Psoriasis Flashcards

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1
Q

causes of psoriasis

A
  • genetics (Th1 and Th17 stimulation keratinocyte proliferation, AMP release and neutrophil-attracting chemokines)
  • environmental factors e.g. stress, drugs, infection
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2
Q

presentation of psoriasis

A
  • plaques
  • symmetrical
  • extensor sites e.g. scalp, sacrum
  • nail changes
  • systemic diseases
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3
Q

hallmark of psorasis

A

chronic, demarcated, bilateral scaly, erythematous plaques

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4
Q

nail changes that can occur in psoriasis

A

onycholysis: lifting from the nail-bed
nail pitting
dystrophy
subungual hyperkeratosis

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5
Q

describe Koebner’s phenomenon

A

development of psoriasis in areas of previous trauma

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6
Q

systemic diseases that can occur alongside psoriasis

A

arthritis
metabolic syndromes
Crohn’s
cancer

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7
Q

diagnosis

A

auspitz sign- removal of surface scale reveals tiny bleeding points

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8
Q

types of psoriasis

A
  • vulgaris
  • guttate (everywhere)
  • palmoplantar pustular
  • erythrodermic
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9
Q

management of psoriasis

A
  • vitamin D analogues
  • coal tar (use everywhere)
  • dithranol
  • steroid ointment (combination)
  • emollients
  • phototherapy
  • systemic treatments e.g. methotrexate
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10
Q

examples of vitamin D analogues

A

calcipotriol (localised plaques)

calcitriol (flexures)

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11
Q

when is dithranol used?

A

few localised plaques, short contact

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