Psych high yield Flashcards
type of drug -
sertraline
SSRI
type of drug -
FLUOXETINE
SSRI
type of drug -
PAROXETINE
SSRI
type of drug -
CITALOPRAM
SSRI
type of drug -
ESCITALOPRAM
SSRI
type of drug -
AMITRIPTYLINE
TCA
type of drug -
LOFEPRAMINE
TCA
type of drug -
CLOMIPRAMINE
TCA
type of drug -
DOSULEPIN
TCA
type of drug -
VENLAFAXINE
SNRI
type of drug -
DULOXETINE
SNRI
type of drug -
MIRTAZAPINE
NASSA
noradrenaline serotonin specific antidepressant
type of drug -
MOCLEBEMIDE
MAOI
monoamine oxidase inhibitors
type of drug -
PHENELZINE
MAOI
type of drug -
TRAZADONE
SARI
SSRI MOA
block serotonin reuptake from synaptic cleft
overall reduction in inhibitory controls of serotonin release
SSRI main S/E
GI upset - abdominal pain, constipation, nausea
TCA MOA
- block reuptake of noradrenaline
- block reuptake of serotonin
^ via blocking their transporter
which molecules are antagonised by TCAs?
- histamine
- dopamine
- acetylcholine
main TCA S/Es
- sedative
- weight gain
- anticholinergic syndrome - dry mouth + constipation
MOA of SNRI
selectively block noradrenaline and serotonin (TCA are not selective)
main SNRI S/Es
GI upset
hypertension
palpitations
MOA for mirtazapine
presynaptic antagonism of:
- noradrenaline
- serotonin
- histamine
which drug blocks alpha2-adrenergic receptors, causing increase in neurotransmitter release?
mirtazapine
which drug can be used to counter S/E of SSRI?
mirtazapine
MOA of MAOI
- block monoamine oxidase
- prevents breakdown of serotonin + noradrenaline
reversible MAOI?
moclebemide
Irreversible MAOI
phenelzine
sodium valproate MOA
blocks voltage sensitive Na channels
increase in GABA level
lamotrigine MOA
blocks voltage sensitive Na channels
mood stabiliser causing SJS
lamotrigine
MOA for typical anti-psychotics
block dopamine
D2 receptors
extra-pyramidal side effects caused by?
typical anti-psychotics
examples of extra-pyramidal S/Es
acute dystonia
akathisia
Parkinsonism
tardive dyskinesia
muscle rigidity, feber, autonomic instability + cognitive changes - in responsive to antipsychotics (usually 1st gen)
neuroleptic malignant syndrome
how can extra-pyramidal S/Es be managed
procyclidine
rapid tranquillisation
1st - oral lorazepam
2nd - IM ^
MOA of benzodiazepines
activate GABAa receptors
causes inhibition of neurotransmission
hence sedative relaxing affect
Patient fake illness for attention, includes adding blood to urine sample etc
admitting patient makes them happy
Munchausens / factitious disorder
presentation of non-euro symptoms without an obvious cause. Admission does not make them any happier
somatoform disorder
presence of neurological symptoms without any cause - usually stressed pt
conversion disorder
patient believes they have a serious condition and requests frequent investigations
+ high health anxiety
hypochondriasis
patient shows no concern over worrying symptoms such as not being able to move a limb
La Belle indifference
PTSD symptoms<1 month
acute stress reaction
Delusion that someone is in love with them
De Clerambault’s syndrome
delusion where you believe partner is unfaithful for no reason
Othello syndrome
fixed false belief that you are dying/degrading
Cotard’s syndrome
the belief that different people are the same person, but in disguise
fregoli
belief that close relative/partner has been replaced by an imposter
capgras delusion
thought disorder -
no connection between ideas in succession
knights move thinking
thought disorder -
many ideas rapidly in succession - maintains link
flight of ideas
SSRI contraindication in elderly
anti-coagulant such as warfarin
section 5(2)
emergency detention
section 2
short term detention / assessment
section 3
long term detention up to 6 months
1st line tx for adolescent bullimia nervosa
Bullimia nervosa family therapy / FT-BN
tx for acute alcohol withdrawal?
lorazepam / benzos
tx for mild alcohol dependence
CBT
management for high/at risk alcohol dependence?
CBT + nalmefene
- fever
- muscle rigidity
- confusion
- rhabdo
after dopamine antagonist?
neuroleptic malignant syndrome
slow, withdrawn speech, negative symptom of schizophrenia
alogia
S/Es of valproate?
alopecia
weight gain
tremor
cardiac complication of anorexia
mitral valve prolapse from loss of cardiac muscle
1st line for severe alzheimers
memantine / NMDA antagonist
donepezil contraindication
asthma
- acute confusion
- hallucinations
- autonomic hyperactivity
72hrs after alcohol
delirium tremens
first line tx for delirium tremens
lorazepam
- diarrhoea
- mydriasis (dilated pupils)
- yawning
- runny nose
- goose bumps
opiate withdrawal
Name that OD:
- constipaiton
- urine retention
- delirium
- dilated pupils
- dry skin
amytriptyline
Drug syndrome:
- agitated
- hyperthermic
- sweating
- headache
serotonin syndrome:
SSRI + cocaine/ methamphetamines
Name that OD:
- agitation
- tachy
- sweats
- hypertension
- chest pain
cocaine
tremers
sweating
agitation
6-12 hours after alcohol
alcohol withdrawal
antipsychotics associated with hyperprolactinaemia?
- amisulpride
- risperidone
treatment for extrapyramidal S/Es of dopamine agonists (ie acute dystonia)
procyclidine
IV Benzes
screening for post natal depression
Edinburgh scale
parksons + cog impairment vs LBD?
parkinsons: motor symptoms present for 1 year> cog/ memory issues