidental injuries
- NEURO: mood disturbances
