Biochemistry Flashcards
1
Q
scale for photosensitivity of skin
A
Fitzpatrick skin scale
2
Q
main groups of prophyria’s
A
- phototoxic
- blistering and fragility
- acute attack
- severe congenital porphyria
3
Q
example of phototoxic porphyria
A
erythropoietic protoporphyria
4
Q
example of severe congenital porphyria
A
congenital erythropoietic porphyria
5
Q
two common porphyria’s
A
- porphyria cutanea tarda type 1
2. erythropoietic protoporphyria
6
Q
PCT type 1 enzyme
A
deficiency in uroporphyrinogen decarboxylase
7
Q
cause of PCT type 1
A
chronic liver disease or excess iron in the liver
8
Q
presentation of PCT type 1
A
blisters, hyperpigmentation, hypertrichosis, solar urticaria and morphoea
9
Q
Erythropoietic protoporphyria enzyme
A
ferrochelatase
10
Q
Erythropoietic protoporphyria diagnosis and management
A
Investigations are RBC, fluorocytes, USS of biliary tract. Management is 6-month LFTs, RBC porphyrins and photoprotection measures.
