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Dermatology > Psoriasis > Flashcards

Psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

What is the pathophysiology of psoriasis?

A

Abnormal T cell activity stimulates keratinocyte proliferation.

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2
Q

What nail signs do you see with psoriasis?

A

Pitting

Oncholysis

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3
Q

What is the treatment for guttate psoriasis?

A

Reassure and given topical treatment if symptomatic

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4
Q

Describe the management of psoriasis

A
  1. Regular emolliants
  2. Potent corticosteroid + vitamin D analogue applied once daily (applied seprately) for up to 4 weeks
  3. If no improvement then vitamin D analogue twice daily
  4. If no improvement after 8 - 12 weeks then a potent steroid twice daily or coal tar preparation
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5
Q

What is calcipotriol?

A

Vitamin D analogue that works by reducing cell division and differentiation

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6
Q

Aside from topical treatments what else is used to treat psoriasis?

A 
Narrow band UV B (given 3 x per week)
PUVA 
Oral methotrexate (particularly if there is also joint disease)
Ciclosporin 
Retinoids 
Infliximab
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7
Q

How does coal tar work?

A

Inhibits DNA synthesis

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8
Q

How does dithranol work and how do you use it?

A

Inhibits DNA synthesis. You have to wash it off after 30 mins. Causes burning and staining

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9
Q

When are the peak ages that people get psoriasis?

A

2nd and 5th decades

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10
Q

What are the 5 main patterns of psoriatic arthritis?

A 
Oligoarthritis
Symmetrial polyarthritis 
Distal phalangeal joint disease
Destrcuctive arthritis 
Axial arthritis
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11
Q

Describe the treatment pwatway of psoriasis?

A
  1. Topical treatment
    - Emolliants
    - Tar
    - Vitamin D analogues
    - Salicylic acid
    - Dithranol
    - Tpical steroids
  2. Phototherapy
  3. Oral treatment
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12
Q

How does coal tar work?

A

Reduces DNA synthesis and epidermal proliferation

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13
Q

What systemic therapies are used in psoriasis?

A

Methotrexate

Ciclosporin

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14
Q

What do you need to monitor whilst on methotrexate?

A

FBC
U & E
LFTs
Also need to take folic acid

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15
Q

What do you need to monitor whilst on ciclosporin?

A

FBC
U & E
LFTs
Cholesterol GFR

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16
Q

What do you need to monitor whilst on retinoids?

A 
FBC
U & E 
LFTs
Cholesterol 
Triglycerides
17
Q

Which topical treatment for psoriasis should be avoided in people with disorders of calcium metabolism?

A

Calcipotriol

Dermatology (16 decks)

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