Diabetes: pharmacokinetics, dosages, adverse reactions Flashcards
1
Q
considerations for oral therapy in patients with T2DM
A
page 225
2
Q
ADA algorithm for treatment
A
page 226
3
Q
sulfonylureas pharmacokinetics
A
page 227
4
Q
sulfonylurease dosages
A
page 228
5
Q
sulfonylureas adverse reactions
A
- CV: edema, syncope
- DERM: rash, urticaria, pruritis, photsensitivity
- EENT: blurry vision
- ENDO: hypoglycemia, hyponatremia
- GI: anorexia, N/V, diarrhea, gas, heartburn, constipation
- HEM: aplastic anemia, hemolytic anemia, bone marrow depression, thrombocytopenia, agranulocytosis
- MISC: disulfiram-like reaction especially if patient drinks alcohol
- MS: arthralgia, leg cramps, myalgia, tremors
- NEURO: anxiety, depression, dizziness, headache, insomnia
- RENAL: minor diuretic effect
6
Q
metformin pharmacokinetics
A
page 229
7
Q
dosing of metformin and metformin combinations
A
page 229
8
Q
metformin adverse reactions
A
- GI: abdominal pain, nausea, diarrhea, bloating, metallic taste
- META: hypoglycemia, lactic acidosis (rare)
- higher risk of lactic acidosis with renal dysfunction, increased age, DM, HF, other conditions having risks for hypoperfucion and hypoxemia
- MISC: decreased B12 levels
9
Q
meglitinide dosages
A
page 230
10
Q
meglitidine pharmacokinetics
A
page 230
11
Q
meglitinide adverse reactions
A
page 230
12
Q
TZD pharmacokinetics
A
page 231
13
Q
TZD dosages
A
page 231
14
Q
TZD adverse reactions
A
page 232
15
Q
alpha-glucosidase inhibitor pharmacokinetics
A
page 232
