Bullous disorders

Question 1

What is bullous pemphigus?

Answer 1

An autoimmune blistering diorder of the epidermis which is seen in middle age. It causes localised flaccid bullae of the skina nd mucous membranes

Question 2

What causes bullous pemphigus?

Answer 2

IgG antibodies directed against desmosome components resulting is loss of adhesion between the cells and splitting within the epidermis

Question 3

What disease shows an intra - epidermal split with a typical chicken wire pattern on immunofluoresence?

Answer 3

Bullous pemphigus. Immunoflurecense due to intercellular IgG

Question 4

What is bullous pemphigoid?

Answer 4

An autoimmune disorder where the target molecules are found in the lamina lucida and this causes the development of sub epidermal blisters

Question 5

What disease revelas a sub epidermal split and a linear band of IgG along the basement membrane on immunofluoresence?

Answer 5

Bullous pemphigoid

Question 6

What are the antibodies towards in pemphigus vulgaris?

Answer 6

Desmoglein 3 - a cadherin type epithelial cell adhesion molecule

Question 7

Which part of the skin in affected in pemphigus?

Answer 7

Intra epidermal

Question 8

Which part of the skin is affected in dermatitis herpatiformis?

Answer 8

Sub epidermal