Diabetes: pharmacokinetics, dosages, adverse reactions Flashcards
considerations for oral therapy in patients with T2DM
page 225
ADA algorithm for treatment
page 226
sulfonylureas pharmacokinetics
page 227
sulfonylurease dosages
page 228
sulfonylureas adverse reactions
- CV: edema, syncope
- DERM: rash, urticaria, pruritis, photsensitivity
- EENT: blurry vision
- ENDO: hypoglycemia, hyponatremia
- GI: anorexia, N/V, diarrhea, gas, heartburn, constipation
- HEM: aplastic anemia, hemolytic anemia, bone marrow depression, thrombocytopenia, agranulocytosis
- MISC: disulfiram-like reaction especially if patient drinks alcohol
- MS: arthralgia, leg cramps, myalgia, tremors
- NEURO: anxiety, depression, dizziness, headache, insomnia
- RENAL: minor diuretic effect
metformin pharmacokinetics
page 229
dosing of metformin and metformin combinations
page 229
metformin adverse reactions
- GI: abdominal pain, nausea, diarrhea, bloating, metallic taste
- META: hypoglycemia, lactic acidosis (rare)
- higher risk of lactic acidosis with renal dysfunction, increased age, DM, HF, other conditions having risks for hypoperfucion and hypoxemia
- MISC: decreased B12 levels
meglitinide dosages
page 230
meglitidine pharmacokinetics
page 230
meglitinide adverse reactions
page 230
TZD pharmacokinetics
page 231
TZD dosages
page 231
TZD adverse reactions
page 232
alpha-glucosidase inhibitor pharmacokinetics
page 232
alpha-glucosidase inhibitor dosage
page 232
alpha-glucosidase inhibitor adverse reactions
page 233
amylin analogue pharmacokinetics
page 233
amylin analogue dosage
page 233
amylin analogue adverse reactions
page 234
GLP-1 agonists pharmacokinetics
page 234
GLP-1 agonists dosage
page 234
GLP-1 agonists adverse reactions
page 234
DDP-IV pharmacokinetics
page 235
DDP-IV dosage
page 235
DDP-IV adverse reactions
page 235
glucagon pharmacokinetics
page 236
glucagon dosage
page 236
glucagon adverse reactions
page 236
insulin pharmacokinetics
pag 238
onset/peak/duration of insulins
page 238
