Psoriasis Flashcards
Psoriasis
Chronic autoimmune inflammatory skin condition
Psoriasis involves a ___ mediated abnormal immune response
T-cell
Pathology of psoriasis
Keratinocyte hyperproliferation (loss of control of epidermal turnover)
Disorders associated with psoriasis
Psoriatic arthritis IBD Uveitis Coeliac disease Metabolic syndrome
Presentation of chronic plaque psoriasis
Red, scaly, itchy, well demarcated plaques on extensor surfaces, scalp, sacrum, hands, feet, trunk Symmetrical lesions Auspitz sign Kobner phenomenon = Nail changes
Auspitz sign (psoriasis)
Bleeding on scale removal
Kobner phenomenon (psoriasis)
New plaques at a site of skin trauma
Increased ____ risk in patients with severe psoriasis
Cardiovascular
Topical therapies for psoriasis
Emollients
Vitamin D analogues: (calcipotriol, calcitriol)
Steroids: (risk of rebound with potent steroids)
Betnovate
Coal tar
Dithranol
Keratolytics: (salicylic acid)
Systemic therapies for psoriasis
Phototherapy
Retinoids
Immunosuppression: (methotrexate)
Biological agents
Typical regime for psoriasis treatment
1stline:Vit. D analogues +/- topical steroids + tar or salicylic acid ± UVB
2ndline:Retinoids, PUVA, UVB, immunosuppressants
3rdline:Dithranol
Presentation of guttate psoriasis
Young patients
Small spots of psoriasis
After strep throat
Presentation of erythrodermic psoriasis
Widespread, intense inflammation of the skin
Peeling rash all over the body, itches and burns intensely
Presentation of palmoplanar pustular psoriasis
Yellow/brown pustules on the hands and the soles of the feet
What type of psoriasis requires emergency treatment
Erythrodermic psoriasis
