Psych Drugs Flashcards
FGA MOA
block D2 receptors (increases cAMP)
list the FGA
- haloperidol
- pimozide
- trifluoperazine
- fluphenazine
- thioridazine
- chlorpromazine
high potency FGA
haloperidol, trifluoperazine, fluphenazine
low potency FGA
chlorpromazine, thioridazine
compare high potency vs low potency side effects
high potency: more neurologic AE (extrapyramidal sx)
low potency: more anticholinergic, antihistamine, a1-blockade
adverse effects FGA
1) lipid soluble –> stored in body fat –> slow to be removed from body
2) hyperprolactinemia, galactorrhea
3) dyslipidemia, weight gain
4) antimuscarinic
5) antihistamine (sedation)
6) alpha-1 blockade (orthostatic hypotension)
7) QT prolongation
8) Neuroleptic malignant syndrome
9) EPS
what are some specific side effects of chlorpromazine and thioridazine
Chlorpromazine: corneal deposits
thioridazine: retinal deposits
MOA atypical antipsychotics
5-HT and D2 antagonists
list the SGA
- aripiprazole
- asenapine
- clozapine
- olanzapine
- quitiapine
- iloperidone
- paliperidone
- risperidone
- lurasidone
- ziprasidone
clozapine AE
agranulocytosis and seizures (WATCH BONE MARROW AND WBC CLOSELY)
risperidone AE
hyperprolactinemia
buspirone MOA
stimulates 5-HT receptors
clinical uses for TCAs
- major depressive disorder
- peripheral neuropathy
- chronic neuropathic pain
- migraine prophylaxis
- OCD (clomipramine)
- nocturnal enuresis (imipramine)
bupropion MOA
inhibits NE and dopamine reuptake
also used for smoking cessation
mirtazapine MOA
a2-antagonist (increases release of NE and 5-HT)
5-HT2 and 3 receptor antagonist
H1 antagonist
