Immunology Flashcards
three immunological functions of keratinocytes
- sense cell surface receptors of pathogens
- produce AMPs that directly kill pathogens
- produce cytokines and chemokine
describe Langerhans cells
APCs with Birbeck granules that present to T cells
which T cells are found in the epidermis?
CD8+ T cells (signal to Tc cells)
which T cells are found in the dermis
CD4+ T cells (Th1 and Th2)
CD8+ T cells
dendritic cells in the dermis
dermal DC: APCs and secrete cyto/chemokines
plasmacytoid DC: produce TFN-alpha
types of immune cells in the dermis
- T cells
- dendritic cells
- macrophages
- neutrophils
- mast cells
define hypersensitivity
immune response that causes collateral damage to self
define allergy
person’s immune system reacts to a normally harmless substance in the environment
Type 1 reaction examples
urticaria
angioedema
anaphylaxis
investigations for a type 1 reaction
history IgE bloods skin prick challenge test serum mast cell tryptase (anaphylaxis)
management of type 1 reactions
allergen avoidance antihistamines corticosteroids adrenaline sodium cromoglycate immunotherapy medic alert bracelet
define type 3 reaction
arthus reaction
example of a type 4 reaction
allergic contact dermatitis
management of type 4 reaction
avoidance emollients topical steroids phototherapy immunosuppressants
