Psych Flashcards

1
Q

Mx of PTSD?

A

Watchful waiting

Trauma-CBT / EMDR

If not tolerated SSRI / Venlaflaxine / Risperidone (v severe)

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2
Q

How long to continue antidepressants for after resolution of sx?

A

6 months

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3
Q

Which atypical antiphsychotic has highest risk of dyslipidaemia + obesity?

A

Olanzapine

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4
Q

SSRI of choice post MI?

A

Sertraline

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5
Q

presence of a delusion that a famous is in love with them, with the absence of other psychotic symptoms

Name?

A

Erotomania (De Clerambault’s syndrome)

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6
Q

What is histrionic personality disorder characterised by?

A

inappropriate sexual seductiveness, suggestibility and intense relationships

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7
Q

What is othellos syndrome?

A

pathological jealousy where a person is convinced their partner is cheating on them without any real proof

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8
Q

Adverse effects of atypical antipsychotics?

A

weight gain
clozapine is associated with agranulocytosis (see below)
hyperprolactinaemia

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9
Q

Duloxetine MoA?

A

Serotonin-NA reuptake inhibitor

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10
Q

When do you get:
Symptoms
Seizures
DT

with alcohol withdrawal?

A

symptoms: 6-12 hours
seizures: 36 hours
delirium tremens: 72 hours

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11
Q

Mx of DT?

A

Chlordiazepoxide, lorazepam or diazepam are used in the treatment of delirium tremens/alcohol withdrawal

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12
Q

Which receptor do typical antipsychotics and atypicals act on?

A

Typical - D2 antagonist - blocking dopaminergic transmission in mesolimbic pathways

Atypical - D2, D3, D4 5HT

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13
Q

When can antidepressants be stopped after remission?

A

6 months after - reduce risk of relapse

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14
Q

Risk of developing schizophrenia
monozygotic twin has schizophrenia =
parent has schizophrenia =
sibling has schizophrenia =
no relatives with schizophrenia =

A

monozygotic twin has schizophrenia = 50%
parent has schizophrenia = 10-15%
sibling has schizophrenia = 10%
no relatives with schizophrenia = 1%

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15
Q

Which drugs can cause urinary retention particularly in those with BPH?

A

TCAs eg amitriptylline

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16
Q

What receptors does Olanzapine act on?

A

Mainlt - 5HT2A (serotonin) antagonism + D2 (dopamine) antagonism

17
Q

What are the main features of PTSD?

A

re-experiencing e.g. flashbacks, nightmares

avoidance e.g. avoiding people or situations

hyperarousal e.g.hypervigilance, sleep problems

18
Q

Examples of GABA drugs?

A

benzodiazipines increase the frequency of chloride channels

barbiturates increase the duration of chloride channel opening

19
Q

How to withdraw from benzos?

A

switch patients to the equivalent dose of diazepam

reduce dose of diazepam every 2-3 weeks in steps of 2 or 2.5 mg

time needed for withdrawal can vary from 4 weeks to a year or more

20
Q

Bulimia pharmacological mx?

A

High dose fluoxetine but limited evidence base

21
Q

Adverse effects of non-selective monoamine oxidase inhibitors

A

hypertensive reactions with tyramine containing foods e.g. cheese, pickled herring, Bovril, Oxo, Marmite, broad beans

anticholinergic effects

22
Q

Can you get alopaecia with long term lithium?

23
Q

Dosulepin MoA? anything to be aware of?

A

TCA

Dangerous in overdose

24
Q

Duloxetine MoA?

A

serotonin and noradrenaline reuptake inhibitor

25
Which SSRI has highest risk of discontinuation sx?
Paroxetine
26
What type of memory loss is seen in dementia v pseudodementia?
Dementia = shorter term memory + recent events
27
Which TCA is safest in overdose
Lofepramine
28
ECT side effects?
Short-term side-effects >headache >nausea >short term memory impairment memory loss of events prior to ECT >cardiac arrhythmia Long-term side-effects >some patients report impaired memory
29
Features of post concussion syndrome?
headache fatigue anxiety/depression dizziness
30
Anorexia bloods?
most things low G's and C's raised: growth hormone, glucose, salivary glands, cortisol, cholesterol, carotinaemia
31
What is associated with increase in mortalitiy in dementia patients?
antipsychotics
32
Which APOE allele is highest risk of alzheimers?
y4 allele
33
Lewy body dementia scan?
SPECT