Psoriasis

Question 1

Pathology of psoriasis

Answer 1

hyperproliferation of the keratinocytes
in the epidermis, with an increase in the
epidermal cell turnover rate.
shortening cell cycle results in 28-fold
production of keratinocytes (4-5 days instead
of 37-40 days).

Question 2

Age of psoriasis

Answer 2

Ø Type I – youth
Ø Type II - adult

Question 3

Immune basis of pathology of psoriasis

Answer 3

T cell mediated
Th1, 17, 22

Question 4

What infections can trigger psoriasis

Answer 4

Post streptococcus and HIV

Question 5

Drugs that trigger psoriasis

Answer 5

BASL
BETA BLOCKERS
ANTI malarials
Sudden Steroids withdrawal
Lithium

Question 6

Psoriasis manifests on. The…..

Answer 6

• Extensor surface of the elbows and knees
• scalp
• lumbosacral areas
• intergluteal clefts
• glans penis

Question 7

1st line treatment in psoriasis

Answer 7

Emollients

Question 8

Treatment of psoriasis

Answer 8

1st line: emollient
2nd line :topical agents (steroids)
3rd line: phototherapy
4th line: systemic agents
5th line: biologic agents

Question 9

What is the drug contraindicated in psoriasis

Answer 9

Oral systemic corticosteroids

Question 10

2nd line treatment in psoriasis

Answer 10

Topical corticosteroid or vit D