PSY1022 WEEK 10 COG 2 Flashcards
LONG-TERM POTENTIATION (LTP)
Gradual strengthening of the connections among neurons from repetitive stimulation.
- hippocampus, amygdala and other structures
- unsure if directly responsible for memory storage.
ENGRAM
The physical trace of each memory in the brain.
- Karl Lashley.
Doesn’t exist, at least like that.
ASSEMBLIES
Idea that engram is instead located in assemblies of neurons in the brain.
- Donald Hebb
Mostly right. Neurons that “fire together wire together”
LTP AND GLUTAMATE
LTP tends to occur at synapses where the sending neuron releases the neurotransmitter glutamate into the synaptic cleft.
- glutamate activates postsynaptic receptors for NMDA and AMPA
- results in enhanced learning
RETROGRADE AMNESIA
Loss of memories from our past.
ANTEROGRADE AMNESIA
Inability to encode new memories from our experiences.
- more common than retrograde.
GENERALISED AMNESIA
Loss of all memories of previous life. Very rare.
DAMAGE TO HIPPOCAMPUS
Impairs explicit memory, but leaves implicit memory intact.
- factual component of memories.
DAMAGE TO AMYGDALA
Can remember facts about fear-producing experience, but not the fear.
- emotional component of memories.
EMOTIONAL MEMORY
Hormones adrenaline and norepinephrine are release with stress.
Stimulates protein (beta-adrenergic) receptors on nerve cells, which solidify emotional memories.
Propranolol blocks this effect of adrenaline. Can be used to dampen effects of traumatic memories.
DEMENTIA
Serious loss of global cognitive ability in a previously unimpaired person.
- most frequent cause is Alzheimer’s (40-60%)
ALZHEIMER’S DISEASE
The most frequent cause of dementia. (40-60%)
Risk is 13% for those over 65.
42% for those over 85.
Language and memory are effected.
Memory loss begins with recent events, with distant events the last to go.
Loss of synapses and death of cells in the hippocampus and cerebral cortex.
Physical activity seems to reduce incidence, as does education and intellectual activity.
META-MEMORY
Knowledge about our own memory abilities and limitations. Develops during childhood.
INFANTILE AMNESIA
Inability of adults to remember personal experiences that took place before and early age.
2-3 years old.
- could be because hippocamus is underdeveloped in infants.
- also no sense of self.
FLASHBULB MEMORY
Emotional memory that is extraordinarily vivid and detailed.
- Sept 11, JFK assassination, etc.
But not always accurate. Neisser and Harsch.
- then called phantom flashbulb memories.